Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"myxoma virus"”.
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Functional analysis and development of novel marked vaccines against Myxoma virus
… para lo cual se postuló la construcción de un virus mixoma recombinante marcado por deleción de un gen antigénico, además de una prueba serológica diferencial capaz de distinguir animales infectados de los vacunados. Tras una exhaustiva revisión bibliográfica se seleccionaron 6 proteínas …
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Enhancing efficacy of oncolytic myxoma virus and adoptive T cell therapy against tumors
… viral therapy, the use of cancer-specific viruses to target and kill cancer cells. Combining immunotherapies and viral therapies has shown synergistic effect in the past. Most of our work focused on myxoma virus, a rabbit poxvirus, which can efficiently infect various types of mouse and …
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Myxoma Virus Therapy of Malignant Gliomas in Murine Syngeneic Models: Translating Barriers to Therapy
… into non-traditional therapies. Oncolytic virus therapy entails the use of replication competent viruses that selectively infect, replicate and kill cancer cells. This multi-modal therapy can function to directly kill cancer cells, stimulate anti-tumour immune responses, and be engineered …
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Molecular Signatures of Adaptation: MHC Evolution and Natural Selection in European Rabbits
… evolutionary changes in natural populations. The myxomatosis pandemic in European rabbits (Oryctolagus cuniculus) provides an unprecedented opportunity to examine MHC-I evolution under intense viral selection. Following the release of myxoma virus as a biological control in 1950s in Australia, …
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Immunotherapy for murine glioma
… is a novel approach to cancer treatment. Viruses can directly kill cancer cells, provide antigens to dendritic cells to stimulate a T cell response, and make cancer cells express genes of immune-enhancing cytokines locally within the tumor microenvironment. We hypothesized that the …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… tract with low-risk and high-risk human papillomaviruses is the cause of recurrent respiratory papillomatosis and a subset of head and neck cancers, respectively. E6 protein is considered one of the oncoproteins encoded by high-risk HPVs, due to its ability to degrade tumor suppressor p53, …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… tract with low-risk and high-risk human papillomaviruses is the cause of recurrent respiratory papillomatosis and a subset of head and neck cancers, respectively. E6 protein is considered one of the oncoproteins encoded by high-risk HPVs, due to its ability to degrade tumor suppressor p53, …
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Treatment of murine tumors with recombinant Myxoma viruses
Oncolytic viruses are designed to be novel cancer treatments that not only specifically target cancer cells, but can act as vectors to express proteins of interest within the tumor bed. Myxoma virus (MYXV), a rabbit-specific poxvirus, was evaluated as an oncolytic viral treatment for cancer in …
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Improvement of the Capripoxvirus, lumpy skin disease virus for use as a vaccine vector
… LSD. Live attenuated lumpy skin disease virus (LSDV) has been used as a vaccine against LSD. The most successful LSD vaccine is the Neethling vaccine strain (nLSDV) from South Africa. There are however, reports of nLSDV being too attenuated or too virulent in different breeds of cattle. A …
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Vaccine Development Strategies for Crimean-Congo Hemorrhagic Fever Virus and its Tick Vector
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus with an extensive geographic range and complex ecology. Ticks within the Hyalomma genera are the primary vector and reservoir of the virus and maintain the virus through a cryptic tick-vertebrate-tick cycle in nature. However, …
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The Major Histocompatibility Complex in Rabbits
… as evidenced by the coevolution of the myxoma virus (MYXV) and the European rabbit (Oryctolagus cuniculus). The European rabbit, originating from the Iberian Peninsula, has been introduced worldwide, often becoming a pest. MYXV causes myxomatosis, a lethal disease for European rabbits, …