Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"mutated residue"”.
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Investigating the Interactions Between the Thiolate Ligand and Mutants of a Conserved Tryptophan in the Proximal Heme Pocket of the Oxygenase Domains of Endothelial and Staphyloccus Aureus Nitric Oxide Synthases
… enzyme. The mutation of a conserved tryptophan residue, which hydrogen bonds to the coordinating thiolate ligand and therefore influences its electronegativity, to either phenylalanine or tyrosine has had various effects including heme loss and dimer disruption in the inducible isoforms, while …
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Structure-function of Dengue 2 virus envelope protein domain III with neutralizing antibodies
… was done in order to map functionally important residues for binding of a panel of 13 ED3-specific MAbs. Seven of these MAbs were DENV-2 type-specific and recognized a single antigenic site on ED3 that centered on two functionally critical residues (K305 and P384) for binding. The other six MAbs …
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Inference of degree of significance of single amino acids from the literature
… whether or not all of the completely conserved residues have been noted and considered for functional inference. Out of several thousand papers, we find four residues that are completely conserved but unmentioned in any article; F85, E112, P156, S159. F85 and E112 are in fact completely …
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Identification of hepatitis C virus core protein residues critical for the interaction with the cellular DEAD-Box Helicase DDX3 and their functional relevance
… and release. A library of HCV core mutants (residues 1-59 only) was produced by error-prone PCR and subsequently expressed in bacteria and analysed for their ability to bind bacterially expressed DDX3 using a rapid, high throughput ELISA screen. Six HCV core residues, conserved throughout all …