Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"myelopoiesis"”.
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Dietary regulation of myelopoiesis and stromal cell isolation
… atherosclerosis in part by promoting increased myelopoiesis. Previous work showed that high dietary salt intake may enhance myelopoiesis. This suggests that salt-induced myelopoiesis may be a novel pro atherosclerotic mechanism. Here, the effect of two NaCl-supplemented diets on myelopoiesis was …
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Effect of CDDO-me on Myelopoiesis in Naive Mice and Mice Undergoing Bone Marrow Transplantation (BMT)
… with CDDO-me (120 μg/dose BID) enhanced myelopoiesis and caused mobilization of myeloid and myeloid progenitor cells into the spleen and blood.
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Erk1 and Erk2 in hematopoiesis, mast cell function, and the management of Nf1-associated leukemia and tumors
… combined Erk1 and Erk2 roles in HSC function, myelopoiesis, and mature mast cell physiology remain unknown, and recent hematopoietic studies relying on chemical Mek-Erk inhibitors have produced conflicting results. Here, we show that hematopoietic stability, myelopoiesis, and mast cell …
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Profiling, prototyping, and perturbing human immune responses
… system that models sepsis-induced emergency myelopoiesis using human cells.
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Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248
… activity of C/EBPa is regulated both in myelopoiesis and leukemogenesis, is not fully understood. The current study demonstrates that activated Ras enhances the ability of C/EBPa to transactivate the G-CSF receptor promoter and a minimal promoter containing only C/EBP DNA binding sites. …
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IL-27 AND THE REGULATION OF INNATE AND ADAPTIVE IMMUNITY DURING TOXOPLASMOSIS
… events during infection-induced emergency myelopoiesis revealed that haemopoietic stem cells in the bone marrow express high levels of the IL-27R and that during infection IL-27 is a negative regulator of their differentiation into monocytes. Additionally, these studies revealed that IL-27 …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
… focus on microenvironmental regulation of myelopoiesis/megakaryopoiesis in response to neuronal inputs. During normal ageing, HSC niches decrease near bone but expand further from bone. Adrenergic signalling regulates lymphoid-myeloid balance during ageing. Whereas β2-AR promotes myeloid …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
… we provide evidence for a strict separation of myelopoiesis and lymphopoiesis, not being the first lineage commitment step of HSCs.
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
… organ development, B cell lymphopoiesis, and myelopoiesis. In addition to regulating the noncanonical NF-kB pathway, NIK is also involved in regulation of kB dimers of the canonical NF-kB pathway and can function independent of NF-kB signaling by regulating lipid and glucose metabolism, …
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Role of microRNA-155 in dendritic cells and macrophages: MiR-155 directly targets PU.1 and IL13Rα1
… PU.1 is a transcription factor essential in myelopoiesis and dendritic cells (DCs) that favours a Th<sub>2</sub> profiling; moreover, PU.1 had been shown to regulate the transcription of DC-SIGN (Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin 1) which is a pathogen receptor expressed in …
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Deciphering pre-leukaemic dysregulation caused by mutant C/EBPα at the level of the single cell
… because it is a significant player in normal myelopoiesis, it interacts with other transcription factors (TFs) in lineage specification, and the CEBPA gene has been identified as an early mutation in acute myeloid leukaemia (AML). N321D is a mutation affecting the leucine zipper domain of …
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Hematopoiesis: Functional Insights by Cell Fate Conversion
… of multipotent GMLPs by strongly favoring myelopoiesis over lymphopoiesis. This indicates that Hlf is a key determinant of lineage fate and an important component in the regulatory networks of multipotency.
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The Impact of Heat Stress on Immune Function
… In parallel, heat stress promoted stress-driven myelopoiesis. These alterations were accompanied by persistent peripheral lymphopenia, initially due to increased cell death and later due to impaired replenishment of peripheral niches. The surviving leukocyte populations appeared primed and …