Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"myogenic tone"”.
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Postnatal Maturation Modulates Cerebrovascular Myogenic Tone
… stores to develop and maintain pressure-evoked myogenic tone in rat cerebral blood vessels. To test this hypothesis, pressure-induced myogenic tone and changes in artery wall ([Ca2+]i) were measured simultaneously in isolated endothelium denuded, fura-2 loaded middle cerebral arteries (MCA) from …
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Investigation of Hydrogen Peroxide/Reactive Oxygen Species-Related Signaling on Vasoactive Responses in Myogenic Resistance Arteries
… to endothelium-derived hyperpolarization in myogenically-active resistance arteries, and its contribution to the responses evoked by established vasoactive agents. In particular, I hypothesize that H2O2 and/or ROS serve as physiologic, vasoactive agents in myogenically-active resistance …
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The Role of VEGF and Smooth Muscle Phenotype in Hypoxic Remodeling of Ovine Carotid and Cerebral Arteries
… of contractile proteins as well as changes in myogenic tone. All of these factors culminate in changes in status or behavior of the vascular smooth muscle within the vessel wall, likely secondary to changes in smooth muscle phenotype. This investigation examines the hypothesis that hypoxia …
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Mitochondrial Regulation of Arterial Contractility
… leading to an increase in both pressure (myogenic tone)– and depolarization–induced vasoconstriction. Baseline Ca<sub>V</sub>1.2 expression and the ET–1–induced elevation in Ca<sub>V</sub>1.2 expression were both reduced by IP<sub>3</sub>R inhibition, mitochondrial electron transport chain …
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Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes
… During hypertension, cerebral arteries have high myogenic tone and are less responsive to vasodilators, including nitric oxide (NO). The regulation of arterial contractility by BK channels is altered during hypertension, although mechanisms involved are also unclear. </p> <p><strong>Objective: …
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Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2
… novel role of microRNAs in the pressure-induced myogenic response. We demonstrated that global deletion of smooth muscle-specific microRNAs causes a loss of pressure-induced contraction and that this likely involves diminished calcium influx due to reduced stretch-induced activation of the …