Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"myeloperoxidase"”.
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The Impact Of Myeloperoxidase And Its Related Oxidants On Metaphase Ii Mouse Oocyte Quality
… (HOCl), as well as, the pro-inflammatory enzyme myeloperoxidase (MPO). Previously, it has been shown that these ROS have deleterious effect on oocytes; however the link between inflammation through macrophage activity and oocyte quality remains unclear. In this work, we investigated: 1) the …
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The Expression of Neutrophil Products, Myeloperoxidase and Matrix Metalloproteinase 8, in Systemic Vasculature of Obese and Preeclamptic Women
… whether expression of neutrophil products, myeloperoxidase (MPO) and matrix metalloproteinase 8 (MMPS), was associated with neutrophil infiltration in systemic vascular tissue of obese and preeclamptic women. I tested my hypotheses by using immunohistochemical studies to look at the …
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Bystander-Effekt des Peroxynitrit und der toxische Effekt von Cu(II)-SOD
… Reiz des Wasserstoffperoxids wird durch Myeloperoxidase in den für transformierte Zellen spezifischen und selektiven Apoptoseinduktor HOCl umgewandelt. HOCl induziert in transformierten Zellen selektiv Apoptose, indem es mit Superoxidanionen transformierter Zellen zu ?OH reagiert. <br>Für …
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Effects of in vivo dexamethasone sodium phosphate on in vitro equine neutrophil function
… lysozyme, $\beta$-glucuronidase, and myeloperoxidase was quantitated and was not affected by treatment.
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PROTECTION OF ISCHEMIA REPERFUSION INJURY IN MURINE LIVER BY GENE SILENCING OF COMPLEMENT 3
… (AST). Neutrophil accumulation was determined by myeloperoxidase assay. Oxidative stress was assessed by malondialdehyde and reactive oxygen species levels. In comparison with control mice treated with scrambled shRNA, the serum levels of ALT and AST were significantly reduced in mice treated with …
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Early Mediators of Cutaneous Ischemia Reperfusion Injury: A Mouse Model
… of oxidative stress and inflammation such as myeloperoxidase and matrix metalloproteinases were measured at time points 1, 3, & 5 days post-injury. A sharp increase in MPO and MMP-9 was witnessed throughout, with the highest concentrations found at day 1. Simultaneously, immunodetection of …
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Selektive und nichtselektive Apoptoseinduktion durch Reaktive Sauerstoffspezies
… – ein großes Potential aufweist. <br>Das Enzym Myeloperoxidase wandelt Wasserstoffperoxid in den selektiven Apoptosemediator HOCl um, welcher über die Reaktion mit Superoxidanionen der transformierten Fibroblasten das hochreaktive Hydroxylradikal bildet und so Apoptose in diesen Zielzellen …
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L'infiammazione intestinale nell'animale sperimentale come modello per lo sviluppo di nuovi farmaci: ruolo della via tachichininergica nelle malattie infiammatorie intestinali
… by means of macroscopic and microscopic scores, myeloperoxidase activity (MPO) and TNF-α tissue levels. Enzyme immunoassay was used to measure colonic substance P levels. Statistical analysis was performed using analysis of variance (one-way or two-way, as appropriate) with the Bonferroni�s …
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Biomarcadores relevantes para diagnóstico precoce e prevenção de doenças cardiovasculares.
… AI / apolipoprotein B , natriuretic peptides and myeloperoxidase are biomarkers nontraditional whose predictive power and clinical application are under discuss ion . CRP, homocysteine , Lp (a) Lp - PLA2 and MPO act in pathophysiological mechanisms stimulating the atherogenic and thrombogenic …
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Neutrophil extracellular traps in periodontitis
… NET release implicating a regulatory role for myeloperoxidase generated hypochlorous acid in NET production. In conclusion, the results contained within this thesis indicate a putative role for NETs in the pathogenesis of periodontitis and highlight a high prevalence of potential counter-NET …
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Acoustically-levitated drop reactor (ldr) employable for kinetics measurements of biochemical networks
… effects of laser exposure on the stability of Myeloperoxidase at the liquid/gas interface. It was found that although myeloperoxidase degrades over several hours in buffer, there is no indication that the degradation is due to either denaturation at the free surface or to two-photon photolysis. …
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A bioengineered approach for sustainable crude oil pollution treatment via entrapment, dispersal and removal using Nano-CarboScavenger
… Finally, NCS degraded in the presence of human myeloperoxidase (HMPO) and horseradish peroxidase (HRP), suggesting any incidental biological uptake can be enzymatically digested in living systems.
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The Role Of Oxidative Stress In The Pathogenesis Of Epithelial Ovarian Cancer
… novel finding from our laboratory has shown that myeloperoxidase (MPO) is expressed in ovarian cancer cell lines and tissues, with minimal or no expression detected in normal ovarian tissues. Myeloperoxidase is an abundant heme protein, which plays a central role in the formation of reactive …
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Analysis of the peroxidase-catalysed oxidation of hydroxamic acids
… site of a model peroxidase (horseradish, LPO; myeloperoxidase, MPO) was used to provide insight into structure-function relationships of peroxidases. Hydroxamic acids acted as inhibitors of the native state (E), by formation of an E-hydroxamic acid complex that prevents H2O2 from binding. …
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Differenzierungsabhängige Modulation der Zytokin- und Chemokinexpression bei humanen myeloischen Zell-Linien
… CD154, Glykophorin A, HLA-DR), der Zytochemie (Myeloperoxidase, Lysozym, unspezifische Esterase) und der Zellmorphologie untersucht. Es zeigte sich, daß sich das Zytokin- und Chemokinprofil in Gegenwart von Differenzierungsinduktoren quantitativ und qualitativ verändert. Für die erythrozytäre …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… of microglial NADPH oxidase and astroglial myeloperoxidase (MPO), and subsequent reactive oxygen species (ROS)/reactive nitrogen species (RNS) production and oxidative DNA damage in the MPTP-treated substantia nigra. Additional immunohistochemical staining also showed that MPTP induced glial …
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Role of Chitinase in the development of work-related symptoms in bakery workers
… IL-18 유의한 양의 상관관계가 있었으나(P<0.001), 혈청 TNFa, myeloperoxidase(MPO) 치와는 유의한 상관성이 없었다. 본 연구에서는 혈청 Chitinase의 농도는 밀가루 분진 노출의 한 지표가 될 수 있고, Toll 유사 수용체 4의 유전자 다형에 따른 혈청 Chitinase의 농도의 관련성, 선천 면역 사이토카인과의 연관성을 확인하여, 제빵공 천식의 발생에 선천성 면역 반응이 관여할 가능성을 제시한다.
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The role of complement and granulocyte colony stimulating factor in ANCA associated vasculitis
… necrotising glomerulonephritis in 1982, with myeloperoxidase )) and proteinase 3 (PR3) subsequently shown to be the antigenic targets responsible rthe perinuclear and cytoplasmic staining patterns, respectively. Infection is thought to erbate disease partially through the production of the …
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Role of Manganese Superoxide Dismutase in Chemotherapy-induced Oxidative Stress
… Individuals carrying minor allele SNPs in myeloperoxidase (MPO) and an aldo-keto reductase (AKR1C3) were found to be associated with shorter time to disease progression and death. This data suggest that some patients may benefit from a different therapy than the current standard of care and …
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Protective Effects of Yuzu and Its Component against Cardiovascular Disease
… also hesperidin inhibited caspase-3 activity, myeloperoxidase expression, α-smooth muscle actin expression, and matrix metalloproteinase-2 activity in a permanent LAD occlusion rat model. These results suggest that yuzu and hesperidin have anti-platelet activity, and that intake of yuzu, which …
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