Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"mutators"”.
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Mathematical Modeling and Disease Related Applications: A New Method of Estimating Bacterial Mutation Rates, Dynamics of Killer Yeast in a Chemostat, and Other Problems
… explores bacterial mutation rate, mutants, mutators, and how competition acts as a driving force of adaptation.</p> <p>In chapter 1, the system used in reference for mutation is the devolopment of <i>Pseudomonas aeruginosa</i> antibacterial resistance in the Cystic Fibrosis patients. Current …
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Mathematical Modeling and Disease Related Applications: A New Method of Estimating Bacterial Mutation Rates, Dynamics of Killer Yeast in a Chemostat, and Other Problems
… explores bacterial mutation rate, mutants, mutators, and how competition acts as a driving force of adaptation.</p> <p>In chapter 1, the system used in reference for mutation is the devolopment of <i>Pseudomonas aeruginosa</i> antibacterial resistance in the Cystic Fibrosis patients. Current …
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Evolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung
… months in duration. A subset of these contained mutators, operationally defined as producing RifR mutants at a frequency one order of magnitude or greater than the population median (2.5x10-8). Strains were phenotyped with respect to mucoid status, antibiotic resistances, and frequency of RifR …
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Evolution of Pseudomonas aeruginosa in the Cystic Fibrosis Lung
… months in duration. A subset of these contained mutators, operationally defined as producing RifR mutants at a frequency one order of magnitude or greater than the population median (2.5x10-8). Strains were phenotyped with respect to mucoid status, antibiotic resistances, and frequency of RifR …
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Evolutionary Instability Of Genomic Mutation Rate In Rapidly Adapting Asexual Mutator Escherichia Coli Populations
Alleles conferring higher mutation rates (mutators) can fix in asexual populations through a process called ‘mutator hitchhiking’. Theory predicts that repeated mutator hitchhiking can occur in an adapting asexual mutator population. I tested this prediction in two settings: a mutL- population …
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An experimental investigation into the mechanisms of bacterial evolution
… I will examine the fixation probability of mutators competing with wild-type in novel environment. I also will utilize simulations to study the impact of three parameters on the fixation probability. </p>
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Hypermutation and adaptation of experimentally evolved marine Vibrio bacteria
… pathogens, from very different environments. Mutators are known to arise spontaneously in wild and clinical bacteria, but the extent of their adaptive contribution is unknown. We have preliminary evidence that this mechanism of evolution could be relevant in the environment, where horizontal …
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Bioluminescence-Based High Precision Bacterial Growth Rate Measurements and Their Potential Application in Quantifying Deleterious Effects of High Mutation Rates
… results have been explained by positing that mutators offer a short-term benefit in the form of increased probability of generation of beneficial mutations. Yet, given that a majority of non-neutral mutations are deleterious, there is a long-term cost associated with high mutation rates. This …
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Robustness and Reliability of Federated Learning
… Our results show that most faults (mutators) have a negligible effect on the final trained model when leveraging existing aggregators, but this is not the case with all attacks. However, choosing the most robust FL aggregator depends on the attack type and datasets. Therefore, we …