Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"mushroom body"”.
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Dopaminergic Modulation Shapes Sensorimotor Processing in the Drosophila Mushroom Body
… and learned associations. In Drosophila, the mushroom body is a prominent neural structure essential for olfactory learning. Dopaminergic neurons convey salient information about reward and punishment to the mushroom body in order to adjust synaptic connectivity between Kenyon cells, the …
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Mushroom body expansion and the cognitive ecology of Heliconius butterflies
… of an insect brain structure called the mushroom bodies (MBs), which are 3-4 times larger than in other Lepidoptera, including closely related Heliconiini genera. MBs are known to play a role in learning and memory, particularly in olfactory contexts, however the relative cognitive …
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The Octopaminergic Modulatory Circuitry of the Drosophila Larval Mushroom Body Calyx
… and genetically amenable Drosophila larval Mushroom Body (MB) calyx, a higher order processing area involved in learned odour discrimination, as a model to map octopamine (OA) neuromodulatory circuitry. I first identified olfactory projection neurons (PNs), a GABAergic feedback neuron and …
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Octopaminergic Regulation of Olfactory Discrimination in the Drosophila Larval Mushroom Body Calyx
The mushroom bodies of insect brains are essential for memory formation. The sensory input region of the mushroom bodies, the calyx, processes information received from stereotypic olfactory input channels, the Projection Neurons (PNs). Mushroom body neurons, Kenyon cells (KCs), integrate these …
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Characterization of the pleiotropic effects of the Drosophila gene mushroom body miniature B
The mushroom body miniature B ( mbmB) mutation has documented defects in adult mushroom body anatomy, olfactory memory and female fertility. In this thesis I report that mbmB mutants also have reduced viability and growth rate. I further demonstrate, using the mushroom body cell marker dachshund, …
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Representations of Reward and Movement in Drosophila Dopaminergic Neurons
… and how they influence concurrent behavior. The mushroom body, a prominent neuropil in the brain of the fruit fly Drosophila melanogaster, is richly innervated by dopaminergic neurons that play an essential role in the formation of olfactory associations. While dopaminergic neurons respond to …
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Dopamine and the Temporal Dependence of Learning and Memory
… understood. Using the simple architecture of the mushroom body, an olfactory associative learning center in Drosophila, I examined how the relative timing of olfactory inputs and dopaminergic reinforcement signals is encoded at the molecular, synaptic, and circuit level to give rise to learned …
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A Scent of Direction: Exploring Adaptive Olfactory Navigation in Drosophila
… dopaminergic reinforcement pathways within the mushroom body, a brain center that mediates associative olfactory learning. Anatomically, the mushroom body is well-positioned to modulate edge-tracking behavior due to its many connections with other key brain regions involved in spatial navigation …
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Postembryonic Development and Adult Plasticity of the Mushroom Bodies in the Honey Bee Brain
The mushroom bodies are distinctive, paired neuropils in the insect brain. Convergence of numerous sensory modalities in the mushroom bodies indicates that they may be a center for sensory integration. Ablation and lesioning experiments have also established a role for this brain region in …
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IMPACT OF PESTICIDES ON THE NEURAL STRUCTURE OF THE HONEY BEE, APIS MELLIFERA
… and memory in the honey bee, Apis mellifera. The mushroom bodies, insect brain regions required for learning and memory, receive GABAergic inputs that may be sensitive to fipronil. The synaptic organization of the mushroom bodies was investigated in adult worker honey bees exposed to fipronil …
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Localizing engrams of olfactory memories in Drosophila
… an engram of aversive olfactory memory to the mushroom bodies of Drosophila (Zars et al., 2000). In this thesis, I followed up on this finding in two ways. Inspired by Zars et al. (2000), I first focused on the whether it would also be possible to localize memory extinction.While memory …
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Life on the Edge: Insights into the Neural and Behavioral Algorithms of Plume Tracking
… we reveal that edge-tracking relies on the mushroom body and central complex, two highly interconnected brain centers implicated in olfactory learning and spatial navigation. In particular, the ongoing activity of dopaminergic neurons of the mushroom body previously implicated in associative …
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Neural Regions Affecting Female Aggression and Receptivity in Drosophila melanogaster
… Silencing a candidate region called the mushroom body (MB) was found to decrease female receptivity. Additionally, silencing a specific subset of the MB, the alpha/beta lobes, was also found to decrease receptivity. SIFamide neurons are known to effect receptivity, though manipulation of …
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ANALYSIS OF TWO NOVEL COMPLEXES THAT REGULATE NEUROBLAST SELF-RENEWAL AND ASYMMETRIC DIVISION IN DROSOPHILA MELANOGASTER
… 2 (Ana2) and regulates the localization of Mushroom body defect (Mud). Ana2, Ctp and Mud form a protein complex to regulate spindle orientation in neuroblasts.
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Drosophila CPEB, Orb2, a Putative Biochemical Engram of Long-term Memory
… Orb2. I find that aggregated Orb2 in subset of mushroom body neurons can serve as a “molecular signature” of memory and predict memory strength. My data indicate that self-sustaining aggregates of Orb2 may serve as a physical substrate of memory and provide a molecular basis for the perduring …
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The organisation of a third-order olfactory brain region in the vinegar fly
… neurons, particularly those outside the mushroom body, the centre for associative learning, are poorly understood. Here I present data and analyses for such third-order neurons as well as the tools I have helped to make my analyses possible. Using full synaptic reconstructions for neurons …
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Chronic contact exposure to realistic soil concentrations of a neonicotinoid insecticide represents a potentially important and unexplored route of exposure for ground nesting bees
… effects of this type of exposure on adult bee mushroom body growth. The results presented here suggest that neonicotinoid contamination of soils represents a potentially important route of exposure for ground nesting bees. A number of sublethal effects were detected in response to treatment …
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Circuit Mechanisms of Context-dependent Memory-based Action Selection
… such as the Striatum (vertebrates) and the Mushroom Body (MB) (invertebrates) are thought to carry out classical conditioning (Eichler et al., 2017; Heisenberg, 2003; Suri & Schultz, 1999). This process allows animals to associate conditioned stimuli (CSs) with rewards or punishments …
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Transcriptional response to spatial learning and foraging in honey bees: molecular bases for adult neuroplasticity
… growth and remodeling of processes in the mushroom bodies, a paired region of the insect brain involved in sensory integration, learning and memory. Honey bees (Apis mellifera) learn to navigate in the environment surrounding the hive by performing orientation flights for several days …
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Functional characterization of the role of Imp, a Drosophila mRNA binding protein, during oogenesis
… factor 1 (E2f1), lingerer (lig), snail (sna) and mushroom body expressed (mub). E2f1 encodes a transcriptional factor that is involved in regulating the G1 to S phase transition during mitosis. Mutation of E2f1 results in altered grk mRNA and protein distribution within oocyte, revealing a role …
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