Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"myelodysplastic syndrome (MDS)"”.
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PATTERN OF INNATE IMMUNITY IN PATIENTS AFFECTED BY MYELODYSPLASTIC SYNDROME (MDS) EITHER BEFORE ANDAFTER HEMATOPOIETIC STEM CELL TRANSPLANT (HSCT)
Myelodysplastic syndromes (MDS) are a heterogenous group of myeloid neoplasms that primarily affect elderly people and, in the context of population aging, MDS incidence is set to increase substantially. MDS patients have a variable risk of progression to acute myeloid leukemia (AML) and are …
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Role of Selected Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Myelodysplastic Syndrome // Роля на подбрани плазмени микроРНК-и като диагностични и прогностични маркери при миелодиспластичен синдром
… diagnostic and prognostic biomarkers in myelodysplastic syndrome (MDS). The study aims to investigate the expression of these five microRNAs in the plasma of patients with MDS and healthy controls, and to analyse their correlation with clinical, laboratory, and prognostic parameters, …
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Evaluation of the actin architecture in dysplastic megakaryocytes expressing the NUP98-HOXD13 leukemic fusion gene
Some myelodysplastic syndrome (MDS) patients present with macrothrombocytopenia due to impaired megakaryocyte (MK) differentiation. Transgenic mice that express the NUP98-HOXD13 (NHD13) fusion gene is a model for MDS and recapitulates the key features of MDS. The study investigated the hypothesis …
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Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie
… findings in therapy of acute leukemias and myelodysplastic syndrome (MDS). We showed, that in hematopoietic tumor cell lines, CpG island hypermethylation of the proximal C/EBP alpha promotor region was associated with transcriptional silencing, and treatment with the demethylating agent DAC …
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The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function
… potential (CHIP), a potential precursor to myelodysplastic syndrome (MDS), affects over 10% of adults over 65. Loss-of-function ten-eleven-translocation methylcytosine dioxygenase 2 (TET2) variants are common in CHIP and associate with epigenetic dysregulation, inflammation, and …
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
Hypereosinophilic (HES) syndrome is an umbrella term encompassing several disease subsets that affects humans and veterinary species, ultimately resulting in >1,500 eosinophils/uL circulating in the blood documented over six-months. This eventually culminates in end-organ infiltration and increased …
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The Role of Hspa9 in Mouse Hematopoiesis and IL-7 Receptor Signaling
… a commonly deleted region (CDR) associated with myelodysplastic syndrome (MDS), a clonal hematopoietic stem cell disorder. Cytogenetic abnormalities occur in ~50% of MDS patients and an interstitial deletion or loss of chromosome 5 containing HSPA9 is the most common, occurring in up to 25% of …
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Clinical Applicability of Proposed Algorithm For Identifying Individuals At Risk For Hereditary Hematologic Malignancies
… to hematologic malignancies. These syndromes are characterized by an increased risk to develop myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), or aplastic anemia (AA) at young ages, with various phenotypic features including peripheral cytopenias, immune dysfunction and …
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Characterization of 5-methylcytosine dioxygenase Tet2 and rescue of mutant Tet2 activity by using turbo co-substrate
… (TSG). One such epigenetic mechanism observed in myelodysplastic syndrome (MDS) is the acquired progressive methylation of CpG islands in gene promoters, leading to transcriptional repression. The TET family of hydroxylases/dioxygenases, which includes TET1-3, has recently been identified as iron …
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Deciphering the Mechanisms of Heterogeneity within Haematopoiesis in Health, Development & Disease
… in SF3B1-mutant erythroid cells – a common myelodysplastic syndrome (MDS) mutation in a component of the spliceosome. Understanding the intricacies of haematopoietic heterogeneity is crucial, given its implications for various diseases and its relevance to advancements in stem cell …
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Separation and Further Characterization of Hematopoietic Cell Populations Based on Phenotypic and Biophysical Properties
… recipient-derived RBC in a patient with relapsed myelodysplastic syndrome (MDS) following allogeneic HSCT. The presence of the original cytogenetic 20q-deletion in myeloid cell populations of different maturity, suggested an origin common to the original myeloid malignant clone and the reappearing …