Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"nanofluidic"”.
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Nanofluidic Channels for Biological Separations
Nanofluidic channels are used to separate DNA molecules by length and applications of the channels to other biomolecules are discussed. The problem of separating DNA and biomolecules by length, charge, or other physical characteristics has consumed a tremendous amount of time and resources over the …
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Deep learning for nanofluidic scattering microscopy
… characterization of single biomolecules called Nanofluidic Scatter Microscopy (NSM) has recently been developed by a the Langhammer research group at Chalmers. We have created a machine learning (ML) framework consisting of deep convolutional neural networks such as U-nets, FCNNs, and YOLO in …
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Multiscale computational modeling of nanofluidic transport
… mechanisms of intrinsic molecular interaction in nanofluidic applications. We performed ab initio molecular dynamics to study the nanoscale solvation behavior of selected ions on finite graphene models. The degree of charge transfer between ion and water, and the effect of defects on dynamics and …
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Gate potential control of nanofluidic devices
… of an external gate potential control on the nanofluidic nanochannels was experimentally investigated in this work. Like in the field effect transistors (FET) in microelectronics, molecular transport in micro/nanofluidic channels can be controlled by applying external potentials on the wall of …
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The development of nanofluidic platforms for biomolecular separations
… these separations and purifications in smaller, nanofluidic based systems. This dissertation presents research conducted to explore how fluids, electrical fields, and dissolved analytes of interest (including biomolecules) behave in nanoconfined systems. It presents the recent advances in …
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Hybrid Micro/nanofluidic Sampling Schemes for Mass Spectrometry
… direct chemical analyses. Here, hybrid micro/nanofluidic manipulation schemes are explored and interfaced with mass spectrometry in the effort to study the distribution and dynamic release of neurotransmitters and neuropeptides from individual neurons.
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A coarse grained transport model for nanofluidic systems
Molecular Dynamics (MD) is an important tool to simulate flows at the nanoscale. The limitation of MD in simulating important biological and chemical systems having a large length and time scale, increased the interest in efficient coarse-grained (CG) models. Although many existing CG models for …
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Integrated optic/nanofluidic detection device with plasmonic readout
… integrated fabrication process including glass nanofluidics, diffused waveguides and metal structures was developed. To enable this process a voltage-assisted polymer bond procedure was developed. This bond process enables high strength, robust, optically clear, low temperature bonding of glass …
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Nanofluidic system for single molecule manipulation and analysis
… realized. This work lays the foundations for a nanofluidic device for enhanced measurement resolution through statistical averaging over multiple measurements on the same molecule.
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Computational modeling of biological molecule separation in nanofluidic devices
… simulation tools for modeling the performance of nanofluidic devices for the separation of short, Ogston-regime, dsDNA molecules. The first part of this Thesis focuses on the development of Brownian Dynamics models to predict the electrophoretic velocity of dsDNA molecules in nanoscale separation …
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Nanofluidic devices for rapid analysis of DNA and proteins
… in speed, accuracy, and sensitivity. Nanofluidic systems with critical dimensions comparable to the molecular scale open up new possibilities for direct observation, manipulation and analysis of biomolecules (single or ensemble), thus providing a novel basis for ultra-sensitive and …
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Fabrication of nanofluidic devices using electrochemical etching of sacrificial copper
… and biological research. A method of creating nanofluidic systems with integrated sensor electrodes is presented with a detailed description of the fabrication process. Devices were built by creating nanometer scale copper channels on glass substrates and patterning gold cross channels above …
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Electrokinetic trapping of biomolecules : novel nanofluidic devices for proteomic applications
… To address this issue, we developed a novel nanofluidic concentrator, utilizing the unique concentration polarization effect of sub 50 nm nanofluidic filters. With the distinct ionic and molecular interaction at the nanoscale, nanofluidic systems can potentially outperform current sample …
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Pulsed field separation of biomolecules in a nanofluidic filter array
… separation efficiency of biomolecules in a nanofluidic filter array channel. Separation under pulsed fields was tested using PBR322 DNA, Lambda Hind III DNA, and a sample containing three SDS denatured proteins. Pulsed fields are divided into long pulse and short pulse regimes, depending on …
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Fabrication and testing of silicon integrated nanofluidic channels for neurochemical transport
… structures to measure the performance of the nanofluidic channels without probe integration to determine the root cause of this issue. Upon resolving this issue, we will be able to measure the temporal resolution of various integrated probe designs to optimize the performance of our …
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Ultra-high-aspect-ratio nanofluidic channels for high-throughput biological applications
The development of micro/nanofluidics is expected to be the enabling technology for sample preparation of proteomic biosamples, which has been the bottleneck in proteomics. Most microfabricated nanofluidic channels, such as planar nanochannels and square nanochannels, suffer from small open volume …
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Towards a Single Bio-molecule Detector Based on CMOS Nanofluidic Platform
… (SSN) of size 55nm×162nm×100nm (w×l×h) with nanofluidic access channels that bridge the buffer solution between the assay space in the packaging structure – a poly carbonate/Polydimethylsiloxane (PDMS) package- and the nanopore on the chip. A silicon Single Photon Avalanche Detectors (SPADs) …
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Continuous Antibody Titer Assessment of the Biomanufacturing Process using Nanofluidic Binding Assays
… The objective of this study is to create a nanofluidic device for online monitoring of monoclonal antibody (mAb) titers based on ligand-binding. This system has a small footprint, straightforward operation procedures, and minimal complex data analytics requirements. During manufacturing and …
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Fabrication and characterization of nanofluidic channels for studying molecular dynamics in confined environments
… bonding, in fabricating sub-100-nm thick nanofluidic channels, which will be used for a controlled experimental study of molecular and fluidic transport in confined space. It is found that the fabrication of nanofluidic channels using PDMS substrate is generally limited to the thickness of …
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FABRICATION OF POLYMER NANOFLUIDIC CHIPS WITH PROTON BEAM WRITING AND NANOIMPRINTING FOR DNA LINEARIZATION
Nanofluidic enclosed lab on chip (LOC) devices with nano size patterns and fast fabrication capability are required for biomedical experiments. Nanopatterning and fabrication methods for nanochannel devices are discussed with focusing on proton beam lithography, Ormostamp mold casting, …
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