Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"myocardial fibrosis"”.
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Cardiac magnetic resonance imaging for non-invasive detection of myocardial fibrosis
… and aged population. This research focuses on myocardial fibrosis, a precursor of cardiovascular diseases. At least initially, myocardial fibrosis is a healing response when the human heart is injured or inflamed. An increase in the deposition of collagen I and collagen III occur in the heart …
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Myocardial fibrosis and pathological hypertrophy in the rat with aorta-constricted hypertension
… ischemia. Microscopically, marked interstitial fibrosis with focal necrosis and diffuse perivascular fibrosis in the myocardium were observed. Myocardial fibrosis appears before myocyte necrosis and its severity is proportional to the duration of established hypertension and the magnitude of …
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Predictors of diffuse myocardial fibrosis in HIV infected persons: A multiparametric cardiovascular magnetic resonance study
… that ART would be associated with regression of myocardial fibrosis in HIV. Myocardial fibrosis is associated with an unfavourable outcome in many different clinical settings. In this study, we used cardiovascular magnetic resonance (CMR) measurements of extracellular volume fraction (ECV) and …
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MULTIPARAMETRIC SCORE FOR PREDICTION OF MYOCARDIAL FIBROSIS IN PATIENTS WITH MITRAL VALVE PROLAPSE: THE SCIMITAR TRIAL
Introduzione. Un sottogruppo di pazienti con prolasso della valvola mitrale (PVM) — in particolare quelli affetti da malattia di Barlow — può sviluppare aritmie ventricolari (AV) e morte cardiaca improvvisa. Diverse caratteristiche cliniche e di imaging sono state proposte come potenziali fattori …
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The role of myocardial fibrosis and ventricular mechanical dyssynchrony in the pathogenesis and treatment of contractile myocardial dysfunction.
… cascade between these initiators of myocardial dysfunction and its overt manifestation has been incompletely characterised. Amongst the proposed intermediaries of systolic heart failure, recent attention has focussed on myocardial fibrosis and ventricular dyssynchrony. Myocardial …
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Fibroblast Growth Factor-23 and Cardiac Magnetic Resonance Indices of Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis
… of Fibroblast Growth Factor-23 (FGF-23) with myocardial fibrosis using cardiovascular magnetic resonance (CMR) imaging techniques. Higher levels of Fibroblast Growth Factor-23 (FGF-23) have been linked to increased risk of all-cause mortality, cardiovascular mortality, left ventricular …
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
… distinct pathological condition characterized by myocardial fibrosis and cardiac dysfunction in diabetic patients. The resolution of myocardial fibrosis to improve cardiac function in diabetes is an active area of research. Notably, increased T lymphocyte infiltration into myocardium has been …
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MRI determined tissue characterization of myocardial infiltration and fibrosis in cardiomyopathy
… is the diffuse interstitial or replacement myocardial fibrosis. Myocardial fibrosis leads to impaired cardiac diastolic and systolic function and can lead to increased cardiovascular morbidity and mortality. Cardiac Magnetic Resonance Imaging (CMRI) with contrast can be used to characterize …
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Correlation of signal-averaged electrocardiogram and late gadolinium enhancement cardiovascular magnetic resonance in the detection of myocardial fibrosis in arrhythmogenic right ventricular cardiomyopathy and other myocardial disorders
… and supraventricular tachycardias had no myocardial LGE on CMR. Comparing patients with LGE and those without LGE on CMR, there were no differences in fQRS, (114ms [102.3 – 119] versus 111ms [99.5 -130], p = 0.608); LAS40 (34.5ms [16.8 - 40.8] versus 31ms [27.5 – 45], p = 0.566) and a …
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Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers
… of anthracycline chemotherapy on measures of myocardial injury and fibrosis using quantitative cardiovascular magnetic resonance (CMR) imaging techniques. Anthracycline-based chemotherapy regimens are often an essential component of curative cancer treatments, but are associated with …
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FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE
… with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are currently unclear.
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Cardiorespiratory abnormalities in early and advances stage mouse models of Duchenne muscular dystrophy
… this study was to investigate the time course of myocardial fibrosis and respiratory decline in a mouse model of DMD. The extent of fibrosis was determined in histological sections using planimetry. We found that 16-month-old DMD hearts were in early stages of myocardial fibrosis, with 9.6 +/- …
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Exercise-Associated Cardiac Rhythm Disorders in Thoroughbred Racehorses
… strenuous exercise, cardiac arrhythmias and myocardial remodelling in TBs. A mobile based electrocardiography (ECG) device was validated for recording post-race cardiac arrhythmias in TBs. The device algorithm was accurate in identifying AF episodes. In horses with AF, abnormal, wide QRS …
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Cardiac magnetic resonance imaging assessment of aortic stenosis to improve clinical care
… and may leave many patients with irreversible myocardial damage and adverse outcomes following valve intervention. The aims of this thesis are to investigate novel cardiac magnetic resonance techniques and how they can be applied to improve our decision making around the timing of valve …
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Magnetic resonance imaging of the right ventricle in human pulmonary hypertension
… and revealed previously unidentified areas of myocardial fibrosis within the RV insertion points and interventricular septum. The extent of these areas correlated inversely with RV ejection fraction (r = -0.762, p < 0.001). Septal contrast enhancement was particularly associated with bowing of …
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Cardiovascular magnetic resonance characterisation of myocardial involvement in tuberculous pericardial constriction with and without HIV co-infection
… myopericarditis. However, little is known about myocardial involvement in patients with pericardial tuberculosis. Cardiovascular magnetic resonance (CMR) can assess non-invasively cardiac function, myocardial oedema, inflammation and fibrosis. Objectives: To assess cardiac and pericardial …
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Investigating the pathways involved in the progression of fibrosis in tuberculous pericarditis
… mechanisms involved in the development of fibrosis in TBP, and b) the potential of ACE inhibitors (ACEi) for managing fibrosis progression. Pericardial fluid was obtained from patients with TBP and patients undergoing coronary artery bypass surgery (non-infectious controls). Label-free …
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Manganese porphyrin for Synthesis of Targeted Contrast Agents for Improving Specificity in Cardiac Magnetic Resonance Imaging
… I binding ligand provided specific imaging of myocardial fibrosis. Functionalization of Mn3+ porphyrin with a nitric oxide reactive moiety provided specific contrast to myocardial inflammation. Finally, Mn3+ porphyrin was conjugated with several biomaterials, including; collagen, polyurethane …
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Expression and Regulation of Osteopontin in the Diabetic Heart
… in cardiac structure, one of which is fibrosis of the ventricular myocardium. Myocardial fibrosis is a common underlying factor in most cardiac pathologies. Osteopontin (OPN) is a small phospho-protein that has been implicated in fibrotic tissue remodeling. In the heart, the expression …
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Model-based Analysis of Myocardial Microstructure for Left Ventricular Mechanics using MRI
… (HF) remain largely unexplained. Increased myocardial tissue stiffness, diffuse fibrosis, and tissue remodelling have been identified as contributors to HF. However, their biomechanical effects are not well understood. In this thesis, the link between intrinsic mechanical properties of the …
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