Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"myostatin"”.
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Gene expression profiling of myostatin null mice
… industry and for biomedical research. Altering myostatin function and administration of β-adrenergic agonists, such as clenbuterol, enhances muscle growth. However, it is unclear whether the mechanisms of these effects converge in a single pathway. Previous work demonstrated that myostatin null …
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The role of myostatin during postnatal myogenesis and sarcopenia
Myostatin, a TGF-β superfamily member, is a key negative regulator of embryonic and postnatal muscle growth. In order to further elucidate the role of myostatin during postnatal growth, several lines of investigation were undertaken in mice. Analysis of myostatin downstream target genes identified …
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Altering Muscle Hypertrophy and Fat Accumulation in Myostatin Null Mice
Myostatin is a negative regulator of muscle growth. Loss of myostatin function results in a dramatic phenotype in several species including cattle, mice, dogs and humans. Myostatin mutants exhibit wide-spread hypermuscularity and decreased fat accumulation. Though the phenotype of myostatin mutant …
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The role of acute ambient hypoxia in the regulation of myostatin
… Chronic hypoxia also presents with elevated myostatin peptide, a negative regulator of muscle size. This work induced acute hypoxia in healthy individuals; hypothesizing hypoxia would increase myostatin expression in both muscle and plasma in a concentration- and time-dependent manner. …
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Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV)
Myostatin (Mstn), a member of the transforming growth factor-β super family, is a potent negative regulator of skeletal muscle mass. Studies delineating the function of Mstn have identified multiple signal transduction pathways that convey the Mstn signal. Mstn has been shown to influence canonical …
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The structure of human pro-myostatin and molecular basis of latency
Myostatin is a secreted growth factor of the transforming growth-factor $\beta$ (TGF$\beta$) superfamily, and a powerful negative regulator of muscle mass in vertebrates. As such, there is considerable interest in developing pharmacological agents which inhibit myostatin signalling in order to …
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Regulation of skeletal muscle growth and gene expression by insulin-like growth factors and myostatin
… of other growth factors such as IGF1 and myostatin. The final objective was to determine how IGF1 and IGF2 cooperate with myostatin to regulate skeletal muscle growth. Therefore, we quantified IGF family member expression in myostatin null (MN) and wild type mice. Skeletal muscle IGF1 …
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Functional profiles of growth-related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle
… chain reaction (RT-PCR) was performed to measure myostatin, follistatin, activin-B gene expressions during chicken embryonic development. Strong myostatin expression was found in the early chicken embryos (E 0, E 1) and the developmental expression pattern of myostatin mRNA coincided with the …
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Comparative analysis of the porcine IGF2-G3072A mutation and reduced myostatin function on meat quality and unexplained mortality in pigs
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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The role of growth factors in the regeneration of skeletal muscle
The overall aim of this thesis was to examine myostatin and components of the insulin-like growth factor (IGF) axis during regeneration, to determine whether these factors were temporally regulated during regeneration, whether the absence or presence of growth hormone (GH) affected their levels, …
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Characterization of mice with mutations disrupting binding of a transcriptional repressor of insulin-like growth factor 2 and loss-of-function mutation of myostatin
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Multiple trait analysis for genetic mapping of quantitative trait loci for carcass and beef quality
… a major QTL on BTA2 close to the map position of myostatin gene, affecting yield, carcass fatness and beef quality traits. In the second phase, the pleiotropic effects of a myostatin functional SNP on beef traits were studied. There was no association between this myostatin variant and birth …
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Effects of 28 days of protein and amino acid supplementation and ankle immobilization on gastrocnemius muscle mass and strength and atrophy- and apoptosis-related gene expression in males.
… E2, E3, atrogin-1, MuRF1, calpain 1, calpain 2, myostatin, TNF-α, and NF-κB. Results: Lower-leg girth decreased over time (p = 0.020), and increased the expression of several genetic variables, but there were no significant changes in the body composition or strength variables (p > 0.05). All …
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The effects of maternal and postnatal infections with porcine reproductive and respiratory virus on muscle growth and development in piglets
… chain (MHC) 2b (P=0.02), MHC2x (P=0.01), and myostatin (P=0.01) expression decreased in P piglets compared with C piglets. However, at d28, there were no differences in MHC expression. A shift towards more oxidative fiber types also occurred in the PM at d0, as MHC1 expression was increased …
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The Influence of Growth Stage on Carcass Composition and Factors Associated with Marbling Development in Beef Cattle
… γ (PPARγ), CCAAT/enhancer binding protein β, and myostatin. Carcass data were recorded and LM samples were collected and aged 2, 7, 14, and 21 d postmortem for Warner-Bratzler shear force (WBSF) determination. Carcass composition was estimated by dissection of the 9- 10-11 rib section and …
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Effects of lower- and higher- volume resistance exercise on serum testosterone and skeletal muscle androgen receptor content in men : subsequent effects on the mRNA expression of insulin- like growth factor peptide and myostatin in skeletal muscle.
… the expression of insulin–like growth factor and myostatin which are key regulators of muscle protein balance. Higher-intensity resistance exercise in non-resistance-trained participants is known to increase endogenous serum testosterone levels. However, using resistance-trained participants the …
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Growth of Pigs With Viral and Bacterial Pneumonia
… PA, and positively correlated with MSTN mRNA. Myostatin mRNA was positively correlated with WG and PA. Thus, the magnitude of increases in inflammatory cytokines and MSTN following a disease challenge may be predictive of the decreases that can be expected in PA and growth. Collectively, these …
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Growth response to resistance exercise : influence of exercise device
… 2.0 fold) and decreased (P < 0.05) expression of Myostatin (1.4 vs. 1.5 fold) to a similar degree on both exercise devices. There was no change in the expression of Atrogin-1, MuRF-1 or MRF4 following RE on either device. The only device mediated difference in the expression of the selected genes …
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Signal Transduction in Skeletal Muscle Mediating Responses to Phenotype Altering Signals
… skeletal muscle phenotype and size changes. Myostatin, recently identified as a negative regulator of muscle mass was exposed at 10 ng ml 4 to C2C12 cells, and using cDNA genome-wide profiling, was shown to act as a transcriptional suppressor. Furthermore, in these cells myostatin …
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Osteocyte Activity and Skeletal Muscle Relative Gene Expression Profiling After Short-term Muscle Paralysis
… showed increased relative gene expression of myostatin in BTX left versus BTX right (injected) and both CTRL limbs, indicating a potential systemic effect of Botox and/or disuse.</p>
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