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Showing 1 to 6 of 6 for “"myosin-binding-protein c"”.
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Haploinsufficiency of Cardiac Myosin Binding Protein-C in the Development of Hypertrophic Cardiomyopathy
… and sarcomere disarray. Mutations in sarcomeric protein encoding genes have been established as causative for HCM.</p><p>The gene MYBPC3, encoding cardiac myosin binding protein-C (cMyBP-C), is the second most commonly mutated gene in HCM cases. As a majority of these mutations have been …
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Hypertrophic Cardiomyopathy: A Review of Clinical and Molecular Characteristics and Effects and A Clinical Case Study
… death in young athletes. Mutations of the myosin-binding protein C (cMyBP-C) have been targeted as one of the most prevalent causes of this disease, and the deactivating effects of such mutant forms on the quality control ubiquitin-proteasome system (UPS) contribute to cardiac dysfunction. …
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Multi-scale analysis of cardiac myoarchitecture
… associated with deletion of the gene for myosin binding protein C (cMyBP-C) in the mouse. Normal cardiac muscle fiber alignment within the ventricular wall was characterized by a series of helical tracts transitioning from a lefthanded orientation in the subepicardium to circumferential in …
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Thick filament regulation of myocardial contraction
… effects of sarcomere length and thick filament protein isoform expression on the contractile properties of single skinned cardiac myocytes. Myosin binding protein-C ablation (MyBP-C-\-) increases the rate of force development, loaded shortening velocity, and power output in mouse skinned cardiac …
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Proteomic analysis of diurnal variation in human skeletal muscle performance
… of human muscle based on its profile of myosin heavy chain isoforms is commonly used to help understand changes in muscle function. However, in many instances, measureable changes in force output or contractility occur in the absence of any change in myosin heavy chain profile. Therefore, …
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Modifikation des Hypertrophie-Phänotyps der Myosin-Bindungs-Protein-C defizienten Maus durch Muscle-LIM-Protein
Modifikation des Hypertrophie-Phänotyps der Myosin-Bindungs-Protein-C defizienten Maus durch Muscle-LIM-Protein Von einer Herzinsuffizienz sind etwa 3 % der Menschen in den alten Bundesländern betroffen. Ursächlich liegt oft eine genetische Veränderung in Funktionsproteinen vor, zu denen das …