Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 102 for “"myogenesis"”.
-
Membrane-cytoskeleton associations during myogenesis
… cell surface dynamics during skeletal myogenesis. As a result of such cytoskeletal constraints on the topography and mobility of integral membrane proteins, the sarcolemma of developing muscle may become partitioned into specific functional membrane domains. Several inconsistencies with …
-
SUFU in SHH signalling mediated myogenesis
Myogenesis is defined as the formation of skeletal muscle tissue during embryonic development and involves a multitude of cellular signalling pathways. Among these include the Sonic hedgehog (Shh) signalling pathway which must be deactivated for differentiation into muscle cells to occur. However, …
-
ROLE OF G9A IN SKELETAL MYOGENESIS
Sarcomeres are the basic contractile unit of striated muscle and is essential for muscle contractile function such that mutations in sarcomeric proteins underlie skeletal muscle disease and dysfunction. Here, we provide evidence that the lysine methyltransferase G9a represses expression of several …
-
Exploring the impact of osteoporosis on myogenesis
… factors on skeletal muscle cell differentiation (myogenesis) in the presence of osteoporosis. A series of studies have been completed in mouse models, and our concomitant goal was to expand these studies into humans. Serum used was collected from research subjects in an ongoing case-control study …
-
Elucidation of the Cardiac Myogenesis Regulatory Network
… processes conducted within one species.Cardiac myogenesis, the development of heart muscle cells, is the earliest heart development process and is required for the formation of all adult heart structures. Key signaling pathways, and their precise timing and targets, have only recently begun to …
-
Maternal feed intake and myogenesis in sheep
"This thesis describes two models developed to investigate the effect of maternal feed intake on muscle cellularity and myogenic gene expression of fetal sheep." --p. vi.
-
The α7β1 integrin accelerates exercise-induced myogenesis
… also results in enhanced and/or accelerated myogenesis following a single bout of eccentric exercise. METHODS: 5-wk old, female wild type (WT) and α7 integrin transgenic (α7Tg) mice completed a single bout of downhill running exercise (-20o, 17 m/min, 60 min) and gastrocnemius-soleus …
-
Functional Genomics Characterization of Six4 During Skeletal Myogenesis
… of the MRF MyoD, a central regulator of skeletal myogenesis, to convert a non-muscle cell model into the myogenic lineage was impaired with attenuated Six4 expression. I employed genome-wide approaches by combining ChIP-sequencing with gene expression profiling and identified a set of muscle genes …
-
Angiogenesis and Myogenesis in a Chronic Ischemic Heart.
<p>Miniswine underwent procedures to evaluate treating chronic ischemia with the implantation of autologous satellite cells and laser transmyocardial revascularization (TMR). The objective was to combine two therapies to restore cardiac function. This experiment involved three surgical procedures: …
-
Muscle-derived cytokines: novel regulators of skeletal myogenesis
… the roles of these muscle-derived cytokines in myogenesis, which is described in chapter II of this thesis. After screening 134 cytokine genes, we were able to categorize the resulting 29 positive hits into four functional groups (Table II.3). Class I and II cytokines represent potential …
-
The role of myostatin during postnatal myogenesis and sarcopenia
… cells to activate and a subsequent decline in myogenesis. Myostatin is a known inhibitor of postnatal satellite cell activation and muscle regeneration, thus muscle mass and regeneration, and satellite cell behaviour were examined in young and aged myostatin-null mice. Myostatin-null mice had …
-
Role of NPHS Gene in Mammalian Myogenesis and Rhabdomyosarcoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
The Role of Twist2 in Physiologic and Pathologic Myogenesis
The file named "LI-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.
-
Regulation of skeletal myogenesis by the mTOR signaling network
… myofibers. During embryonic skeletal myogenesis, cells in somites commit to myogenic lineage and differentiate into myoblasts, which then fuse to form multinucleated myofibers. Post-natal growth, repair, and maintenance of skeletal muscle are dependent on muscle satellite cells, which …
-
Regulation Of Cyclic-amp-dependent Protein Kinases During Skeletal Myogenesis
… levels of cAMP-dependent protein kinases during myogenesis in L6 was studied, as these enzymes have been proposed to be involved in the control of this process. Measurement of the mRNA levels for the type I regulatory subunit (R{dollar}sb{lcub}rm I{rcub}{dollar}) of cAMP-dependent protein kinase, …
-
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
… of either receptor significantly inhibited C2C12 myogenesis. Our results indicated that EP1 signaling is involved in regulating myogenin expression, while activation of EP4 receptor is important for fusion. In addition, the effect of PGE₂ on myoblast proliferation was also determined. Although …
-
Developmental regulation of the alpha(7) integrin chain during myogenesis
… Its expression is developmental regulated during myogenesis. Not only is the expression of $\alpha$7 transcripts increased upon myogenic differentiation, differential splicing of transcripts is also observed at that time. This differential splicing of $\alpha$7 transcripts results in three …
-
TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA
… an important function of TBX2 in the early myogenesis. Using molecular and cellular biology approaches we showed that TBX2 forms complex with myogenin and MyoD, and then recruits HDAC1 to muscle-specific promoters to repress the myogenin and MyoD dependent differentiation of myoblasts. In …
-
Investigating the molecular function of Akirin during skeletal myogenesis in Drosophila melanogaster
… new intermolecular partners for Akirin during myogenesis, we have shed new light on the molecular action of Akirin during embryonic development.</p>
Page 1 of 6