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Showing 1 to 20 of 44 for “"myosin II"”.

  1. The rule of Myosin II and Rap2 in synaptic structure and function

    Ryu, Jubin WonsunMassachusetts Institute of Technology2008

    … processes. Among these are the molecular motor myosin II and the Ras family GTPase Rap2. Myosin II can move and contract actin filaments in non-neuronal cells, and it represents a novel way to alter spine structure, which is classically thought to occur through actin polymerization and …

    mit Repository record

  2. Röntgenstrukturanalyse der GTPase-Domäne von Dynamin 1 und der Motordomäne von Myosin II

    Reubold, ThomasUniversität Heidelberg

    … aus Rattus norvegicus sowie der Motordomäne von Myosin II aus Dictyostelium discoideum in atomarem Detail aufgeklärt werden. Die vorgelegte Kristallstruktur der nukleotidfreien GTPase-Domäne von Dynamin 1 zeigt, daß die GTPase-Domäne in Säugerdynamin sehr ähnlich gefaltet ist wie in Dynamin A aus …

    heid-diss Repository record

  3. Structural mechanism of the recovery-stroke in Myosin II molecular motor at atomic detail

    Koppole, Sampath KumarUniversität Heidelberg

    Das molekulare Motorprotein Myosin wandelt chemische Energie aus der ATP Hydolyse in mechanische Arbeit um, die dazu genutzt wird um Myosin- und Aktin-Filamente gegeneinander zu verschieben und so z.B. die Muskelkontraktion zu ermoeglichen. Der Mechanismus dieser chemisch-mechanischen Kopplung, der …

    heid-diss Repository record

  4. Distinct Functions and Regulation of Nonmuscle Myosin II Isoforms a and B in Cell Motility

    Sandquist, Joshua C2008

    … dynamic and precise rearrangement of the actin-myosin cytoskeleton. As a critical component of the migration machinery, the molecular motor protein nonmuscle myosin II (myosin II) has long been a subject of scientific inquiry. It is now generally accepted that the contractile forces generated by …

    duke Repository record

  5. Synthesis and Structure-Activity Relationship Studies of 3-(N-Butylethanimidoyl)-4-hydroxy-2H-chromen-2-one (BHC) Analogues for Myosin II Inhibition

    Brawley, Jhonnathan2022

    … cause of myopathies and muscle movement, myosin II, can be targeted. There are many small molecules that are currently being studied to inhibit the various isoforms of muscle myosin II including blebbistatin. Recently a coumarin based Schiff base, …

    unr Repository record

  6. Dynamins and myosin-II regulate the distinct modes of synaptic vesicle exocytosis in mature cerebrocortical nerve terminals and this involves calcium dependent phosphorylations.

    Bhuva, DilipUniversity of Central Lancashire2015

    … blockade of the ATPase activity of non-muscle myosin-II suggest that myosin-II may also be able to regulate the fusion pore, independent of dynamin-I, when a different stimulus (HK5C) is employed. The three stimuli employed here produced distinct kinetics for changes in [Ca2+]i and suggest that …

    cent-lancashire Repository record

  7. Adherens Junctions and The Actomyosin Network Regulate Organ Growth By Modulating Hippo Pathway Activity In Drosophila

    Yang, Chih-Chao2013

    … Hippo pathway activity.</p> <p>Non-muscle myosin II is an actomyosin component that interacts with the actin. Non-muscle myosin II also interacts with lgl, though the function of this interaction is not clear. Our lab demonstrated that modulating F-actin regulates Hippo pathway activity, …

    uthsc Repository record

  8. Anillin Stabilizes Membrane-cytoskeleton Interactions During Drosophila Male Germ Cell Cytokinesis

    Goldbach, Philip Daniel2011

    … Anillin binds filamentous F-actin, non-muscle myosin II and septins, and in cell culture models has been shown to restrict actomyosin contractility to the cleavage furrow. Whether anillin also serves this function during the incomplete cytokinesis that occurs in developing germ cells has …

    toronto-retro Repository record

  9. Spatiotemporal organization, regulation and function of traction during neutrophil chemotaxis

    Shin, Myung EunUniversity of Illinois at Urbana-Champaign2012

    … tractions depend upon the activity of non-muscle myosin IIA. Specifically, traction development at the leading edge requires myosin light chain kinase (MLCK)-mediated myosin II contractility and is necessary for α5β1-integrin activation and leading edge adhesion. Localized myosin II activation …

    uiuc Repository record

  10. Mechanisms of Asymmetric Protein Localization in Drosophila Embryonic Neural Stem Cells

    Peng, Chian-YuUniversity of Illinois at Urbana-Champaign2015

    … suggest Lgl mediated basal targeting occur via a myosin-based transport mechanism, which is supported by genetic studies that show loss of Myosin II suppresses Lgl phenotype in neuroblasts. Taken together, we conclude that Lgl may function to suppress Myosin II activity and allow/promote positive …

    uiuc Repository record

  11. Reexamining actin polymerization in maintaining cadherin mediated cell-cell adhesion

    Li, XiaoheUniversity of Illinois at Urbana-Champaign2021

    … actin polymerization builds contractile actomyosin networks which pull on cadherins and strengthen the mechanosensitive bonds (the contractility model) or the fence around clusters of cadherins which mediate stronger adhesion than single cadherins (the clustering model). Actin polymerization …

    uiuc Repository record

  12. The Molecular Basis of Tissue Elasticity and Force Balance During Drosophila Gastrulation

    Goldner, Amanda Nicole2024

    … source of active forces in F-actin networks: myosin II. My design allows us to specifically degrade Drosophila myosin II in under 1hr in vivo. This will allow us to precisely quantify the contribution of myosin II to not only tissue elasticity, but any other feature or developmental process of …

    utswmed Repository record

  13. The Role of UNC-45 in Heart Development and Human Breast Cancer

    Chen, DaisiThe University of Texas Medical Branch at Galveston2016

    … as a molecular chaperone of body-wall muscle myosins. In human and other vertebrates, two UNC-45 genes code two UNC-45 protein isoforms: UNC-45A/a and UNC-45B/b. UNC-45A/a is expressed in all cell types, whereas UNC-45B/b only exists in heart and skeletal muscles. This thesis investigated the …

    utmb Repository record

  14. Phosphorylation sites on specific neuronal proteins can control the mode of synaptic vesicle exocytosis and thereby regulate synaptic transmission

    Singh, DeebaUniversity of Central Lancashire2017

    … together with 5 mM Ca2+. In this model employed, myosin-II and dynamins can regulate the closure of the fusion pore of the readily releasable pool (RRP) of SVs during KR but are independent of each other’s actions. In biochemical assays, synaptosomes were maximally labelled with FM2-10 dye such …

    cent-lancashire Repository record

  15. Probing the regulatory mechanisms of the actomyosin system in motile cells

    Barbosa Pfannes, Eva KatharinaUniversität Potsdam

    … responses, and development of tissues. Actin and myosin are essential players in this process that can be subdivided into protrusion, adhesion, and traction. Protrusion is the forward movement of the membrane at the leading edge of the cell. Adhesion is required to enable movement along a …

    potsdam-diss Repository record

  16. The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells

    Hoelzle, Matthew K2011

    … Subsequently, bridge bundles recruit nonmuscle myosin II and mature into stress fibers. Myosin II activity was important for bridge formation and accumulation of VE-cadherin in nascent adherens junctions. Our data reveal a mechanism of cell-cell junction formation in endothelial cells utilizing …

    penn Repository record

  17. Photonic Tweezers for Optical Manipulation of Cells and Tissues

    Ferro, ValentinaUniversity of Dundee2019

    … area seems to be correlated with the presence of myosin II cables.<br/><br/>I optically manipulated cell-cell junctions in chick embryos while recording their deformation. I measured the difference response of junctions studied under different conditions. The results support the idea that …

    dundee Repository record

  18. Mechanotransduction at the nuclear envelope: the role of forces in facilitating embryonic stem cell fate decisions

    Wylde, George WilliamUniversity of Cambridge2017

    … – notably the molecular motor non-muscle myosin II - and key structural and chromatin binding proteins in the nuclear envelope, notably, the lamins (LMNA), Lamin B receptor (LBR) and components of the LINC complex (nesprins/KASH). The structural proteins in the nuclear envelope regulate …

    cambridge Repository record

  19. Effects of cross-link and myosin motor concentrations on active muscle gel contraction time and extent

    Babcock, Joseph M. (Joseph Michel)Massachusetts Institute of Technology2017

    … the functionality of the cytoskeleton. Utilizing myosin II motor proteins to initiate contraction events in actin networks, active muscle gels have the unique potential of acting as microscopic actuators. Two challenges currently faced by active muscle gels are their slow contraction time and weak …

    mit Repository record

  20. Biochemical differences in the modes of synaptic vesicle release between control and streptozotocin-induced diabetic rats and possible relationship to changes in behaviour

    Patel, Mansi HUniversity of Central Lancashire2011

    … Blockade of calcium/calmodulin dependent kinase II (CaMKII) was found to inhibit completely the release of reserve pool (RP) of vesicles, with no effect on readily releasable pool (RRP) of vesicles in control terminals. However, by studying the release of just the RRP of SV it was discovered …

    cent-lancashire Repository record

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