Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"naive CD4 T cells"”.
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Development of an oral DNA anti-cancer vaccine targeting an angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
… at 2-week intervals. Then, B16-F10 melanoma cells were injected either into the tail vein to generate lung metastases or subcutaneously to generate cutaneous melanoma. Furthermore, naive CD4+ T cells were exposed to PAMP, and their secretome was analyzed by proximity extension assays. …
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Inhibition of IFN-[gamma] promoter function by site-specific methylation
When they become activated, naive helper T cells are able to polarize into either THI cells or TH2 cells. Development of naive CD4+ T cells into TH1 cells is characterized by the expression of IFN-y and the silencing of IL-4, while development into TH2 cells is characterized by expression of IL-4 …
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The Role of Alternative Splicing and Alternative Polyadenylation in Regulating Activated T cell Biology
… or association with other factors. T cells provide a unique model to study RNA processing events, such as alternative splicing and polyadenylation, due to the dynamic and robust changes in isoform usage induced upon activation. However, detailed characterization of the regulation of …
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A framework for understanding heterogeneous differentiation of CD4⁺ T cells
CD4+ T cells are a group of lymphocytes that play critical roles in the immune system. By releasing cytokines, CD4+ T cells regulate other immune cells for maximizing the efficiency of the system. Naive CD4+ T cells are activated and become mature upon engagement with antigens, and the mature CD4+ …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
… research at GSK, that there is a population of CD4+ lymphocytes with apparent constitutive pSTAT1 expression independent of any stimulus and refractory to JAK-1 inhibition. This pSTAT1hi population had been found to be enriched in patients with systemic lupus erythematosus. The starting …
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Signal specificity amongst STAT1- and STAT3- inducing cytokines in the context of Th17 differentiation
… mediators of the adaptive immune response are CD4+ T cells, which depending on the cytokine milieu, and the activating conditions during antigen recognition, can differentiate into different effector T cells. One particular type of effector T cell, Th 17, is highly inflammatory and has been …
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Contact-Dependent Activation of Macrophages by Naive CD4<sup>+</sup> T cells.
<p>Naive T cells are positioned at the origin of adaptive immune responses. The activation of naive T cells is usually viewed from the perspective of IL-2 production and entry into the cell cycle. This activation is antigen specific and MHC restricted via TCR ligation/CD3 signaling but also demands …