Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"naloxone"”.
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Intranasal Naloxone Adminstration Education
… on the provision of education on intranasal naloxone administration to healthcare providers in Lake County in order to educate patients, their families, peers, and members of their social network. Fatal opioid overdose rates from prescribed or illicit opioids are four times greater in Lake …
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Exploring the perceived barriers and facilitators to equitable access of Naloxone in Durham Region: A pilot study
… exploratory case study research, we examined naloxone distribution from community pharmacies and perspectives of service providers about barriers and facilitators to equitable access of naloxone through the Ontario Naloxone Program (for Pharmacies) in Durham Region, Ontario, Canada. The impact …
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People with active opioid use disorder as first responders to opioid overdoses: Improving implementation intentions to administer naloxone
… particularly for people who use opioids (PWUO). Naloxone is an opioid antagonist crucial to reducing opioid overdose mortality. Inconsistencies exist among PWUO in obtaining, carrying, discussing, and administering naloxone. Using sequential mixed methods, this study was aimed at investigating …
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Effects of opioid antagonism on thermoregulation during prolonged exercise in the heat
… were conducted following the administration of naloxone (4mg IV) 5 minutes prior to exercise with a follow-up 4mg dose at 25 minutes of exercise. In the placebo trial, volume-matched doses of saline were administered at the same points. No significant drug effect was observed on rectal or mean …
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Opioid regulation of ingestive behavior in the domestic fowl
… relationships of two opioid antagonists, naloxone and naltrexone, were evaluated in Rock-Comish (RC) and Single-Comb White Leghorn (SCWL) cockerels. Naloxone and naltrexone decreased food and water intake in both stocks. In a separate experiment, the effect of naloxone on water intake was …
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Effect of naloxone on serum luteinizing hormone concentrations during the early postpartum period and the estrous cycle in primiparous and multiparous holstein cows
… were conducted to investigate the effect of naloxone, an opioid receptor antagonist, on pituitary LH secretion in Holstein cows during two periods after parturition and two phases of the estrous cycle. In experiment 1, 24 cows (12 primiparous; 12 multiparous) received either saline (n = 12) …
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The role of the endogenous opioid system in thermoregulation during exercise
… subjects received either placebo, 2mg or 10mg naloxone hydrochloride in a randomized double-blind crossover fashion prior to the exercise test. Rectal temperatures were recorded at one-minute intervals and cardiorespiratory parameters were measured during the test. Water loss was calculated …
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New Jersey Overdose Prevention Act: Police Officers’ Experiences At A Drug Overdose Scene
… Overdose Prevention Act (NJOPA) and the use of naloxone by first responders are ways that state officials try to save lives. However, there is limited research on the first responders’ experiences, specifically the police officers’ experiences, who administer naloxone and follow the NJOPA. …
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Reducing opioid overdose-related deaths in Michigan : a policy analysis
… (Larsona & Bergmans, 2022). The availability of naloxone, a medication used to reverse opioid overdoses, is lacking throughout the state of Michigan and has further contributed to the rise of opioid related overdoses. In recent years the state of Michigan has positioned itself to reverse current …
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Visualizing global drug flows : transnational connections to the overdose crisis in New England, USA
… (IMF), a powerful synthetic opioid; and (b) naloxone, an opioid overdose antidote used in the public health crisis of drug overdose deaths in Massachusetts, USA. Beginning locally in Massachusetts, I filmed parents reflecting on losing children to overdoses, first responders administering …
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Self-Stimulation and Morphine Abstinence in the Rat.
… with either a morphine or placebo pellet. Naloxone or saline was administered 48 hours later and animals were observed briefly for abstinence behaviors. Immediately following the observation period, animals were tested in the shuttlebox. Of the ten animals undergoing naloxone-precipitated …
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Engineering a microneedle patch for opioid overdose therapy
… presents a critical challenge to public health. Naloxone hydrochloride, a μ-opioid receptor antagonist, is the frontline therapeutic for overdose reversal; however, its clinical utility is constrained by rapid clearance, frequent re-dosing requirements, and complications associated with …
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The Effect of Centrally Administered D-Alanine-Methionine-Enkephalinamide (Dala) on the Copulatory Behavior of Male Hamsters
… DALA was administered ICV. One day 15, 4mg/kg of Naloxone, a competitive opiate antagonist was given intraperitoneal (IP) 10 minutes before DALA ICV. Ten minutes after each administration of DALA, males were exposed to estrus females for 50 minutes and their copulatory behavior observed. …
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Hormonal and metabolic responses to opioid antagonism during dynamic exercise : influence of exercise intensity
… the administration of the opiate antagonist naloxone (NAL) (0.1 mg-kg-1 bolus + 0.1 mg-kg-1-·hr-1) or volume matched saline (SAL). Serum glucose was maintained at significantly higher levels at 60 and 90 minutes of exercise in 70% NAL vs 70% SAL. Serum glucose was significantly higher at all …
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Um modelo de comportamento aversivo térmico em Megalobulimus oblongus e a ação de fármacos nos sistemas opióide e serotoninérgico envolvidos na nocicepção
… ou 5-HT), e dos bloqueadores, o naloxone e a metisergida. Com o procedimento utilizado, foi posível diferenciar um comportamento estereotipado indicativo de resposta à nocicepção, determinar a latencia em que tais comportamentos são inicialmente manifestados, e as alterações …
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The basis of analgesic activity of four Chinese herbs.
… the aqueous Gou extract and tritium-labelled naloxone. For very small quantities of Gou there was a lowering of naloxone binding showing the antagonistical action of Gou. At higher concentrations (> 4 mg/ml of Gou) there was a tendency for naloxone binding to increase demonstrating potential …
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Pharmacological Characterization of Novel Opioid Receptor Ligands Aimed at Reducing the Development of Tolerance
… assays, comparable to morphine itself. Naloxone, a non-selective opioid antagonist, and nor-BNI, a selective kappa-antagonist, pretreatment studies were performed to ensure proper opioid-induced analgesic mechanisms. Naloxone attenuates the analgesic effects induced by an acute ED90 of …
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Regulation and site of action of exogenous and endogenous opioids on growth hormone and prolactin secretion in Holstein calves
… with either the lipid soluble opioid antagonist naloxone (NAL), which readily penetrates the blood brain barrier (BBB), or the peripherally acting antagonist methyl levallorphan mesiltate (MLM), blocked the PRL response to DAMME. Naloxone, but not MLM, negated the GH response to DAMME. In spring, …
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Regulation of Luteinizing Hormone and Catecholamine Release
… studies tested whether the opiate antagonist, naloxone, which increases LH release, enhances the activity of NE and EPI neurons in the hypothalamus, and also tested whether morphine, an opiate agonist which decreases LH release, depresses the activity of hypothalamic NE and EPI activity. …
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Metabolic signalling and neuroendocrine stress responses in pregnancy
… with the opioid receptor antagonist naloxone reinstated the ACTH response and restored CRH and AVP mRNA responses. Naloxone administration revealed that endogenous opioids facilitate NPY-induced feeding in both virgin and late pregnant rats, but more importantly in late pregnant rats. …
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