Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"myelination"”.
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Mitochondrial metabolism and CNS myelination
… changes. These changes precede the onset of myelination, a process in which oligodendrocyte precursor cells (OPCs) differentiate and engage with axons to invest them with complex multilamellar sheaths. Myelin sheaths enable rapid saltatory signal propagation, synchronised signal conduction, …
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Investigating endothelin receptor B signalling during myelination
… to both positively and negatively influence myelination. I have investigated how EDNRB regulates myelination using an in vitro myelination assay, alongside in vivo analysis in zebrafish and mice. These systems identified a direct signalling role for EDNRB in the promotion of myelin sheath …
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Cohesin Promotes the Myelination Transcriptional Program in Oligodendrocytes
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Axon-glia interactions during central nervous system myelination
Myelination drastically speeds up action potential propagation along axons, which is fundamental for the correct function of neuronal circuits. However, axon-oligodendrocyte interactions regulating the onset of myelin formation remain unclear. I sought to determine how reticulospinal axons control …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
… growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the …
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Diet and respiratory viral infection alter oligodendrocyte homeostasis and myelination processes
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Developmental myelination and myelin plasticity during spatial working memory task acquisition
… (MRI). In order to visualise and quantify myelination patterns and myelin internodes during development, I applied immunohistochemistry and high resolution confocal microscopy. Finally, for establishing whether cognitive learning affects oligodendrocyte differentiation, I employed a …
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Focal adhesion kinase, a major regulator of oligodendrocyte morphological maturation and myelination
… central nervous system. During the process of myelination, oligodendrocytes actively interact with the extracellular matrix (ECM). These interactions are considered crucial for proper and timely completion of the myelin sheath. However, the exact regulatory circuits involved in the signaling …
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OPIOID ADDICTION AND PREGNANCY: POTENTIAL EFFECTS OF SUBSTITUTION THERAPIES ON DEVELOPMENTAL MYELINATION
… induces dose-dependent alterations in rat brain myelination. These time-specific effects suggested that both therapeutic and supra- therapeutic doses of the drug could alter the normal pattern of oligodendrocyte development. In support of this hypothesis, this thesis work has now found that …
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The control of Schwann cell myelination during development and after nerve injury
… of neurons. Schwann cell differentiation and myelination is mediated by a core network of transcription factors and signalling pathways, which have been divided into two groups; positive and negative regulators. Sox10, NFATc4, Oct6, Krox20 and the ERK 1/2 signalling pathway have been …
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Med12 Is A Critical Regulator of Neural Crest Lineage and Nervous System Myelination
… intellectual disability syndromes, demyelination-induced peripheral neuropathies, and depigmentation disorders.</p>
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Estrogen Depletion Effects on Myelination and Lipid Regulation within the Central Nervous System
… of a novel menopausal mouse model of demyelination and Part 2 includes conformational studies of phytate with biologically relevant metals and macrocycles. Menopause has been associated with increased neurodegeneration experienced by multiple sclerosis patients, and this dissertation …
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Calcium/Calmodulin-Dependent Protein Kinase II Beta (CaMKIIβ): A Regulator of Oligodendrocyte Maturation and Myelination
… wrapping myelin around an axon (also known as myelination) are critical for normal development since they ensure proper signal conduction in the vertebrate CNS. The loss or damage of this myelin, which is typically associated with the demyelinating disease multiple sclerosis (MS), is associated …
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OPPOSING ROLES OF THE μ-OPIOID AND NOCICEPTIN/ORPHANIN FQ RECEPTORS IN OLIGODENDROCYTE DEVELOPMENT AND MYELINATION
… nervous system (CNS). Thus, OLG maturation and myelination are highly vulnerable processes along CNS development. We previously showed that rat brain myelination is altered by perinatal exposure to buprenorphine, an opioid analogue in clinical trials for the treatment of pregnant opioid addicts. …
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Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues
Myelination is a key biological process wherein glial cells such as oligodendrocytes wrap myelin around neuronal axons, forming an insulative sheath that accelerates signal propagation down the axon. A major obstacle to understanding myelination is the challenge of visualizing and reproducibly …
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Investigating the role of cellular communication network factor 3 (CCN3) in central nervous system myelination and remyelination
… uncovering the mechanisms that regulate remyelination is an essential task to elucidate druggable targets and improve the quality of life of people living with MS or other demyelinating conditions.<br/><br/>Previously, we reported that regulatory T cells (Treg) are required for efficient …
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Opioid Addiction Treatments During Pregnancy and Their Effects on Axonal Growth and Myelination in the Developing Central Nervous System
… exposure to buprenorphine on axonal caliber and myelination in 26-day-old rat corpus callosum. These changes, detected at the end of rapid brain myelination and accompanied by earlier oligodendrocyte maturation, suggested interference with mechanisms coordinating axonal growth and myelination. To …
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