Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 127 for “"nanomedicine"”.
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Development of an inhalable nanomedicine for lung cancer
Lung cancer affects over 2 million people worldwide and became the major cause of death in cancer patients (18.4%) in 2018. The treatment of non-small cell lung cancer (NSCLC), accounting for 85% of total lung cancer, involves chemotherapy, radiotherapy, and surgery. However, such a therapeutic …
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Sviluppo di nanomedicine per la somministrazione oculare di farmaci
… maggiori. I recenti progressi nel campo delle nanomedicine hanno contribuito a migliorare la somministrazione di farmaci nel segmento oculare posteriore. I nanosistemi hanno fornito molteplici vantaggi, tra cui la capacità di migliorare la somministrazione di farmaci scarsamente solubili e di …
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Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass, which acts as a barrier that impedes the delivery of antitumor drugs into the tumor microenvironment and reduces the therapeutic efficacy. The objective of …
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Fighting cancer with nanomedicine−drug-polyester nanoconjugates for targeted cancer therapy
The aim of my Ph. D. research is to develop drug-polyester nanoconjugates (NCs) as a novel translational polymeric drug delivery system that can successfully evade non-specific uptake by reticuloendothelial system (RES) and facilitate targeted cancer diagnosis and therapy. By uniquely integrating …
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Optimizing Emerging Healthcare Innovations in 3D Printing, Nanomedicine, and Imageable Biomaterials
… efforts in these fields. First, in the realm of nanomedicine, we discuss the optimization and characterization of sodium thiosulfate facilitated gold nanoparticle synthesis. While many nanoparticles have been examined as agents for photothermal cancer therapy, we closely examine the structure and …
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Design, Development and Evaluation of Dual Drug Nanomedicine for Non-Small Cell Lung Cancer
<p>Resistance to conventional chemotherapy is a big challenge in the treatment of cancer including non-small cell lung cancer (NSCLC). A combination of natural chemo sensitizer agents with chemotherapy offers unique advantages over monotherapy alone. However, free unbound drugs, (in combination or …
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The impact of hypoxia on nanomedicine uptake and efflux in human breast cancer cells
… to undermine the therapeutic efficacy of nanomedicines designed for endocytic uptake and specific intracellular trafficking (Chapter 1). The aim of this thesis was to examine the impact of hypoxia and simulated reperfusion on the in vitro uptake and release of nanomedicines by human breast …
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Tackling the Bottlenecks in Translational Nanomedicine: Towards Precision in Size Control and Facile Nanoformulation
Nanomedicine has been an intensive research area for decades. Despite the immense research output, the translation of nanoparticle-based formulations into clinics has been limited. The efficient clinical translation of nanomedicine is impeded by several bottlenecks that include low targeting …
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RNA Interference for Improving the Outcome of Islet Transplantation and Polymeric Micelle‑based Nanomedicine for Cancer Therapy
<p>Ex vivo gene transfer has been used to improve the outcome of islet transplantation for treating type I diabetes. RNA interference is an effective approach for reducing gene expressions at the mRNA level. The application of RNA interference to improve the outcome of islet transplantation was …
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Innovative formulations for the treatment of Plasmodium infections
Nanomedicine is one of the most innovative strategies to target drugs at the action site and increase their activity index. Phytomedicine is the most traditional method used to treat human diseases and solve health problems. Their combination represents the future prospective to a better care of …
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Precisely size controlled drug-silica nanoconjugate for cancer therapy
… and to identify the optimal size of nanomedicine for the highest anticancer efficacy. I developed a novel drug delivery platform based on drug-silica nanoconjugates (drug-NCs) that can be controllably fabricated with nearly any desired sizes between 20 and 200 nm, with extremely …
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Defining Delivery Pathways of Nanoparticles
The goal of nanomedicine is to use nanoparticles to carry drugs to specific target site in the body. For cancer nanomedicine, a recent meta-analysis showed that only 0.7% of the injected nanoparticles reach the tumour. To address this delivery inefficiency, it is important to examine each …
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The Molecular and Cellular Mechanisms for Nanoparticle Transport
The goal of cancer nanomedicine is to deliver drugs to the tumour using nanoparticles. However, this tumour delivery is not an efficient process. Less than 1% of nanoparticles injected into the blood will reach the tumour while the rest of nanoparticles accumulate in off-target tissues. To improve …
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Dual Receptor Uptake of Low-Density Lipoprotein Docosahexaenoic Acid (LDL-DHA) Elicits Differential Sensitivity Across Breast Cancer Subtypes
We proposed to treat breast cancer with a novel nanomedicine previously shown to be effective in the treatment of primary liver tumors in rats. This nanoparticle is comprised of the low-density lipoprotein which acts as a carrier for the omega-3 fatty acid docosahexaenoic acid (DHA). The LDL-DHA …
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A drug-free theranostic approach for localized and systemic diseases via nanoparticles
The emergence of field of nanomedicine for addressing the biomedical challenges created a toolkit which has been evolving dynamically with the advances in the medicine itself. At the heart of nanomedicine, nanoparticles exist which are envisioned to shift the paradigm of conventional therapy by …
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Design strategies and application of stimuli-responsive nanoparticles for cancer diagnosis and therapy
… and investment have been given in cancer nanomedicine with the hope to reduce drug-associated toxicity by targeting cancer cells in a heterogeneous tumor environment. Nanomedicine is the drug-containing nanostructured construct with a large surface-to-volume ratio, which has plenty of room …
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EGFR-Targeted Polymeric Micelles For Targeted Pc 4-PDT Of Oropharyngeal Tumors
… research objective is to develop an effective nanomedicine platform for targeted delivery of the photosensitizer drug Pc 4 to sites of head and neck cancer to enhance the clinical repertoire of Pc 4-induced photodynamic therapy (PDT) in these malignancies. The specific aims are to: (1) …
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Trigger-responsive nanomedicines through controlled chemistry
… mark a milestone in the formulation of nanomedicine and will have significant impact on nanomedicine platform design as well as their clinical translation. In connection with the dimeric prodrug design, a trigger-responsive amphiphilic polymeric nano-assembly is also explored for cancer …
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