Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"nACHRs"”.
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The role of subunit interfaces in the function of (α4β2)2β2 nAChRs
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels formed from homologous subunits, of which there are many different subtypes. The ability to combine different types of subunits into an individual pentamer enables a wide diversity of functional properties to meet a …
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The role of high affinity nicotinic acetylcholine receptors on anxiety-like behavior: a study in female mice
… of nicotinic acetylcholine receptors (nAChRs) on anxiety-like behavior. β2*nAChRs (*denotes assembly with other subunits) are the most abundantly expressed nAChRs in the brain yet little is known about the contributions of β2*nAChRs on anxiety-like behavior in female mice. In this …
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Neuronaalisten kolinergisten nikotiinireseptorien positiivinen ja negatiivinen allosteerinen modulaatio
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channel receptors which are widely distributed in human brain. nAChRs are often expressed pre-synaptically and they modulate the release of other neurotransmitters. nAChRs consist of five subunits: nine different subunits have been …
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Studies of nicotinic acetylcholine receptors containing α4 and α6 subunits in nicotine-induced synaptic plasticity in brain reward areas
… desensitizes nicotinic acetylcholine receptors (nAChRs) throughout the brain. nAChRs in ventral tegmental area (VTA) dopamine (DA) neurons are crucial for the rewarding and reinforcing properties of nicotine. Nicotine causes cellular changes in VTA DA neurons, including the enhancement of AMPA …
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Ruolo del peptide β-Amiloide nella sinapsi in condizioni fisiologiche e nella malattia di Alzheimer: interazioni con i recettori a7-nAChRs e i nucleotidi ciclici
La Malattia di Alzheimer (AD) è una patologia neurodegenerativa che rappresenta la più comune forma di demenza nell’anziano. Purtroppo, nonostante decenni di ricerca, la fisiopatologia dell’AD non è ancora stata compresa e non sono disponibili terapie efficaci. L'aumento del peptide …
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BETA 2 NICOTINIC ACETYLCHOLINE RECEPTOR CONTRIBUTIONS TO ANXIETY-LIKE BEHAVIOR
… behavior via nicotinic acetylcholine receptors (nAChRs) in the brain. Given reports that people smoke to relieve anxiety and that anxiety precipitates relapse, the overarching goal of this dissertation research is to assess beta 2 subunit containing nAChR (beta2*nAChR) contributions to …
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THREE-FINGER TOXINS AS SELECTIVE PROBES TO DISTINGUISH SUBUNIT INTERFACES OF NICOTINIC ACETYLCHOLINE RECEPTORS
… postsynaptic nicotinic acetylcholine receptors (nAChRs). For the first time, the cryo-EM structure of a natural ?-neurotoxin, Erabutoxin-A (Ea), complexed with Tetronarce californica nAChR has been elucidated. From the atomic model, in silico Ea mutants at the nAChR binding interface were used to …
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THE MECHANISMS AND PHARMACOLOGY OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN THE CENTRAL NERVOUS SYSTEM
Neuronal nicotinic acetylcholine receptors (nAChRs) are key players in both cognitive and autonomic processes. In the cognitive domains of the brain, destruction of cholinergic inputs or disruption of nAChR function result in cognitive deficits as observed in Alzheimer's disease, schizophrenia, …
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Charakterisierung präsynaptischer Nicotinrezeptoren im Neocortex von Ratte und Mensch
… präsynaptischer neuronaler Nicotinrezeptoren (nAChRs) auf noradrenergen und cholinergen Neuronen im Neocortex von Mensch und Ratte, sowie am Hippocampus der Ratte. Als Methode wurde die durch Stimulation mit nicotinischen Agonisten evozierte Freisetzung von [³H]-Noradrenalin (NA) bzw. …
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The role of Lynx1, an endogenous modulator of cholinergic transmission, in NMJ development, maintenance, and repair
… Lynx1, a GPI-anchored protein shown to modulate nAChRs in the brain, is present and affects the activity of nAChRs at NMJs. Molecular and cellular analysis revealed that Lynx1 levels increase in skeletal muscles, specifically at NMJs, during development. Its expression pattern also closely …
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Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα
… there is an interaction between PPARα and nAChRs in VTA DA cells: particularly, to characterize the postsynaptic effects of PPARα modulation on VTA DA neurons, and to examine the contribution of nAChRs in the effects. 3) To study whether PPARα modulation of nAChRs in VTA DA neurons might …
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Regulation of Expression and Function of Neuronal Nicotinic Receptors by Accessory Subunits
… binds to nicotinic acetylcholine receptors (nAChRs) and perturbs the biogenesis and trafficking of these channels. The α4β2 and α3β4 subtypes are the most abundantly expressed nAChRs in the central and peripheral nervous system, respectively, and are key mediators of nicotine dependence and …
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INVESTIGATING THE ROLE OF α6 and α4 CONTAINING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN NICOTINE AND COCAINE CONDITIONED PLACE PREFERENCE TESTS IN MICE.
… CNS and previous work has demonstrated that β2* nAChRs are involved in nicotine and cocaine reward. α6β2* and α4β2* nAChRs are highly expressed in midbrain, which is known to be critical for the incentive salience associated with natural and artificial (drug) reward. Our goal was to assess the …
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Σχεδιασμός, έκφραση και δομικές μελέτες τμημάτων του ανθρώπινου νευρωνικού νικοτινικού υποδοχέα ακετυλοχολίνης
Οι νικοτινικοί υποδοχείς ακετυλοχολίνης (nAChRs) ανήκουν στους υποδοχείς Cys-θηλιάς, που διαμεσολαβούν και ρυθμίζουν την ταχεία συναπτική νευροδιαβίβαση. Είναι πενταμερή κανάλια ιόντων που ενεργοποιούνται από προσδέτη και απαρτίζονται από πέντε ομόλογες υπομονάδες, καθεμία εκ των οποίων …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
… of neuronal nicotinic acetylcholine receptors (nAChRs) is considered to be one of the most promising approaches for therapeutics. By binding to a site of the receptor distinct from the neurotransmitter binding site, allosteric modulators alter the response of the receptors to their agonists. …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
… of neuronal nicotinic acetylcholine receptors (nAChRs) is considered to be one of the most promising approaches for therapeutics. By binding to a site of the receptor distinct from the neurotransmitter binding site allosteric modulators alter the response of the receptors to their agonists. …
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Engineering and functional characterisation of pentameric concatenated (alpha 4)2 (beta 2)3 and (alpha 4)3 (beta 2)2 nicotinic acetylcholine receptors
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that influence neurotransmitter release, hence constituting a key component of the physiological mechanisms of neuronal signalling. This thesis is concerned with the properties of the a4P2 nAChR, the most abundant …
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Neuronal Nicotinic Receptor Dynamics in Medial Geniculate Body Neurons of Young and Aged Fischer Brown Norway Rats
… of these studies is to examine the location of nAChRs in the local MGB circuitry, their subunit composition, physiology, and how these properties are impacted with age. We have found that ACh produces significant excitatory postsynaptic actions on young MGB neurons, likely mediated by …
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The role of subunit interfaces in the function of nicotinic acetylcholine receptor
… as cognition, mood, reward and analgesia. α4β2 nAChRs have been implicated in a wide range of diseases such as depression, Alzheimer’s, Parkinson’s, Schizophrenia and a type of familial epilepsy. Also, α4β2 nAChRs are necessary and sufficient for the rewarding and reinforcing effects of …
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Role of Microglial α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator in Neuroinflammatory Pain Models in Mice
… cells and α7 nicotinic acetylcholine receptors (nAChRs). Given the role of microglial α7 nAChRs in neuroinflammation, the α7 nAChRs have emerged as potential target for neuroinflammatory pain treatment. We hypothesized that microglial α7 nAChRs positive allosteric modulation in the hippocampus …
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