Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"myofilaments"”.
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Diaphragm dysfunction in COPD - Involvement of the myofilaments
Contains fulltext : 50641.pdf (Publisher’s version ) (Open Access)
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Diaphragm dysfunction in heart failure from myofilaments to pharmacological targets.
Contains fulltext : 74410.pdf (Publisher’s version ) (Open Access)
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k-Opioid Receptor Dependent Cardioprotection in the Rat
… leading to reduced ATP utilization by the <br />myofilaments.</p> <p> We tested this hypothesis by correlating post-ischemic contractile recovery and myofibrillar actomyosin Mg2+ATPase activity in isolated rat hearts. Pre-ischemic treatment with the k-opioid receptor agonist U50,488 (U50, 1 mM) …
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Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle
… or defective buffering of calcium by cardiac myofilaments. These studies illustrate the importance of physiologically relevant engineered tissue models to study inherited disease mechanisms with induced pluripotent stem cell technology.</p>
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Investigation of the mechanisms underlying the effects of hyperglycaemia on cardiac structural and electrical remodelling
… a disruption of the striated organization of the myofilaments. Hyperglycaemia increased the proportion of TUNEL-positive cells and the expression of the pro-apoptotic marker cytochrome c and decreased the anti-apoptotic protein Bcell lymphoma 2 but did not alter the mitochondrial staining with …
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Protein degradation in rat skeletal muscle : intracellular, non-lysosomal enzyme systems and their endocrine control
… less rapidly at low ionic strength (insoluble myofilaments) than at high salt concentrations (solubilized proteins). When the myofibrillar fraction was added to the particle-free cytosol prepared from the muscle extracts, proteins of the cytosol were also degraded, but the activity in this case …
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Effects of magnesium and calcium upon excitation-contraction coupling in the heart
Calcium (Ca2 ) availability to cardiac myofilaments is the primary factor determining the force of cardiac contraction. An intracellular organelle, the sarcoplasmic reticulum (SR), regulates the relaxation of the muscle as well as acting as a source of activating Ca2 during excitation-contraction …
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Cellular mechanism of contractile dysfunction in diabetes-induced cardiomyopathy
… increase amplitude of contraction and increase myofilaments sensitivity in the diabetic heart. The significant reduction in the rate of C2 uptake into the SR and Ca 2 efflux through Na/Ca 2texchanger result in longer decays of Ca 2 transient during diastole in the diabetic heart.