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Showing 1 to 19 of 19 for “"n. fowleri"”.
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Studies on the Molecular Biology of Naegleru Fowleri and Identification of N. Fowleri in the Environment
Naegleria fowleri, a free-living ameboflagellate, is the causative agent of primary amebic meningoencephalitis. Healthy humans sporadically become infected with N. fowleri and develop fatal PAM after recreational or work exposure to freshwater; accordingly, there is a need for monitoring the …
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A COMPARATIVE STUDY OF A PATHOGENIC VERSUS A NONPATHOGENIC NAEGLERIA SPECIES
Naegleria fowleri (N. fowleri) and Naegleria lovaniensis (N. lovaniensis) are closely related amebae found in the environment. N. fowleri causes Primary Amebic Meningoencephalitis (PAM), a fatal disease of the central nervous system, while N. lovaniensis is nonpathogenic. N. fowleri infection …
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Knockdown of nfa1 Gene Cloned from Naegleria fowleri by Antisense RNA
PAME caused by N. fowleri is an acute, fulminant, and rapidly progressing fatal illness that usually affects children and young adults. There have been few reports to address proteins functioning in vitro cytotoxicity of N. fowleri. The nfa1 gene, cloned from a cDNA library of N. fowleri by …
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Characterization of an nf-actin gene in the pathogenic Naegleria fowleri
Naegleria fowleri, a pathogenic free-living amoeba has been isolated from samples obtatined from soil,polluted water and chlorinated swimming pool waster and existed as a virulent pathogen which causes fatal primary amoebic meningoencephalitis (PAM) in experimental animal or humans. The …
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Cytopathic Effects of a Pathogenic Naegleria fowleri and an Anti-Nfa1 Antibody on Rat Microglial Cells
Naegleria fowleri, a free-living amoeba, causes fatal primary amoebic meningoencephalitis (PAME) in experimental animals and humans. On the pathogenic mechanisms of N. fowleri concerned with host tissue invasion, the adherence of amoeba to host cells is most important. The nfa1 gene (360 bp) was …
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Role of the Nfa1 Protein in Pathogenic Naegleria fowleri Co-cultured with Target Cells
Naegleria fowleri, a free-living amoeba, exists as a virulent pathogen which causes fatal primary amoebic meningoencephalitis (PAME) in experimental animal and humans. Using infected and immune mouse sera, we previously cloned an antigenic gene (called nfa1) from a cDNA library of N. fowleri by …
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PROTEOMIC ANALYSIS OF TWO DIFFERENT STATES OF NAEGLERIA FOWLERI
Naegleria fowleri are free-living ameboflagellates found in soil and freshwater habitats throughout the world that cause a fatal disease in humans called Primary Amoebic Meningoencephalitis (PAM). Mechanisms of host resistance or susceptibility to infection have not been fully elucidated, and …
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Inflammasome activation in THP-1 target cells triggered by pathogenic Naegleria fowleri
Naegleria fowleri, also known as the brain-eating amoeba, causes acute primary amoebic meningoencephalitis. During swimming and other recreational water activities, N. fowleri trophozoites penetrate the nasal mucosa and invade the olfactory bulbs, resulting in intense inflammatory reactions in the …
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Cell death and Pro-inflammatory Cytokine Release of Rat Microglial Cells by Naegleria fowleri
Naegleria fowleri, a free-living amoeba, causes fatal primary amoebic meningoencephalitis in humans and experimental animals. In previous study, N. fowleri trophozoites showed the highly cytopathic activity and cytotoxicity against rat microglial cells by the morphological observation and 51Cr …
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The effect of nfa1 accination against Naeglearia fowleri infection
The pathogenic free-living amoeba, Naegleria fowleri, causes fatal primary amoebic meningoencephalitis in experimental animals and in humans. The nfa1 gene that is cloned from N. fowleri is located on pseudopodia, especially amoebic food-cups and plays an important role in the pathogenesis of N. …
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
Naegleria fowleri, a free-living amoeba that is found in diverse environmental habitats, can cause an acute fulminating hemorrhagic meningoencephalitis, called primary amoebic meningoencephalitis (PAM) in experimental animals and in humans. Pathogenicity of N. fowleri may be induced by …
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Production and Characterization of Monoclonal Antibodies against a Recombinant Nfa1 Protein Cloned from Pathogenic Naegleria fowleri
… studies of pathogenic Naegleria fowleri, monoclonal antibodies against a recombinant His-tag fusion Nfa1 protein cloned from pathogenic N. fowleri were produced, and its characterization was elucidated. In addition, to observe the usage in immunological studies, the localization …
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Protective Immunity in Mice Immunized with the Nfa1 Protein for Pathogenic Naegleria fowleri Infection
Pathogenic Naegleria fowleri causes a fatal disease, called as primary amoebic menigoencephalitis, in humans and experimental animals. In the present study, to examine the protective immunity of the Nfa1 protein for N. fowleri infection in a mouse model, BALB/c mice were immunized with the Nfa1 …
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Opportunistic Pathogens and the Brain-eating Amoeba, Naegleria fowleri in Reclaimed Water, Municipal Drinking Water, and Private Well Water
… especially for the emerging OP, Naegleria fowleri (i.e. brain-eating amoeba). Three phases of investigation were carried out to identify factors that facilitate the growth of OPs in main distribution and premise plumbing systems, with particular attention on reclaimed water systems, aging …
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Expression of inflammasome-related molecules from U87MG cells cocultured with Naegleria fowleri in the non-contact system
Naegleria fowleri, a free living amoeba widespread in moist soil, water and sediment, exist as a virulent pathogen causing fetal primary amoebic meningoencephalitis (PAM) in experimental animals and in humam. Inflammasomes are large intracellular multiprotein complexes that play a central role in …
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The Characterization of Circular Extrachromosomal rDNA Elements in Naegleria SPP
… non-pathogenic except for Naegleria fowleri, which is the only species of Naegleria to cause disease in humans. Organisms of the Naegleria genus are further characterized by a circular extrachromosomal rDNA element (CERE) that is localized to the nucleolus. The CERE is unique because …
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An assessment of health hazards associated with the use of water mist systems as a cooling intervention in Australia
… Mycobacterium avium, Acanthamoeba and Naegleria fowleri is emerging as a challenge for public health and water quality management. Contrary to other premise plumbing features like showers and domestic taps that have been implicated in various waterborne infections, the health risks associated …
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Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri
파울러자유아메바(Naegleria fowleri)는 원발성 아메바성 수막뇌염(primary amoebic meningoencephalitis; PAM)을 일으키는 병원체이다. 파울러자유아메바의 사람이나 실험 동물에 감염은 아메바가 오염된 물에서 물놀이 혹은 수중활동을 할 때 비강내로 아메바 영양형이 유입될 때 일어난다. 파울러자유아메바의 병인기전으로는 숙주세포와 접촉하여 사멸에 이르게 하는 접촉성 병인기작과 여러가지 단백분해효소를 분비하여 숙주세포에 영향을 주는 비접촉성 병인기작으로 알려져 있다. 파울러자유아메바의 시스테인 …
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Characterization of opportunistic Pathogens in Drinking Water Supplied by Private Wells
… associated with disease), and Naegleria fowleri in private wells with recent history of flooding (i.e., Hurricanes Harvey and Irma in 2017, or the Great Louisiana Floods in 2016, extending to Texas, Florida, and Louisiana). All samples in both studies were analyzed for total bacterial 16S …