Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"myelin regeneration"”.
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Investigating the role of cellular communication network factor 3 (CCN3) in central nervous system myelination and remyelination
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterised by immune-mediated destruction of myelin-producing oligodendrocytes. While there is a plethora of disease-modifying therapies to reduce relapses, there are currently no available treatments to boost …
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Rejuvenation of CNS Progenitors via Partial Reprogramming
… oligodendrocytes. OPCs play a critical role in myelin regeneration (remyelination), but, like all stem cells, their regenerative capacity declines with age. OPCs progressively fail to differentiate into mature oligodendrocytes following a demyelinating insult with age, and this failure plays a …
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Endogenous Neurosteroid Hormone Production and Early Oligodendricyte Development
… disorder classified by rampant demyelination, exemplifies the neuroendocrine crosstalk facilitated by CNS-resident steroids. Local steroid production from cholesterol, which also happens to be the primary lipid component of myelin sheaths, is critical to myelin repair. Progesterone …
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Cytoarchitectural Defects Secondary To Experimentally Induced Oligodendrocyte Death In The Adult And Developing Central Nervous System
… between a number of specialized cell types. Myelination is a quintessential example of such cellular communication in which highly specialized oligodendroglia extend compacted spirals of cell membrane around individual axons of multiple neurons. Functionally similar to the insulation that …
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Microglia regulate myelin growth and integrity in the central nervous system white matter
Disruption of myelin structure occurs with ageing and neurodegenerative disease, and involves myelin which is outfolding, unravelling, less compact, and thicker. This is associated with nerve dysfunction and cognitive decline; however, the mechanisms underpinning appropriate myelin structure, i.e. …