Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mycobacterial cell envelope"”.
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Chemical Probes and Strategies to Study Mycobacterial Cell Envelope Assembly
The cell envelope of Mycobacterium tuberculosis (Mtb) is central to its pathogenicity, immune evasion, and intrinsic drug resistance. While the importance of its glycan components is well recognized, their structural intricacies have hindered efforts to directly perturb and investigate their …
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Probing the Mycobacterial Cell Envelope: CRISPR interference-mediated investigation of two essential genes in the galactan biosynthetic pathway
… the need for the identification of essential cellular pathways in mycobacteria that can be targeted for novel drug development. A key feature of Mtb that confers intrinsic tolerance to many antibiotics is its complex cell envelope. The mycobacterial cell envelope is a dynamic compartment which …
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Barriers to tuberculosis drug discovery: the mycobacterial cell wall
The mycobacterial cell wall is a highly complex macromolecular structure that provides intrinsic resistance to several anti-tuberculosis drugs, making it critical in the success of Mycobacterium tuberculosis infection. Multiple layers encapsulate the cell membrane, including arabinogalactan chains …
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Functional Characterisation of the Mycobacterial Virulence Protein Erp
… must continually resist host defences. A major mycobacterial survival mechanism lies in the unusual and complex cell envelope. The mycobacterial cell envelope provides a robust permeability barrier that helps the bacteria tolerate the variety of host insults it encounters. Many mycobacterial …
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The clinical relevance of structural modifications in the cell envelope glycans of Mycobacterium abscessus
… M. abscessus pulmonary infection was ubiA, a cell envelope biosynthetic gene. UbiA catalyzes the biosynthetic pathway of the arabinose donor required for the biosynthesis of two important molecules in the cell envelope, arabinogalactan (AG) and lipoarabinomannan (LAM). The mycobacterial cell …
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A Chemical-Genetic Map of Drug Resistance in Mycobacterium Tuberculosis
… These data provided a nuanced picture of how the mycobacterial cell envelope serves as a selective barrier to antibiotic penetration. We found that antibiotic activity can be potentiated via selective inhibition of cell envelope synthetic enzymes as well as regulatory proteins. These data also led …