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Showing 1 to 20 of 36 for “"myometrium"”.
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Ultrastructural Changes in the Uterine Myometrium of Ovariectomized Rabbits During Estrogen Administration
Made available in DSpace on 2014-12-05T22:14:45Z (GMT). No. of bitstreams: 1 6305097.pdf: 5039165 bytes, checksum: 317c2213148a9819d5daf66013336cde (MD5) Previous issue date: 1963
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Identification, Characterization and Function of Voltage-Gated and Two-Pore-Domain Potassium Channels in the Mouse Myometrium.
… in the regulation of Kv channels and currents in myometrium from any species.|I have observed a potent contractile effect of the Kv channel blocker 4- aminopyridine (4-AP) in nonpregnant mouse myometrium, a response which is not mediated by nerves, the endometrium, or the large-conductance, …
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TREK-1 confers differential effects on contractile dynamics in myometrium and the oviduct, indicating a unique role in endometriosis and labor
… been found to increase oxytocin receptors in the myometrium, leading to an increase in contractility. It has been established that TREK-1, a potassium channel, plays a major role in quiescing the myometrium, which is essential for maintaining pregnancy. However, the effects of IL-6 and the role of …
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Intimations on the Development of Effective Treatment for the Prevention of Preterm Birth: β3 Adrenergic Receptor Signaling in the Human Myometrium
… present in various tissues, including the human myometrium. Using contractile studies, stimulation of the β3AR has been shown to mediate relaxation. Although some pathways have been described, the mechanism(s) underlying β3AR-mediated relaxation in the myometrium are incompletely known. In other …
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mRNA-Expression des CRH-Systems in menschlichen schwangerschaftsspezifischen Geweben
… untersucht. Dazu wurde eine Gewebebank mit Myometrium, Plazenta, Dezidua, Chorion und Amnion von ca. 100 Patientinnen aufgebaut. <br>Zunächst wurden die RT-PCR-Methoden für alle o.g. Komponenten des CRH-Systems etabliert. Untersuchte Einflussgrößen waren dabei die RNA-Qualität, die …
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The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract.
… was carried out in endometrium (n=9) and myometrium (n=15- 16) donated by non-pregnant women and lower segment myometrium obtained from pregnant women (before (n=14) and after labour onset (n=7)) by liquid chromatography coupled with electrospray ionisation mass spectrometry (LC/ESIMS/ …
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The effects of diethylstilbestrol on myometrial contractility in mice
… been shown to cause structural changes to the myometrium of mice and humans, as well as gross anatomical malformations, adenocarcinoma, and infertility in both male and female offspring. My study focused on DES-induced structural changes of the myometrium in mice and related them to uterine …
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Antagonistic Roles of miR-199a-3p/miR-214 and the miR-200 Family in the Regulation of Uterine Contractility During Pregnancy and Labor
… miR-200a, to enhance local metabolism of P4 in myometrium and, thus, decrease PR function during the progression towards labor (Williams et. al., 2012a). This occurs via miR-200a repression of signal transducer and activator of transcription (STAT)5b, a transcriptional repressor of the …
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Characterization of NADPH Oxidases in Uterine Smooth Muscle during Pregnancy
During gestation, the uterine smooth muscle, or myometrium, transforms from a quiescent tissue to a contractile muscle required for parturition. Immune system activation is a crucial precursor to labour during which the myometrium is infiltrated by immune cells. Immune and myocyte activation rely …
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The splice variants of TREK-1 act as dominant-negative suppressors of human uterine relaxation: Implications for preterm labor
Human myometrium plays a pivotal role during pregnancy remaining quiescent during fetal development while eventually producing the forceful contractions necessary for parturition. The complex mechanism of maintaining uterine quiescence and triggering contraction is unclear. Spontaneous or …
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Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology
… substitutions in the codon GGT. We show that myometrium is persistently exposed to peroxynitrite, as is endometrium. Oxidative guanine damage, promoted by peroxynitrite exposure, explains the prevalence of guanine mutations observed in leiomyomas. Benign human endometrial tissue and normal …
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Phosphorus-31 nuclear magnetic resonance spectroscopy of human uterus and placenta
… on isolated samples of placenta and uterus (myometrium and endometrium). Our studies have revealed interesting correlations between spectral characteristics and the type of tissue studied, normal and abnormal.
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Development, Validation, and Application of Electromyometrial Imaging (EMMI) to Noninvasively Image Uterine Contractions
… of first stage labor, we find that partial myometrium is activated during the uterine contractions measured at the early stage of the labor. The percentage of the activated myometrium contributing to the uterine contraction measured by TOCO or IUPC clinically increases as the labor …
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
… estrogen-responsive gene expression in the myometrium and promote the development of uterine leiomyoma. We proposed the mechanism that is responsible for the developmental reprogramming of gene expression was through estrogen (E2)/ xenoestrogen inducedrapid ER signaling, which modifies the …
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Effect of Long-term Hypoxia on Myometrial Contractility in the Pregnant Sheep
… and cGMP-depended protein kinase (PKG) activity. Myometrium was collected from near-term pregnant sheep exposed to high altitude-associated LTH and from normoxic pregnant controls. After pretreatment with 10<sup>-8</sup> M oxytocin (OT), circular and longitudinal myometrial strips were treated …
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Induction of the oxytocin receptor and its role in luteolysis in sheep
… density of oxytocin receptors in endometrium and myometrium when compared to the vehicle-treated groups. In the endometrium, withdrawal of progesterone after day 9 resulted in an increase in the concentration of oxytocin receptor on day 13 (P $<$ 0.01) and estradiol enhanced the effects of …
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Role of Sox9 In Uterine Gland Development and Disease Initiation
… by a mesenchymal layer, the stroma and myometrium. Interestingly, in most mammals the GE forms after birth and it only becomes fully differentiated as the female reaches sexual maturity. Uterine glands (UG) are made up of GE and are present in all mammals. They secrete nutrients, …
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
… smooth muscle tissue layer of the uterus, the myometrium. UL are the most common female reproductive tract tumors, with lifetime occurrence in up to 77% of all women. A third of women with UL require treatment for clinically significant symptoms of menorrhagia, severe pain, anemia and fertility …
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