Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"mycophenolic acid"”.
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Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients
The purpose was to identify the pharmacokinetic and pharmacodynamic profiles, to establish the PK-PD relationship of MPA and to quantify average population pharmacokinetic and pharmacodynamic parameters and evaluate the influence covariates on the PK-PD variability.Stable renal transplant patients …
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Proteomic investigation of the molecular targets of mycophenolic acid in human cells
Mycophenolic acid (MPA) is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key regulator of purine biosynthesis. MPA is frequently used as an immunosuppressant drug to prevent acute graft rejection for kidney, liver and lung transplantation. The use of MPA is associated with GI …
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Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… anti-flaviviral drugs (e.g., bortezomib and mycophenolic acid) and others that had no previously known antiviral activity (e.g., daptomycin) were identified as inhibitors of ZIKV infection. Several drugs reduced ZIKV infection across multiple cell types.</p><p>We propose that the EMC may be …
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In vitro studies of the effects of funfal-derived immunosuppressive agents on MCF7 breast cancer cells and Molt4 Leukaemia cells
… and results were compared to the effects of Mycophenolic acid (MPA) and Rapamycin (Rapa) in the search 6for new approaches that may explain controversy of these agents. CsA is a cystostatic drug that has been reported to arrest the cells in the early Gi phase of the cell cycle thus protecting …
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Pharmaceuticals in the Environment: Assessing Potential Risks to Fish
… (beta-blocker), quetiapine (antipsychotic), mycophenolic acid (MPA; immunosuppressant), clozapine (antipsychotic) and olaparib (antineoplastic). Inter-relationships between API exposure and drug clearance processes in trout hepatocytes were also investigated by quantifying selected gene …
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Comparison of the two lumpy skin disease virus vaccines, Neethling and Herbivac, and construction of a recombinant Herbivac-Rift Valley fever virus vaccine
… with the transfer vector, in the presence of mycophenolic-acid selection medium.
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Der Einfluss von Mycophenolat-Mofetil (MMF) auf die renale Fibrogenese: Bedeutung für neue therapeutische Ansätze
Im Rahmen dieser Arbeit wurde das antifibrotische Potential von Mycophenolat-Mofetil (MMF) bzw. seines aktiven Metaboliten Mycophenolsäure (MPA) untersucht. Hierfür wurden einerseits ein in-vitro-Modell für renale Fibroblasten (COS-7-Zellen) und andererseits COL4A3-defiziente Mäuse als Tiermodell …