Global ETD Search
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Showing 1 to 6 of 6 for “"myosin light chain phosphatase"”.
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MATHEMATICAL MODELLING OF CALCIUM DEPENDENT ACTIVE CONTRACTION IN A GASTROINTESTINAL SMOOTH MUSCLE CELL
… triggered by calcium dependent activation of Myosin Light Chain Kinase (MLCK) which is the primary mechanism has been described in terms of two interacting modules - the first module describing the activation of MLCK, and the second describing cross-bridge formation between actin and myosin. …
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Chemical Biology Tools for Biochemical and Functional Analysis of Myosin Phosphatase
… hypocontractility in AF to dysregulation of myosin light chain phosphatase (MLCP), a holoenzyme composed of a catalytic subunit (PP1cβ) and a regulatory subunit that targets the phosphatase to sarcomeric substrates. PPP1R12C is an atrial-enriched MLCP regulatory subunit that directs PP1cβ to …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… extracellular calcium concentrations. Non-muscle myosin is contributing to the force development in the newborn but is not the cause for the increased calcium sensitivity. The increased calcium sensitivity is due to a lower phosphatase activity and a lower expression of the myosin light chain …
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Stretch-Dependant Tonic Force Maintenance in Rabbit Epigastric Artery
… of hypertension. Upon muscle stimulation, Ca2+, myosin light chain (MLC) phosphorylation, crossbridge cycling rates and force increase to high levels, but with time, force is maintained while all other parameters of muscle activation fall to low levels. Thus, contraction is divided temporally …
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Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
… insult alone. Long (210 kDa) smooth muscle myosin light chain kinase (MLCK), an enzyme important for epithelial tight junction maintenance, has been implicated in barrier alterations after burn injury or ethanol exposure alone. With this knowledge, <underline>we hypothesize that the …
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Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… contraction is mainly achieved by Ca2+ dependent myosin light chain kinase activation, contribution of Ca2+ sensitization mechanisms by myosin light chain phosphatase (MLCP) inhibition is being increasingly recognized as these mechanisms have been shown to be altered in many pathological states of …