Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"myelin oligodendrocyte glycoprotein"”.
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… antibodies enter the CNS and mediate demyelination, a process that in turn amplifies the local inflammatory response (Figure 3.1.14 A). It should however be noted that lethal clinical relapses may also occur in the absence of a pathogenic antibody response if an inflammatory lesion …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
… of vaccination with a DNA construct encoding the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in multiple sclerosis, to induce tolerance and protect against experimental autoimmune encephalomyelitis (EAE) was assessed. Unexpectedly, mice vaccinated with MOG-DNA …
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Immunologische Kreuzreaktivität zwischen dem Myelin-Oligodendrozyten-Glykoprotein (MOG) und Butyrophilin (BTN) bei Multipler Sklerose
… factors that disrupt self-tolerance to myelin autoantigens but their identity and mode of action are unknown. This study reports that the epitope specificity of autoantibodies to the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in MS, is heterogeneous and …
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The Role of Therapy-Induced CD8+ T Cells in a Mouse Model of Multiple Sclerosis
… (EAE) is an induced, autoimmune, demyelinating disease model for human multiple sclerosis (MS). Glatiramer acetate (GA) is an approved immunomodulatory therapy for MS that was discovered through studies in EAE. It is thought that the main mode of action of GA is the induction of a …
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Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis
… sequencing of the mouse TCRβ repertoire during myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmuneencephalomyelitis (EAE) identified a public TCRβ chain, TCRβ1, which was highly shared among individual mice and preferentially deployed during EAE. Retrogenic expression of …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
… Chronic EAE was induced by immunization with the myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide. MOG-reactive inflammatory CD4+ T cells infiltrate the CNS and, in concert with other mononuclear cells, cause inflammation and progressive paralysis. The focus of the first study was to …
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Intestinal delivery of heterologous peptides with lactobacilli
… by destruction of several brain antigens in myelin. In order to increase the efficiency of oral tolerance induction, lactobacilli were developed as a tool to deliver heterologous protein into the gastrointestinal tract. Lactobacillus spp. are a potential delivery vehicle for oral antigens …
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Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… by an inflammatory cellular infiltration and demyelination of neuronal axons. It is believed that myelin sheath-targeting CD4 T-cells are important mediators of this disease. While it is known that CD8 T-cells are present, oligoclonally expanded and are the predominant T-cell population in the …
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An audit of the epidemiological, clinical features and outcomes of patients with Neuromyelitis Optica Spectrum Disorder (NMOSD) attending a South African Tertiary referral Hospital
… it from other forms of inflammatory CNS demyelination. This biomarker has led to recognising a broader clinical spectrum of NMOSD. Another recently discovered antibody, the anti-myelin-oligodendrocyte-glycoprotein-antibody, further broadens the spectrum of pathophysiological mechanisms and …
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Antigen-specific depletion of autoreactive B lymphocytes in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease of the central nervous system triggered by the body’s own immune system reacting against self-antigens. Autoreactive B and T lymphocytes as well as activated macrophages and the bodies complement system contribute to, and …
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Σχεδιασμός, σύνθεση και αξιολόγηση αναλόγων των ανοσοκυρίαρχων επιτόπων των πρωτεϊνών της μυελίνης που εμπλέκονται στη σκλήρυνση κατά πλάκας
Το αντικείμενο της παρούσας διατριβής ήταν η ανάπτυξη νέων ενώσεων, αναλόγων των ανοσοκυρίαρχων επιτόπων των πρωτεϊνών της μυελίνης, που εμπλέκονται στη Σκλήρυνση Κατά πλάκας (ΣΚΠ). Συγκεκριμένα, μελετήθηκαν δύο διαφορετικές στρατηγικές, που πιθανώς θα μπορούσαν να αποτελέσουν βάση για την ανάπτυξη …