Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"naked mole rat"”.
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Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat
The naked mole-rat (NMR, Heterocephalus glaber) is a highly unusual mammal: eusocial, cold-blooded and with remarkable resistance to hypoxia, hypercapnia and acid-induced pain. Furthermore, NMRs are exceptionally long-lived and extremely cancer resistant. Few studies have attempted to explain the …
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DNA Damage Response in Huntington’s Disease and Naked Mole Rat Brain Ageing
This thesis investigates the molecular mechanisms underlying healthy brain ageing in the exceptionally long-lived naked mole rat (NMR) and the role of the DNA damage response in the pathogenesis of Huntington's disease (HD). Multi-omic analyses of NMR brain ageing revealed a lack of a canonical …
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Hormonal aspects of reproductive suppression in the naked mole-rat, Heterocephalus glaber
Subordinate, female naked mole-rats (Heterocephalus g/aber) are anovulatory as a result of extremely low luteinising hormone (LH) levels. Evidence suggests that aggression from the dominant female naked mole-rat directed towards subordinates could produce these lowered levels of LH. This study …
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Social suppression of reproduction in the naked mole-rat, Heterocephalus glaber : -Plasma LH concentrations and differential pituitary responsiveness to exogenous GnRH
The naked mole-rat provides possibly the most extreme example of socially-induced reproductive suppression observed in any mammal. The majority of colony members remain reproductively suppressed for their entire lives, nevertheless they are not sterile, and can become reproductively active soon …
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Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation
Keratinocyte carcinomas (KCs) are the most common cancers globally. Ultraviolet light is the key risk factor for these cancers but sunscreen has proven ineffective in their prevention, indicating a need for new prophylactic agents. Chronic elevation of high molecular weight (HMW) tissue hyaluronan …
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The gonadotropin-releasing hormone (GnRH) system: a comparison between breeding and non-breeding naked mole rats (Heterocephalus glaber)
… is the hypophyseal-portal system found in vertebrates, and one of the functions of this system is to mediate reproduction. Mammalian reproduction is controlled by a hormonal cascade which begins in distinct brain regions, namely the hypothalamus and the pituitary gland. Gonadotropin-releasing …
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Profiling extracellular vesicles signatures and deiminated protein cargo across phylogeny and pilot assessment of in vitro application of EVs in tissue regeneration, with focus on selected taxa displaying unusual immunological properties.
… in a hypoxia-resistant species, such as the naked mole-rat, identifies pathways linking the brain citrullinome alterations to changes in circulatory EV profiles. Moreover, the thesis explores the regenerative potential of EVs derived from Atlantic cod mucus and serum. Proteomic analysis of …
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Characterisation of Small Ubiquitin-like Modifier (SUMO) protein complex expression in human cancer cells to identify novel therapeutic targets
… essential for cancer cell survival and proliferation. The unique behaviours, phenotypic and molecular adaptations found in the naked-mole rat (NMR) suggest a high stability and effective functioning of the molecular machinery that counteracts damage accumulation in its genome. NMR can reach 32 …
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Probing the protein homeostasis mechanisms in long-lived naked mole-rats
The naked mole-rat (NMR) is a fascinating animal which has unique biological features including eusociality, strict subterranean inhabitation and poikilothermy. It is the longest-living rodent, showing negligible senescence over the majority of its lifespan and high resistance to diseases such as …
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Proton-sensing G protein-coupled receptor signalling in inflammation
… is thus considerable interest in elucidating the molecular mechanisms underlying inflammatory pain. Animal studies represent a valuable tool for studying the complexities of inflammation, which involves a concert of cell types. However, the interplay between changes at the cellular level and the …
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Functional anatomy, osteogenesis and bone microstructure of the appendicular system of African mole-rats (Rodentia: Ctenohystrica: Bathyergidae)
… aspects, the skeletal system of African mole-rats (Bathyergidae) has been relatively understudied. Only a few studies have assessed their skeletal system, but these have mostly focused on their cranial and dental systems, with little attention on their postcranial skeleton. This PhD …