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Showing 1 to 3 of 3 for “"mycolyl arabinogalactan"”.
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Molecular and biochemical characterisation of novel glycosyltransferases in Mycobacterium tuberculosis
The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, such as Mycobacterium tuberculosis and is the target of several antitubercular drugs. Arabinofuranosyltransferase enzymes, such as EmbA, EmbB, and AftA, play pivotal roles in the biosynthesis of …
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Channel-forming proteins in the cell wall of amino acid-producing Corynebacteria
… walls of most actinomycetes contain besides an arabinogalactan-peptidoglycan complex large amounts of mycolic acids. This three-layer envelope is called MAP (mycolyl-arabinogalactan-peptidoglycan) complex and it represents a second permeability barrier beside the cytoplasmic membrane similar to …
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Discovery of Natural Product-based Antimycobacterial Agents Effective against Non-replicating Bacilli
<p>New antimycobacterial molecules that kill non-replicating Mycobacterium tuberculosis (Mtb) were identified by screening libraries of synthetic natural products. De novo screening of a 400-membered library of aurachin RE analogs resulted in discovery of UT-317 ((R)-20). UT-317 is a selective …