Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"myeloische Leukämie"”.
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Mit AML assoziierte MLL-partielle Tandemduplikationen (MLL-PTD) sind in Stammzellen aus Nabelschnurblut lebenslang nachweisbar
Die akute myeloische Leukämie ist eine seltene Erkrankung, welche überwiegend im höheren Lebensalter, aber auch nach Exposition gegenüber einer hohen Dosis ionisierender Strahlung oder gegenüber bestimmten Zytostatika, welche in der Behandlung anderer primär maligner Erkrankungen eingesetzt werden, …
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Zur epigenetischen Inaktivierung der Wnt-Antagonisten SFRP-1, -2, -4 und -5 bei der Akuten Myeloischen Leukämie
Acute myeloid leukaemia (AML) originates in the transformation of hematopoietic stem cells, leading to clonal proliferation of immature progenitor cells and severe multilineage bone marrow suppression. In addition to numerous genetic aberrations in AML, it has become evident that epigenetic …
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Entwicklung, Optimierung und Charakterisierung anti-CD64-basierter Immuntherapeutika
Immunotoxins (ITs) commonly are composed of modified antibodies that are linked to a toxin either chemically or through the generation of a fusion protein. The antibody directs the IT to specific target cells where it binds to surface molecules and is internalized, allowing the cytotoxic component …
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Evaluation von KIR-Liganden Inkompatibilität bei unverwandten Knochenmark-/ Stammzelltransplantationen
We performed a retrospective study in 185 patients with myelogenous leukemias who had received hematopoietic cells from unrelated donors. The aim of this study was to answer the question wether the benefit of KIR ligand incompatibility seen in haploidentical tranplantations can also be seen using …
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Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie
Based on the role of epigenetic changes as an alternative mechansim of transcriptional inactivation of cancer-related genes in hematopoietic malignancies as well as the relevance of CCAAT/enhancer binding protein alpha (C/EBP alpha) in early stages of myeloid differentiation and regulation we …
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Plasmacytoid dendritic cells and neutrophils : underestimated cell populations during the onset of atherosclerosis
This study focuses on the understanding of the pathophysiological role of neutrophils and plasmacytoid dendritic cells in atherosclerosis. Atherosclerosis is now agreed to be a chronic inflammatory disease of the vessel wall driven by intense immunological activity, of both, innate and adaptive …