Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"nNOS inhibitors"”.
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Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
… suggests that neuronal nitric oxide synthase (nNOS)-mediated nitric oxide (NO) signaling is crucial for melanoma progression and forms a mechanistic rationale behind nNOS inhibition as a novel treatment strategy for CM. An additional study demonstrated that IFN-γ interacts with nNOS signaling …
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A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease
… NO, produced by neuronal nitric oxide synthase (nNOS), contributes to the occurrence and evolution of dyskinesia in PD. Therefore, these studies investigated the effects of nNOS inhibition, using the nNOS inhibitors ARR17477 and 7-nitroindazole (7-NI), on the dyskinesia expression and priming …
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Development of Pharmaceutical Inhibitors Targeting nNOS for Melanoma Treatment
… from immune surveillance. Immune checkpoint inhibitors targeting PD-1/PD-L1 have been shown to prevent immunosuppression and exhibited significant clinical benefits in improving patient survival across a broad range of cancer types including melanoma. Of note, our preliminary RPPA study …
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Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment
… over the years. Neuronal nitric oxide synthase (nNOS) produces nitric oxide (NO) has been found to be overexpressed in human melanoma and the expression of nNOS is induced by interferon-gamma (IFN-γ). In our studies, nNOS has been implicated in IFN-γ-stimulated melanoma progression and the …
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Expression, inhibition and in silico modelling of human neuronal nitric oxide synthase
… (eNOS), inducible NOS (iNOS) and neuronal NOS (nNOS). eNOS is constitutively expressed in the circulatory system, while iNOS is inducibly expressed in response to cellular invasion by a pathogen. nNOS, which was the isoform targeted in this work, is constitutively expressed in the brain and …
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Potential Prodrugs of the Neuronal Nitric Oxide Synthase and Monoamine Oxidase Inhibitor 7-Nitroindazole and Structurally Related Compounds
… the neuronal form of nitric oxide synthase (nNOS) and monoamine oxidase B (MAO-B), have been linked to neurodegenerative pathways leading to PD. Several MAO-B and nNOS inhibitors have been evaluated for their neuroprotective properties in the mouse model of neurodegeneration which employs the …