Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 245 for “"myelin"”.
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Neural Circuitry Deficits Associated With Dysfunctional Myelin
… lack Claudin 11 (Cldn11) tight junctions in CNS myelin sheaths. In myelin sheaths, Cldn11 forms tight junctions located along the outer and inner edges of the membrane spiral, preventing ions and small molecules from entering the intramyelinic space. The function of Cldn11 tight junctions is to …
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Investigating the role of microglia in myelin development
We investigate the role of microglia in myelin development. Myelination is an essential process in early development that consists of the ensheathment of axons by myelin, which ensures rapid conduction of action potentials. Although myelination is predominantly driven by oligodendrocytes, the other …
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Microglia and Myelin: Improved Tools and Molecular Interactions
Myelination of axons evolved in vertebrates to promote signal transduction and the development of a compact and energy-efficient nervous system. Myelin development and homeostasis are critical for normal function and impairment of myelin is associated with sensory, motor, and cognitive dysfunction. …
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Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… from our laboratory demonstrated differential myelin-associated gene expression (MAGE) in medial prefrontal cortex (PFC) as one potential mechanism influencing acute ethanol behaviors between C57BL/6J (B6) and DBA/2J (D2) mice. Our laboratory and others have also shown MAGE is reduced in PFC of …
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The Role of Neuronal Activity in Adult Myelin Plasticity
… wrap membranes around axons to produce myelin. Their functional roles include rapid neurotransmission, synchronization, and functional maintenance. In the adult brain, 5% or more of the total cellular population consists of oligodendrocyte precursor cells, stem cells that proliferate and …
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Model-based myelin water fraction mapping: analyses and improvement
In this thesis, the problem of model-based myelin water fraction (MWF) mapping is addressed. We first focus on three of the most widely used signal models for T2*-myelin water imaging (MWI), i.e., the NNLS-multi-exponential model, the magnitude-3-exponential model, and the complex-3-exponential …
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Specific and nonspecific mechanisms in the autoimmune breakdown of myelin
Contains fulltext : mmubn000001_065207203.pdf (Publisher’s version ) (Open Access)
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Carbon-13 magic angle spinning NMR studies of myelin membranes
… a variety of model phospholipids, sphingolipids, myelin and white matter samples, resolving and assigning over 60 resonances in the spectra of human myelin samples. Spectra of fresh bovine white matter, and subsequent myelin and lipid extract preparations, revealed essentially no changes due to …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
… of vaccination with a DNA construct encoding the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in multiple sclerosis, to induce tolerance and protect against experimental autoimmune encephalomyelitis (EAE) was assessed. Unexpectedly, mice vaccinated with MOG-DNA …
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The Regulation and Mechanism of Myelin Synthesis Involving Endogenous Steroid Hormones
… were characterized and examined throughout the myelination process. The mRNA for the long form PDGF A-chain was found to be induced during myelin synthesis and was localized to the DRG neurons. Using an antibody generated against the exon 6 peptide, observations suggest that the splice variant …
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Developmental myelination and myelin plasticity during spatial working memory task acquisition
Myelin is essential for brain functioning, as it enables fast signal propagation and synchronisation of neuronal impulses. Myelin sheaths are created by oligodendrocytes, which stem from oligodendrocyte precursor cells. During development neurons become myelinated, and this process can be modulated …
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Development of a Top-Down Proteomics Platform for Characterizing Myelin Basic Protein Proteoforms
Pages x-xv are misnumbered as pages xi-xvi.
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Subcellular labelling of myelin protein (PLP and DM20) in the central nervous system
… the sub-cellular localisation of the two myelin protein isoforms encoded by the Plp1 gene in mice and thus provide insight into the functions for the two isoforms. The gene is expressed primarily by oligodendroglia of the central nervous system (CNS), with some expression (primarily of …
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Microglia regulate myelin growth and integrity in the central nervous system white matter
Disruption of myelin structure occurs with ageing and neurodegenerative disease, and involves myelin which is outfolding, unravelling, less compact, and thicker. This is associated with nerve dysfunction and cognitive decline; however, the mechanisms underpinning appropriate myelin structure, i.e. …
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Third Harmonic Generation: A Method for Visualizing Myelin in the Murine Cerebral Cortex
… Generation (THG) for the label-free imaging of myelinated axons in the murine cerebral cortex. Myelin plays an important role in the processes of learning and disease. However, much of the myelin biology research thus far has focused on white matter tracts where myelin is more visible. Much is …
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Characterization of an Alternatively Spliced Platelet-Derived Growth Factor Variant During Myelin Synthesis
… cell cocultures and shown to regulate myelin synthesis. mRNA transcripts of the long-form PDGF-A chain variant (LF-PDGF-A) were detected by RT-PCR in cocultures. Its expression level increased during active myelin synthesis in contrast to those of the short form variant (SF-PDGF-A). …
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
… and animal models present cataracts and hypomyelinating disorders linked to neurological impairment. Yet, it remains unclear how gene expression of cholesterol biosynthesis is regulated in lens and brain. Therefore, studying cholesterol biosynthesis in both tissues could potentially provide …
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
… and animal models present cataracts and hypomyelinating disorders linked to neurological impairment. Yet, it remains unclear how gene expression of cholesterol biosynthesis is regulated in lens and brain. Therefore, studying cholesterol biosynthesis in both tissues could potentially provide …
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