Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"myocardial ischemia"”.
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Pharmacological interventions against myocardial ischemia and reperfusion injury
… important factor to reduce the injury caused by myocardial ischaemia, reperfusion in itself can aggravate the damage to myocardial tissue, a phenomenon denoted myocardial reperfusion injury. Even though promising cardioprotective strategies have been presented in the pre-clinical setting, …
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Myocardial ischemia and reperfusion injury, clinical and experimental studies
Acute myocardial infarction is the consequence of an occluded nutrient coronary artery. Reperfusion reduces infarct size and enhances the rate of survival. But reperfusion may also, in itself, cause reversible injury, stunning and arrhythmias, as well as irreversible lethal reperfusion injury. The …
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Peripheral vascular manifestations of myocardial ischemia in the anesthetized dog
Thesis (M.S.)--Michigan State University. Dept. of Physiology, 1972
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
… as a mediator of cell fate in the setting of ischemia-reperfusion (IR) injury, and, ii) inhibition of DRP1 and mitochondrial fission provides cardioprotection against IR injury. However, the precise role of DRP1 translocation to mitochondria in the pathogenesis of myocardial …
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Proteomic Discovery of Functionally Important Pathways in Myocardial Ischemia-Reperfusion Injury
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
… raised in the clinical setting. Perioperative myocardial ischemia occurs more often than recognized. This may lead to myocardial infarction, increased morbidity, mortality, and health care costs. In the first study, myocardial metabolism was investigated before, during, and after 30 min of …
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Physiological Implications and Mechanisms of Estrogen Protection Associated With Myocardial Ischemia /Reperfusion Injury
… in cells, providing a better capacity to handle ischemia/reperfusion (I/R) injury (i.e., classical actions) and (2) activating a signaling network that confers reductions in cell death following I/R injury (i.e., non-classical actions). The effects of E2 on gene and protein expression were …
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The process of autophagy in an in vitro model of myocardial ischemia-reperfusion injury
… has been implicated in the pathogenesis of myocardial ischemia-reperfusion (I/R) injury; however, it is not clear whether autophagy is beneficial or detrimental to cell survival. We hypothesized that autophagy is beneficial to cardiomyocytes during I/R and that the paucity of ATP may limit …
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The Effects of Estrogen Receptor -Alpha, Estrogen and Phytoestrogen on Global Myocardial Ischemia -Reperfusion Injury
The effects of estrogen receptor-alpha on myocardial ischemia-reperfusion injury were investigated in male estrogen receptor-alpha knockout (ERKO) and wild-type control mice (Control). The effects of estrogen and phytoestrogen were investigated in 6 control mice (Control). The effects of estrogen …
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Development of rate related exercise-induced myocardial ischemia and risk of selected coronary disease endpoints
… A cardiac event was defined as having an myocardial infarction (MI), percutaneous translumial angioplasty (PTCA), coronary artery bypass grafting (CABG), and cardiac death. Comparisons were made just prior to each CE patients event. Statistical analyses were done on four exercise test …
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Interaction of exercise and simvastatin on myocardial ischemia-reperfusion (I/R) injury and post-ischemic cardiac function
… and exercise upon parameters of post-ischemic myocardial function and damage. Methods: Female Sprague-Dawley rats (6 months of age) were separated into 4 groups for a period of 4 weeks: Sedentary (S, n=10), sedentary plus 10 mg simvastatin (Zocor®)/kg body wt/ day (SD, n=9), exercise (R, n=9), …
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Measurement of the effectiveness of enhanced external counterpulsation on heart rate variability for patients with myocardial ischemia
… The study was conducted on patients who had myocardial ischemia and had been prescribed enhanced external counterpulsation treatment by the physician. One of the patients was a non-ischemic heart failure patient who had heart failure secondary to dilated cardiomyopathy. Myocardial ischemia is …
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Ventricular Depolarization in Ischemic Heart Disease.Value of Electrocardiography in Assessment of Severity and Extent of Acute Myocardial Ischemia.
… In patients with symptoms compatible with acute myocardial infarction (MI), early triage by ECG in the pre-hospital phase by ST-segment elevation myocardial infarction (STEMI) criteria is important for direct transport of these patients to a regional center for primary percutaneous coronary …
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The interplay between pro-death and pro-survival signaling pathways converging at mitochondria in myocardial Ischemia/Reperfusion : Apoptosis meets Autophagy
… of autophagosomes have been reported during myocardial ischemia/reperfusion (I/R) injury, however, whether autophagy functions as a protective or lethal response is unclear. Thus, the main objective of this thesis was to investigate the nature of the relationship between I/R-activated …
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Relationship Between Intravascular Ultrasound Parameters and Fractional Flow Reserve in Intermediate Coronary Artery Stenosis of Left Anterior Descending Artery
… of the left anterior descending artery (LAD). Myocardial ischemia was assessed by FFR and maximal hyperemia was induced by continuous intracoronary adenosine infusion. FFR < 0.80 was considered as significant inducible myocardial ischemia. We performed standard IVUS parameter measurements and …
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Apoptosehemmung durch Zink im Myokardinfarkt
… potential anti-inflammatory effects of Zinc in a myocardial ischemia and reperfusion model and in a hypoxie-model without reperfusion in the rat heart. With the TUNEL method the apoptotic cells were marked.
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Cardioprotective treatment strategies
In myocardial ischemia-reperfusion (I/R) injury, complement activation, tissue plasminogen activator (t-PA) and extracellular adenosine triphosphate (ATP) release contribute to myocardial injury. ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective …
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