Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mutational robustness"”.
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Neutral Networks of Real-World Programs and their Application to Automated Software Evolution
… software projects. These properties of 'mutational robustness' and the corresponding 'neutral networks' have been studied extensively in biology and are believed to be related to the capacity for unsupervised evolution and adaptation. As in biological systems, mutational robustness and …
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Spectral analysis of neutral evolution
… of evolution can be analysed by examining the mutational network formed by sequences of equal fitness, that is, the neutral network. It has been demonstrated that, in large populations under a high mutation rate, the population distribution over the neutral network and average mutational …
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Thermodynamics of neutral sets and sequence length changes in the genotype-phenotype map of RNA secondary structure
… GP map model. In the third chapter, we focus on mutational robustness in a more general GP map, which includes sequence length changes and is based on the RNAshapes concept. We find that robustness to insertions and deletions is correlated with robustness to substitutions. This holds both for …
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Directed evolution of amino acid dehydrogenases for biocatalysis of chiral amines
… single cell assay. Second, I investigated how mutational robustness may correlate with protein stability and lead to successful hits after mutagenesis and screening. To examine this issue, I initially investigated various approaches (including ancestral resurrection and computational design) to …
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How codon choice determines evolvability and evolutionary robustness in short linear motifs
… specific codons have higher motif evolutionary robustness, i.e. they can tolerate more mutations without affecting function. I went on to investigate if these predicted properties have played a role in motif evolution in influenza. I found that conserved motifs in influenza use the codons …
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Exploring protein fitness landscapes with new high-throughput technologies
… the starting point results in increased mutational robustness, broadening the range of accepted mutations. However, increased initial stability does not necessarily correlate to higher functional improvement, hinting at a nuanced view of evolvability. A sensitive high-throughput assay is …