Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"myelin integrity"”.
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Microglia regulate myelin growth and integrity in the central nervous system white matter
Disruption of myelin structure occurs with ageing and neurodegenerative disease, and involves myelin which is outfolding, unravelling, less compact, and thicker. This is associated with nerve dysfunction and cognitive decline; however, the mechanisms underpinning appropriate myelin structure, i.e. …
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Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
… perfusion, glial responses, and structural integrity. This study is based on the hypothesis that stroke involves disturbances of the neurogliovascular unit in remote, anatomically connected brain regions, and that these disturbances are associated with degenerative changes affecting both …
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Mitochondrial metabolism and CNS myelination
… changes. These changes precede the onset of myelination, a process in which oligodendrocyte precursor cells (OPCs) differentiate and engage with axons to invest them with complex multilamellar sheaths. Myelin sheaths enable rapid saltatory signal propagation, synchronised signal conduction, …
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DTI-ALPS REFLECTS WHITE MATTER DIFFUSION ANISOTROPY AND MICROSTRUCTURAL HETEROGENEITY RATHER THAN GLYMPHATIC FLOW: INSIGHTS FROM MULTI-MODAL MRI
… deviation (r -0.50) —consistent with altered myelin integrity and increased microstructural heterogeneity. Exploratory factor analysis demonstrated that DTI-ALPS did not form a separate latent component but clustered with MA and ODI, indicating shared variance related to axonal geometry rather …
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Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation
… over astrocytic processes in this TLE model. Myelin integrity was examined and results suggested that in the TLE model myelinated fibres were damaged in comparison to controls. Synaptic morphology was studied and results suggested that asymmetric (excitatory) synapses occurred more frequently …
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MR Susceptibility Mapping: Improved Quantification and Applications in Developmental Brain Imaging
… of the human brain are primarily composed of myelinated axons, which connect different brain regions, transmit neural signals, and form efficient communication pathways that shape the neural systems responsible for higher-order functioning. The fatty myelin sheath protects and insulates the …