Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"myelofibrosis"”.
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Primary Myelofibrosis, Post-Erythremia Vera and Post- Essential Thrombocythemia Myelofibrosis - Impact of Inflammatory Cytokines (Interleukin 6, Interleukin 8) and Regulators of Iron Metabolism (Hepcidin) in The Pathogenesis of Anemic Syndrome // Първична, пост-еритремична, пост-тромбоцитемична миелофиброза - участието на инфламаторни цитокини (interleukin 6, interleukin 8) и регулаторите на железния метаболизъм (хепсидин) в патогенезата на анемичния синдром
Миелофиброзата (МФ) е клонална хематологична неоплазия с хетерогенна клинична изява, прояви на фибротично заместване на кръвотворенето, костно-мозъчна недостатъчност, екстрамедуларна хемопоеза, ексцесивна спленомегалия и наличие на тежък анемичен синдром. Подозиран фактор в развитието на анемия при …
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Determinants of clinical phenotype in myeloproliferative neoplasms
… vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates. The genomic characterization of patients with myeloproliferative neoplasms offers the potential for personalized diagnosis, risk stratification, and treatment. Methods: We …
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Detection of the calreticulin type 1 and type 2 mutations in a group of myeloproliferative neoplasm patients using molecular methods
… essential thrombocythaemia (ET) and primary myelofibrosis (PMF) or myelofibrosis (MF). In 2013, somatic mutations at exon 9 of CALR, the gene that encodes for calreticulin, were discovered through whole-exome sequencing and targeted re-sequencing in patients with MPNs. Among these mutations, …
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Implementation of the JAK2V617F mutation analysis in the pathway of suspected myeloproliferative neoplasms in Groote Schuur Hospital
… (n=41, 42% JAK2 mutated); primary myelofibrosis (n=28, 57% JAK2 mutated). The 2016 WHO haemoglobin/haematocrit thresholds in PV were validated. Idiopathic erythrocytosis (IE) found in 44 patients. Bone marrow histology, but not serum EPO level, was essential to differentiate between …
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Inferring Clonal Dynamics in Blood using Single-Cell Measurements
… (ET), polycythemia vera (PV), or primary myelofibrosis (PMF)—and the reason for this variation remains unknown. One compelling hypothesis is that the JAK2-V617F mutation may arise in HSC subsets with intrinsic biases toward platlet-producing cells (as in ET) or red blood cell precursors …
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The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
… (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling pathway molecules and a variable tendency to develop acute myeloid leukaemia (AML). This thesis examined genotype-phenotype …
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New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
… in essential thrombocythemia and primary myelofibrosis, two myeloproliferative neoplasms (MPNs) characterised by megakaryocyte hyperplasia. Despite the large body of research built around CALR mutations, many aspects of the oncogenic mechanisms of CALR in MPNs remain unanswered. This …
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The molecular pathogenesis of myeloproliferative neoplasms
… essential thrombocythaemia (ET) and primary<br/>myelofibrosis (PMF) are characterised by a single acquired mutation, JAK2 V617F. My study has<br/>focused on four principal areas:<br/><br/>(i) Involvement of V617F in other myeloid disorders. After developing sensitive methods to<br/>detect and …
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Sequenzbiopsien und Verlaufsbeobachtung bei der Idiopathischen/Primären Myelofibrose
Das Krankheitsbild der CIMF, das zum Formenkreis der Ph- CMPE gehört, ist gekennzeichnet durch eine progrediente Fibrosierung der Markräume. Erst neuere Untersuchungen weisen darauf hin, dass die Markfibrose kein obligates diagnostisches Kriterium darstellt und keine Abgrenzung von anderen …