Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"nanocomplexes"”.
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Amorphous calcium phosphate nanocomplexes in dental film formulations
… exploration of novel amorphous calcium phosphate nanocomplexes stabilised by food grade additives. The concept is to generate a formulation to prevent dental caries through enamel remineralisation, supplementing the calcium and phosphate concentrations by delivery from an adhesive dental film …
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Sustained hydrogel-based delivery of RNA interference nanocomplexes for gene knockdown
… better RNase protection compared to lipid nanocomplexes though Invivofectamine® 3.0 nanocomplexes protected a small percentage of siRNA over 10 days. The MD nanoparticle displayed improved siRNA release and transfection efficacy compared to D but efficacy of the dendrimers was lower than …
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Preparation and Functionalization of Macromolecule-Metal and Metal Oxide Nanocomplexes for Biomedical Applications
Copolymer-cobalt complexes have been formed by thermolysis of dicobalt octacarbonyl in solutions of copolysiloxanes. The copolysiloxane-cobalt complexes formed from toluene solutions of PDMS-b-[PMVS-co-PMTMS] block copolymers were annealed at 600-700 °C under nitrogen to form protective siliceous …
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Targeting extracellular matrix using siRNA for the treatment of liver fibrosis and pancreatic cancer
… hypothesize that cholesteryl peptide/PCBP2 siRNA nanocomplexes modified with targeting and functional polyaminoacids/polypeptides could increase the specificity, delivery efficiency, and therapeutic efficacy. Furthermore, we also developed and evaluated a feasible rat model for alcoholic liver …
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Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
… biodegradable multiblock polymer to form nanocomplexes with VEGF siRNA for TNBC treatment. The nanocomplex is able to deliver the VEGF siRNA into TNBC cells with a high transfection efficiency and low cytotoxicity. In vitro activity studies showed that the siRNA nanocomplexes significantly …
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Tailoring Intermolecular Interactions for High-Performance Nanocomposites
… complexation technique afforded stable ternary nanocomplexes with average hydrodynamic diameters under 100 nm. These ternary nanocomplexes represent promising materials for photothermal cancer theranostics due to their size and stability. The efficient reaction of 2-isocyanatoethyl methacrylate …
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Synthesis, Characterization, and Evaluation of Amphiphilic Cell-Penetrating Peptides as siRNA Delivery Tools for Cancer Therapy
… and MDA-MB231 cells. Oleyl conjugates formed nanocomplexes with siRNA, possibly due to the presence of fatty acyl chain. Also, an increasing number of arginine residues in oleyl conjugated (HR)4 increased cellular uptake with subsequent silencing efficiency of the siRNA. Visual confocal images …
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The development of novel strategies to modulate epithelial sodium channel (ENaC) activity in chronic obstructive pulmonary disease (COPD)
… airway epithelial cell-targeted version of RALA nanocomplexes for the effective targeting of ENaC via local airway delivery holds significant potential.<br/>
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Targeting nucleic acids for pancreatic cancer: disease modeling and therapy
… can complex with siRNA to form tumor-penetrating nanocomplexes (TPNs) effective in delivering siRNA to PDAC. Such a nanoscale carrier could provide a practical means of bridging our understanding of PDAC as a genetic disease to the clinic. Furthermore, the modular aspect of these self-assembled …
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Enhanced physicochemical and functional properties of pea (Pisum sativum) protein by pH-shifting and ultrasonication combined process
… used to prepare nanoemulsions (0.25% oil) and nanocomplexes loaded with vitamin D3 (VD3). Storage stability, photooxidation protective ability, and morphological structure of the PPI-stabilized nano-systems were examined. The pH12+U5 treatment increased the solubility of PPI from 8.17% …
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Materials and biological approach to gene delivery in human embryonic stem cells
… Plasmid DNA was condensed with PVBLG-8 to form nanocomplexes, which were further coated with hyaluronic acid. PVBLG-8 has proven to be an effective gene delivery material in certain cell lines, due to its membrane disruptive properties. Yet in more sensitive cell lines, like hESCs, it proves to …
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Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
… imaging and post euthanized biodistribution of nanocomplexes and found it to be most distributed in liver in comparison to other variants of avidin. In vitro silencing activity and cellular uptake was also significantly higher in case of the neutravidin nanocomplex with negligible lysosomal …
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Novel polyelectrolyte complexes for oral insulin delivery.
… at pH 7.4 resulted in the formation of soluble nanocomplexes. Complexes were characterised by tansmittance measurements, particle size analysis, zeta potential, complexation efficiency and transmission electron microscopy (TEM). Stable polymer-insulin complexes were observed to have hydrodynamic …
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Nanocarriers for nose-to-brain delivery: a novel strategy for the treatment of CNS disorders
… siRNA through electrostatic interaction to form nanocomplexes that were characterized in terms of size, zeta potential and stability. Cell cytotoxicity of the nanocomplex was determined in A431 cell line. Transfection and silencing efficiency were evaluated in vitro and in vivo after IN …
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Discovery of IKBKE and CD24 siRNAs for the treatment of triple-negative breast cancer
… delivery system to condense IKBKE siRNA to form nanocomplexes for the treatment of TNBC. The stability, cellular uptake, and penetration capability of the cholesterol peptide/siRNA (CCP/siRNA) nanocomplex was significantly increased. Importantly, the CCP/siRNA nanocomplex significantly inhibited …
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Synthesis and Evaluation of Carbohydrate Based Cationic Polymers for siRNA Delivery and Tracking
… brain cancer cells. The poly(trehalose) coated nanocomplexes were demonstrated to be substantially effective for quantitative siRNA delivery in presence of high salt concentrations and serum proteins. The ability of trehalose to lower phase transition energy associated with water freezing and …