Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"myeloid dendritic cells"”.
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Monocytic Cells Mediate Granulocyte-Colony Stimulating Factor-Induced Mobilization of Hematopoietic Stem and Progenitor Cells
… a majority of hematopoietic stem and progenitor cells: HSPCs) are tightly held within specialized areas of the bone marrow collectively referred to as the `hematopoietic stem cell niche.' In response to various forms of stress, such as infection or hemorrhage, or following administration of a …
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Determinants of innate immune responses to mycobacteria
Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the …
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
… of the Toll-like receptors (TLRs) in the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with the endogenous cationic antimicrobial peptide LL37, which are internalized into the endosomal …
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Biomarkers in sepsis and other severe infections
… I) we examined surface markers on white blood cells from patients with severe infections. In some instances our analysis could differentiate between infections of bacterial and viral origin. In the second part (paper II-IV) we examined the incidence and nature of the immune alterations found in …
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Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
… of tolerance to nuclear antigens. Hyperactive B cells are present in SLE patients and murine models of lupus, many of which have defects in inhibitors of B cell receptor (BCR) signaling or plasma cell differentiation. Autoantibodies against a wide range of self antigens contribute to the …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
… effector WNV-specific IFN-γ secreting CD8+ T cells, the development of anti-WNV CD4+ and CD8+ memory T cells and the role of TLR3- and MyD88-dependent signaling in modulating antigen presenting function of myeloid dendritic cells. We examined and compared the role of TLR3- and MyD88-dependent …
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Influence of dietary interventions on the immune system: an investigation of the impact of omega-3 fatty acids, dietary fermentable materials and high energy diets
… circulating percentages of CD282+/TLR2+ myeloid Dendritic cells (mDC) and ex vivo responsiveness to a Toll-like receptor 2 (TLR2) agonist, while serum IL-10 concentrations decreased. A rat trial was designed to examine effects of a HE diet supplemented with varied DFM (7% wheat bran, oat …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… infection across the vaginal mucosa. Epithelial cells, which form the primary barrier of protection against pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV infection has not been clearly elucidated. Although mucosal epithelial cells express …
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Deficiência de arginina-vasopressina (diabetes insipidus central) como primeira manifestação de histiocitose de células de Langerhans: relato de caso
… by proliferation of CD1a⁺/Langerin⁺ myeloid dendritic cells and activating mutations in the MAPK/ERK pathway (such as BRAF V600E and MAP2K1). Involvement of the hypothalamic–pituitary axis occurs in up to 30% of cases, presenting as arginine-vasopressin (AVP) deficiency—classically …
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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
… which are enhanced following reinfection. Dendritic cells (DCs) including myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) play important roles in driving host responses to RSV infection. mDCs present antigens to help Th cells differentiate, and pDCs protect against viral infection through …
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The immunomodulatory properties of Vitamin D in vitro and in vivo
… evidence for significantly higher frequency of myeloid dendritic cells, and lower frequency of Foxp3+ CD4+ T cells in the peripheral blood of SR as compared to SS asthmatics. The accepted measure of vitamin D status is serum 25-hydroxyvitamin D3, 25(OH)D, and the severe asthmatics had …
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Visualizing The Dynamics of Immune Surveillance In Brain Tumors By Intravital Multiphoton Microscopy
… of T cell surveillance in BTs. Resident immune cells of the myeloid lineage known as microglia are ubiquitous in the brain parenchyma while tissue-resident myeloid dendritic cells (DCs) known to activate T cells are relatively rare in the brain compared to DCs in other organs. Accumulating …
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Interaktion des Frühsommer-Meningoenzephalitis- Virus mit antigenpräsentierenden Zellen
… DCs in zwei Hauptgruppen aufgeteilt werden, die myeloiden- und plasmazytoiden dendritischen Zellen (mDCs und pDCs). Während die mDCs die potenteren APCs sind, können die pDCs in Antwort auf eine virale Infektion binnen kurzer Zeit große Mengen an Typ I Interferonen produzieren, die dazu beitragen …