Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"nanocarriers"”.
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Engineered Polydopamine Nanocarriers for Biomedical Applications
… the field of nanomedicine and the design of drug nanocarriers, several critical challenges persist. These include limited cargo delivery due to uncontrolled drug release, off-target toxicity, premature aggregation, and rapid clearance of nano-formulations. Among the nanomaterials explored, organic …
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Polysaccharide-Based Nanocarriers for Improved Drug Delivery
… In this study, we developed PSA-based nanocarriers, specifically micelles and nanoparticles, for improved drug delivery with improved efficacy and minimized toxicity. PSA-based micelle systems were developed via conjugation with two hydrophobic groups, decylamine (DA) and …
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SMART POLYMERIC DRUG NANOCARRIERS FOR BIOMEDICAL APPLICATIONS
Biodegradable polymeric nanoparticles (nps) have shown to be promising forms for the delivery of a wide array of drug formulations, because of their ability to: (i) increase the drug half-life in the blood stream, (ii) enhance the solubility of poorly-water soluble drugs, which represents the main …
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Polymeric nanocarriers with dendritic core-shell architectures
Hyperbranched polymers, polyglycerol and polyethylenimine, were functionalised in order to tailor systems that can be used in medical applications. The systems described in this thesis can be used for pH controlled release of drug molecules and were also investigated towards their gene transfection …
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Nanocarriers for drug targeting and improved bioavailability
This PhD thesis debates, mostly, on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 …
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Anti-Obesity Effects of Adipose-Targeting Resveratrol Nanocarriers
… and biodegradable R encapsulated lipid nanocarriers (Rnano), and R encapsulated liposomes (Rlipo) (Chapter IV). The mean particle size of Rnano and Rlipo were 140 nm and 110 nm, respectively, and both nanoencapsulation significantly increased aqueous solubility and enhanced chemical …
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Zein nanocarriers for bioactive ingredients encapsulation and delivery
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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MicroRNA Nanocarriers for the Treatment of Chronic Obstructive Pulmonary Disease
Chronic obstruction pulmonary disease (COPD) is a major cause of morbidity and mortality across the world. COPD is currently the fourth leading cause of death in the world and is predicted to become the third leading cause of chronic illness and death worldwide by 2030. There are several …
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Development of siRNA transporter nanocarriers for the regulation of inflammation
Η κατανόηση των μοριακών μηχανισμών που διέπουν τις χρόνιες φλεγμονώδεις αποκρίσεις αποτελεί έναν από τους κεντρικούς πυλώνες της σύγχρονης βιοϊατρικής έρευνας. Η απορρύθμιση των δικτύων κυτταροκινών παίζει καθοριστικό ρόλο στην παθογένεια πλήθους ασθενειών, με ιδιαίτερη έμφαση στις Ιδιοπαθείς …
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Novel nanocarriers to improve drug delivery for age-related macular degeneration
Visual impairment affecting the posterior segment of the eye is a significant health problem causing a deterioration of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on a global scale as one of the major back-of-the-eye disorders being responsible …
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Polyethylene glycol copolymer nanocarriers: Biocompatibility, uptake and intracellular trafficking in neurons
… nanomaterial-based drug delivery systems (nanocarriers) are promising excipients for targeted drug delivery to neurons. We have developed four types of nanocarriers and performed experiments to further optimize their potential use in SCI treatment. One of them is a polymer (PEG copolymer) …
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Ocular Iontophoresis of Nanocarriers for Sustained Drug Delivery to the Eye
<p>Transscleral iontophoresis has been shown as a viable modality to deliver therapeutic drugs for the treatment of eye diseases. Although several studies have been conducted to examine the utility of iontophoresis for both charged and neutral molecules, the understanding of the mechanisms …
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Targeted Drug Delivery with Cyclodextrin-based Nanocarriers and Focused Ultrasound Triggering
Background: The Nanoporation project set out to explore specific solutions to overcome the current challenges of targeted drug delivery (TDD) to tumours using magnetic resonance imaging guided focused ultrasound (MRgFUS) to cavitate microbubbles (MBs) for increasing cell permeability and to open …
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The Design of Biodegradable Polyester Nanocarriers for Image-guided Therapeutic Delivery
… of many promising therapeutics. Polymeric nanocarriers can encapsulate the therapeutics to protect non-target areas from side effects but also protect the drug from premature degradation for increased circulation and bioavailability. To capitalize on these advantages, the polymer …
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Development of Polymeric Nanocarriers for Dual Magnetic Resonance Imaging and Drug Delivery
Two types of (polymer-imaging agent-drug) complexes were prepared and characterized. These included block and graft copolymer complexes with magnetite nanoparticles and manganese ions. Magnetite block ionomer complexes (MBICs) were formed through binding of a portion of the anionic segment of …
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Engineering bacteriophage nanocarriers for targeted delivery of protein reagents to prostate cancer cells
Proteinaceous reagents, including antibodies and synthetic proteins, have become some of the most effective reagents for targeted treatment and diagnosis of disease. The unique catalytic activity of some proteins and ability to bind disease-relevant receptors that can evade small molecule …
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