Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"myeloid cells"”.
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Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis
Immune cells play paradoxical roles in cancer progression. On one hand, the immune system protects us against tumor development by recognizing and eliminating cancerous cells. On the other hand, tumor-associated immune cells can contribute to tumor progression by secreting growth factors as well as …
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Hypoxic Influences On Myeloid Cells During Inflammation And Inflammation-Associated Cancer
… are key regulators of inflammatory responses in myeloid cells. This body of work investigates the role of myeloid HIF-αs in the settings of several acute and chronic inflammatory diseases. First, the role of pan-HIF signaling in acute intestinal inflammation is investigated by depleting myeloid …
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Therapeutic Strategies to Target LILRB Receptors on Myeloid Cells for Cancer Immunotherapy
… not all patients with cancer. Immunosuppressive myeloid cells which inhibit anti-tumor immunity are recognized as one of the major obstacles in cancer treatment. LILRB3 and LILRB4, immune inhibitory receptors containing tyrosine-based inhibitory motifs (ITIMs), are expressed solely on myeloid …
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Investigating the susceptibility of foreskin myeloid cells to ex vivo HIV infection
… populations of innate and adaptive immune cells, that are permissive to HIV infection5–8. In support of this, medical male circumcision (MMC), has been reported to confer up to 60 % risk reduction in HIV acquisition9–17. Most studies have focused on investigating blood lymphoid immune cells …
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27-Hydroxycholesterol promotes breast cancer progression through the modulation of myeloid cells
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Myeloid cells induce neurofibromatosis type 1 aneurysm formation through inflammation and oxidative stress
… activity in both hematopoietic and vascular wall cells, which are critical for maintaining blood vessel homeostasis. NF1 patients are predisposed to chronic inflammation and premature cardiovascular disease, including development of large arterial aneurysms, which may result in sudden death …
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Characterization and Regulation of Insulin-Like Growth Factor-Imrna Transcripts in Myeloid Cells
… 40 fold higher levels of IGF-I mRNA than B or T cells and macrophage transcripts initiated exclusively within exon 1, characteristic of extra-hepatic tissues. Surprisingly, macrophage IGF-I mRNA transcripts contained a proportion of IGF-I Eb transcripts which was equal to, or greater than, that …
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Molecular interactions among insulin-like growth factor, its receptor and binding proteins on myeloid cells
… a greater population of CD4$\sp-$CD8$\sp-$ cells and a reduced percentage of CD4$\sp+$CD8$\sp+$ lymphocytes compared to those of young rats. These age-associated changes could be reversed by implanting the growth hormone (GH) secreting cells, GH$\sb3$. To understand the molecular mechanism …
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Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… of the lung that leads to granuloma formation. Myeloid lineage immune cells play a critical role in the early and late stages of the disease, and this activity is mediated through toll-like receptors (TLRs) expressed by these cells. Protein kinase D1 (PKD1) has previously been identified as a …
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Modulation of Host BRD4 to Repress HIV Replication in Myeloid Cells: Major HIV Reservoirs in Central Nervous System
Brain-resident microglia and myeloid cells (perivascular macrophages) are important HIV reservoirs in vivo, especially in central nerve system (CNS). Despite anti-retroviral therapy (ART), low-level persistent HIV replication in these reservoirs remains detectable, which contributes to …
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Novel cytokines in innate immunity: IL-27 and IL-30 enhance responsiveness to gram-negative bacterial components in human myeloid cells
In response to microbial stimuli, innate myeloid cells are potent producers of cytokines that function to mediate inflammation. This thesis investigates two related cytokines, IL-27 and IL-30, to identify novel proinflammatory mechanisms to improve treatments for bacterial infections. IL-27 is …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
… compose the tumor microenvironment (TME). The myeloid cells play a major role in TME and can be composed of heterogeneous cells with functions that can be grossly summarized as: (1) Antigen capture for presentation (dendritic cells, DCs) or for degradation (macrophages); (2) Tissue repair …
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
… of VEGFR2 expression on tumor-associated myeloid cells in tumor-bearing animals. I further investigate the function of VEGFR2+ myeloid cells in regulating tumor immunity and find VEGF induces an immunosuppressive phenotype in VEGFR2+ myeloid cells including directly upregulating the …
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THE ROLE OF THE STRESS RESPONSE GENE GADD45A IN MODULATING MYC MEDIATED APOPTOSIS AND DIFFERENTIATION
… sensors that modulate the response of mammalian cells to different stressors, including oncogenic stress. Gadd45a expression is regulated during myeloid cell differentiation, and is also induced in response to acute stimulation with cytokines, myeloablation and inflammation. The proto-oncogene …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
Triggering receptor expressed on myeloid cells – 2 (TREM-2) is a receptor expressed mainly in myeloid cells. TREM-2 is involved in the resolution of inflammation through dampening Toll-like receptor (TLR) induced pro-inflammatory cytokine secretion and phagocytic functions. It is increased in …
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Investigating the Therapeutic Potential of L-asparaginase in Myeloid Leukemia
Acute myeloid leukemia (AML) is a malignant disease of the bone marrow that results in the proliferation and accumulation of dysfunctional myeloid cells and the disruption of the normal hematopoietic process. The high rate of relapse and diversity of the disease at the genetic and epigenetic level …
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Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
… the numbers of granulocytes, undifferentiated myeloid cells, and macrophages at infection sites. MPLA treatment also increased the percentage and total numbers of myeloid cells mediating phagocytosis of bacteria. Depletion of monocytes did not eliminate the enhanced bacterial clearance induced …
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Unveiling Immune Checkpoint Therapy Resistance Mechanisms In The Tumor Microenvironment Using High-Dimensional Analyses
… microenvironment (TME), including suppressive myeloid cells, regulatory T cells (Tregs), and cancer-associated fibroblasts (CAFs), plays a pivotal role in ICT responses. Leveraging single-cell technologies, this study explores the role and function of immune subsets in the TME that induce …
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The Recruitment and Function of Tumor Microenvironment Components During Gastric Carcinogenesis
… been rightly paid to the behavior of transformed cells, some focus has recently shifted to the components of the soil in which tumors develop and grow, commonly referred to as the microenvironment. Here, we investigate the gastric tumor microenvironment and shed light on the role of …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
… downregulation in metastatic breast tumor cells activates PI3K/NF-ƙB signaling and increases the secretion of the chemokine CCL2, which enhances the chemotaxis of CCR2<sup>+</sup> myeloid cells, a major subpopulation of bone marrow-derived myeloid cells (BMDMs), from peripheral blood into …
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