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Showing 1 to 20 of 39 for “"nNOS"”.

  1. Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression

    Lozada, Kate Alison2024

    … suggests that neuronal nitric oxide synthase (nNOS)-mediated nitric oxide (NO) signaling is crucial for melanoma progression and forms a mechanistic rationale behind nNOS inhibition as a novel treatment strategy for CM. An additional study demonstrated that IFN-γ interacts with nNOS signaling …

    chapman Repository record

  2. Development of Pharmaceutical Inhibitors Targeting nNOS for Melanoma Treatment

    Patel, Anika R2027

    … our previous studies demonstrated that novel nNOS inhibitor HH044, effectively inhibited IFN-γ-induced PD-L1 expression both in vitro and in vivo. Another objective of this study was to determine whether nNOS-mediated nitric oxide (NO) signaling interacts with the COX-2-PGE2-PD-L1 signaling …

    chapman Repository record

  3. Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment

    Tong, Shirley2024

    … over the years. Neuronal nitric oxide synthase (nNOS) produces nitric oxide (NO) has been found to be overexpressed in human melanoma and the expression of nNOS is induced by interferon-gamma (IFN-γ). In our studies, nNOS has been implicated in IFN-γ-stimulated melanoma progression and the …

    chapman Repository record

  4. NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation

    Patel, Jheel2021

    … NMDARs recruits neuronal nitric oxide synthase (nNOS) to the synaptic scaffolding protein, postsynaptic density protein 95 (PSD95), to produce nitric oxide (NO). Our laboratory has previously shown that disruption of the PSD95-nNOS interaction attenuates fear consolidation and impairs long-term …

    iupui Repository record

  5. Cell death of reelin secreting nNOS positive GABAergic interneurons in the hippocampus of P301L trangenic mice

    김, 남중2015

    … 중에서 해마에서는 neuronal nitric oxide synthases (nNOS)를 발현하는 GABA성 신경세포가 가장 높은 비율로 존재하고 있다. 이러한 GABA성 신경세포의 생존에 있어서 Tau의 인산화가 중요한 역할을 담당하고 있으며, 그렇기 때문에 본 연구에서는, FTDP-17 (Frontotemporal dementia and parkinsonism linked to chromosome 17) 질환 모델로서 Tau 단백질의 과인산화를 유도한 P301L 생쥐를 이용하여 해마 (hippocampus)에서 …

    ajou Repository record

  6. A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease

    Hirsch, TamaraKing's College London2012

    … NO, produced by neuronal nitric oxide synthase (nNOS), contributes to the occurrence and evolution of dyskinesia in PD. Therefore, these studies investigated the effects of nNOS inhibition, using the nNOS inhibitors ARR17477 and 7-nitroindazole (7-NI), on the dyskinesia expression and priming …

    kings Repository record

  7. Expression, inhibition and in silico modelling of human neuronal nitric oxide synthase

    Curtin, AdamNational University of Ireland Maynooth2015

    … (eNOS), inducible NOS (iNOS) and neuronal NOS (nNOS). eNOS is constitutively expressed in the circulatory system, while iNOS is inducibly expressed in response to cellular invasion by a pathogen. nNOS, which was the isoform targeted in this work, is constitutively expressed in the brain and …

    maynooth Repository record

  8. Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum

    Jassal, GurneetThe University of Western Ontario2022

    … oxide (NO) via neuronal nitric oxide synthase (nNOS). Previous studies demonstrate that nNOS/NO signaling is crucial for PF-PN synaptic transmission. This study sought to examine nNOS/NO signaling regulation of excitatory amino acid transporter 4 (EAAT4) on PN dendrites and glutamic acid …

    uwo Repository record

  9. The Study of Nitric Oxide Synthase Expression, Function, and Regulation in the Renal Vasculature During Postnatal Renal Development

    Ratliff, Brian Blake2019

    … synthase (NOS) isoforms, specifically eNOS and nNOS, are developmentally regulated, but their specific role and regulation are unknown.</p> <p>The enhanced vasodilatory role of NO in the immature kidney was hypothesized to be attributed to regulatory, expressional, and functional differences in …

    odu Repository record

  10. Untersuchung der funktionellen Interaktion zwischen der sarkolemmalen Calcium-ATPase und der neuronalen NO-Synthase

    Telkamp, MyriamUniversität Würzburg

    … und Inhibitor der neuronalen NO-Synthase (nNOS) in Kardiomyozyten identifiziert werden. PMCA und nNO-Synthase kommen in Caveolae von Kardiomyocyten vor. Humane PMCA4b überexprimierende Rattenherzen zeigen ex vivo eine signifikant höhere cGMP-Konzentration als wildtypische Rattenherzen. Das …

    wurz-thes Repository record

  11. Interaction between Adrenergic and Nitric Oxide-releasing Nerves in Cerebral Arteries

    Mbaku, Emmanuel Ngu

    … of endogenous NO which is synthesized by nNOS, reveals that NO exhibits numerous and wide spread interactions in the nervous system with implications in disease conditions such as Multiple Sclerosis, Schizophrenia, Parkinson’s and Alzheimer’s diseases. On the other hand, beneficial effects …

    loma-linda Repository record

  12. Genetically encodable calcium sensors for Magnetic Resonance Imaging

    Ghosh, Souparno, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2018

    … enzyme, neuronal nitric oxide synthase (nNOS). We show that chemical stimulation of ectopically expressed neuronal nitric oxide synthase (nNOS) elicits an artificial hemodynamic response detectable by MRI. To distinguish signaling from endogenous nNOS we use a two-prong strategy to …

    mit Repository record

  13. Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex in skeletal muscle

    Judge, Luke Milburn2006

    … molecule neuronal nitric oxide synthase (nNOS) to the DGC, and specific parts of the dystrophin rod domain not found in utrophin were shown to participate in localization of nNOS. However, association of nNOS with the DGC was not required for amelioration of dystrophy. The results suggest …

    washington Repository record

  14. Physiological adaptations in mdx mice treated with microdystrophin gene therapy and endurance exercise

    Hamm, Shelby ElizabethVirginia Tech2022

    … in clinical trials. Construct 1 contained the nNOS-binding site found in full-length dystrophin, which localizes nNOS to the sarcolemma and reduces functional ischemia of exercising limb muscles, while construct 2 lacked the nNOS-binding site and was the same microdystrophin used in the …

    vt Repository record

  15. Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier

    Isin, Emre MehmetVirginia Tech2004

    The neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) protects against the neurotoxicity of MPTP in a mouse model of neurodegeneration. Since 7-NI also inhibits the monoamine oxidase-B (MAO-B) catalyzed bioactivation of MPTP, the role of nNOS inhibition as a mediator of 7-NI's …

    vt Repository record

  16. A biochemical and molecular analysis of functional differences between dystrophin and utrophin

    Belanto, Joseph John2013

    … cannot bind neuronal nitric oxide synthase (nNOS) even though dystrophin binds nNOS, establishing for the first time a functional difference between dystrophin and utrophin. Here, we show that transgenic overexpression of utrophin on the mdx mouse background (Fiona-mdx) is not sufficient to …

    umn Repository record

  17. Calcium-dependent mechanisms in the chicken retina

    Tekmen, MerveBiological Sciences2022

    … neuronal and endothelial nitric oxide synthases (nNOS; eNOS) is another Ca2+-dependent mechanism in the retina. In the chicken retina, I demonstrate the cell-autonomous nature of the NO signal by comparing the pattern of NO production to the expression of NOS. The NO indicator fluorescence dye, …

    lsu-thes Repository record

  18. Effects of Advancing Age on ER Calcium Regulation in Rat Superior Cervical Ganglia

    Vanterpool, Conwin Kodel

    … on modulators such as phosphorylation, and nNOS protein expression levels were analyzed for changes with age. There were no significant changes in the phosphorylation of the total RyRs with age. However, there was a significant increase in nNOS production from 6 months to 12 months and …

    loma-linda Repository record

  19. Potential Prodrugs of the Neuronal Nitric Oxide Synthase and Monoamine Oxidase Inhibitor 7-Nitroindazole and Structurally Related Compounds

    Isin, Emre M.Virginia Tech2000

    … the neuronal form of nitric oxide synthase (nNOS) and monoamine oxidase B (MAO-B), have been linked to neurodegenerative pathways leading to PD. Several MAO-B and nNOS inhibitors have been evaluated for their neuroprotective properties in the mouse model of neurodegeneration which employs the …

    vt Repository record

  20. Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery

    Overend, JillUniversity of Glasgow2007

    … by eNOS, but not the nitrergic vasodilatation by nNOS. Indeed, the ability of L-NMMA to protect nitrergic dilatation against blockade by L-NAME in a manner similar to L-arginine, suggests it might act as an alternative substrate for nNOS in this tissue. 11.Isoform-selective inhibitors of NOS are …

    glasgow Repository record

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