Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"myelin-proteins"”.
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The effects of increased Plp1 gene dosage on expression and processing of myelin proteins
… the duplication of PLP1, which encodes the major myelin membrane protein of the human CNS. The #66 transgenic mice with extra copies of the wild type Plp1 gene are a valid model of PMD caused by increased gene dosage (Readhead et al., 1994). These mice develop dysmyelinating or demyelinating …
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The control of Schwann cell myelination during development and after nerve injury
… of neurons. Schwann cell differentiation and myelination is mediated by a core network of transcription factors and signalling pathways, which have been divided into two groups; positive and negative regulators. Sox10, NFATc4, Oct6, Krox20 and the ERK 1/2 signalling pathway have been …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… receptor molecule aimed at binding inhibitory myelin proteins did not appear to promote axonal regeneration, but resulted in increased infiltration of macrophages and endothelial cells. The increased vascularization observed within the scaffolds represents a modified environment that might be …
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Development of Novel Small-Molecule Therapeutics for Multiple Sclerosis
… overactive enzymes convert peptidyl arginine on myelin structural proteins to neutral citrulline variants. Hypercitrullination disrupts key ionic interactions between myelin proteins and lipid bilayers that are necessary to maintain compaction within the multi-layered myelin sheath. Thus, myelin …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… damage and loss of white matter and myelin. Furthermore, the severity of white matter damage correlates with the length of ART duration. However, almost no studies have been performed to determine how the myelin sheath or the oligodendrocytes that synthesize the sheath are damaged. …
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
"Loss of oligodendrocytes (OLs) and ensuing demyelination significantly hamper functional recovery following traumatic spinal cord injury (SCI). Although proliferating glial progenitor cells (GPCs) are present in the lesioned spinal cord, spontaneous remyelination is extremely limited. The failure …
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The Role of Nogo-A During Development of the Chick Central Nervous System
… of axon regeneration that is expressed by myelin forming oligodendrocytes of the adult central nervous system (CNS). However, neuronal expression of Nogo-A during development suggests an additional role. Little is known about the putative functions of Nogo-A during embryonic development. To …
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Charakterisierung der subzellulären Lokalisation von Myelinproteinen in der Shiverer-Maus.
Wie demyelinisierende Erkrankungen bei Mensch und Tier zeigen, erfüllt Myelin als Isolierscheide der Nervenfasern lebenswichtige Funktionen. Es handelt sich um eine Membran sehr spezifischer Zusammensetzung, deren Komponenten in komplexer Wechselwirkung mit einander stehen. Die vorliegende Arbeit …