Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"myocardial infarct size"”.
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Pharmacological interventions against myocardial ischemia and reperfusion injury
… important factor to reduce the injury caused by myocardial ischaemia, reperfusion in itself can aggravate the damage to myocardial tissue, a phenomenon denoted myocardial reperfusion injury. Even though promising cardioprotective strategies have been presented in the pre-clinical setting, …
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Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences.
… the GPR55 knockout and HFD intervention on the myocardial infarct size sustained following a period of ischaemia/reperfusion (I/R) and 3) make use of an in vitro model to elucidate the mechanisms by which changes occur in the adipose tissue of mice fed a HFD. GPR55-/- mice fed a HFD for 12-weeks …
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Effects of nitrite infusion on skeletal muscle vascular control during exercise in rats with chronic heart failure
… with and without NO[subscript]2- infusion. The myocardial infarct size (35 ± 3%) indicated moderate CHF. NO[subscript]2- infusion increased total hindlimb skeletal muscle VC (CHF: 0.85 ± 0.09, CHF+NO[subscript]2-: 0.93 ± 0.09 ml•min[superscript]-1•100g[superscript]-1•mmHg[superscript]-1, p<0.05) …
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Acute Myocardial Infarction: The Relationship between Duration of Ischaemia and Infarct Size in Humans - Assessment by MRI and SPECT
The effect of duration of ischaemia on final infarct size is well established in animal studies, but not fully evaluated in humans. Delayed contrast-enhanced magnetic resonance imaging (DE-MRI) can be used to distinguish between viable and non-viable myocardium and thus to quantify infarct size. We …
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NOVEL STRATEGIES TO IMPROVE METABOLIC PARAMETERS AND PRECONDITION DIABETIC HEARTS AGAINST ISCHEMIA/REPERFUSION INJURY
… of miR-103/107 is caveolin-1 (Cav-1). We hypothesized that daily administration of the phosphodiesterase-5 inhibitor tadalafil (TAD) ± the curcumin analogue (HO-3867) will attenuate inflammation, improve metabolic parameters and reduce infarct size after ischemia/reperfusion injury (IRI). …
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Prenatal Cocaine Exposure and Cardiac Programming
… injury in juvenile and adult rats by increasing myocardial infarct size and decreasing postischemic recovery of left ventricular function. Interestingly, the effect of prenatal cocaine exposure on cardiac vulnerability in adult offspring is gender-dependent, with the male heart being more …
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Assessment of myocardial viability using magnetic resonance imaging
Myocardial infarction (MI) following an acute coronary occlusion is a leading cause of morbidity and mortality. During revascularization, microemboli may complicate treatment and affect cardiac function. The long-term effects of microembolization are not fully elucidated. Following an MI it is …
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Coronary Reactive Hyperemia
… an increased release of t-PA. It was also hypothesized that hypothermia may have effects on coronary reactive hyperemia and that rapidly induced hypothermia prior to reperfusion in an infarction model could reduce myocardial infarct size. Material and Methods: All studies were performed in a …
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Investigating the role of toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury
… additional research is required. Recently myocardial inflammation has drawn increasing interest as a potential therapeutic against cardiovascular disease. Because inflammation is activated by a broad range of pro-inflammatory mediators, the innate immune response can be suppressed at …