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Showing 1 to 1 of 1 for “"mycobacterium, tuberculosis, natural product, ClpC, drug discovery, ATPase"”.
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Mycobacterium tuberculosis ClpC1: A potential target for tuberculosis drug discovery
A whole cell-based screen of natural product for new anti-TB agents at Novartis identified a compound X displaying potent activity against Mycobacterium tuberculosis (MIC50=0.05-0.1N<M). This compound is active against multidrug resistant clinical isolates, implying a new target. A preliminary …