Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"muscle wasting"”.
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Sex Differences in Cancer Cachexia and a Novel Mitochondrial Target for Cancer-Induced Muscle Wasting
<p>Cancer cachexia (CC) is a devastating wasting syndrome characterized by marked weight loss including skeletal muscle atrophy that affects approximately 80% of cancer patients. Current therapeutic treatments including pharmacological and nutritional intervention are insufficient to prevent or …
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Selective Muscle Degeneration in a Drosophila Model of Cachexia; A Role for the Transcriptional Regulator cabut
… metabolic syndrome characterized by progressive muscle wasting. Cachectic muscle wasting presents as a comorbidity with pathological illnesses like cancer, chronic inflammation, and type 2 diabetes. The development of cachexia complicates treatment of these diseases and worsens clinical outcomes. …
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An investigation of NADPH oxidase in normal and diseased skeletal muscle
… degenerative conditions, such as skeletal muscle wasting and therefore this study sought to determine a role for the superoxide generating NADPH oxidase and antioxidant enzyme systems in conditions of skeletal muscle wasting. The results of these studies indicated changes in the gene …
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Amino Acid Sensing in Muscle: Role of the lysosome and the effect of protein supplementation on improving amino acid sensitivity in aging muscle
… a well-studied stimulus for increasing skeletal muscle protein synthesis. Only recently has the mechanism for this phenomenon been elucidated at the cellular level. To this point, most of the mechanistic research into this process has been conducted in human embryonic kidney cells. Therefore, it …
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Global analysis of mRNA decay rates and RNA-binding specificity reveals novel roles for CUGBP1 and PARN deadenylase in muscle cells
… by myotonia, cardiac conduction defects, muscle wasting, and insulin resistance. In patient muscle cells expression and function of the RNA-binding proteins CUGBP1 and MBNL1 are disrupted, resulting in altered mRNA metabolism at the levels of splicing and translation. Intriguingly, despite …
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Duchenne muscular dystrophy : mutation profiling in view of the emerging gene-based therapies
… Dystrophy (DMD) is a lethal, X-linked, recessive muscle-wasting disorder affecting 1 in 3 500 live male births worldwide, for which only palliative care is available to date. Large exonic deletions or duplications are found in approximately 70% of DMD patients, for which diagnostic testing is …
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Effect of Severe Burn Injury on Body Composition and Muscle Metabolism in Pediatric Patients
Muscle wasting in burn injury is associated with increased morbidity and mortality. Burn-induced muscle cachexia is partly attributed to lack of physical activity imposed by standard of care. Moreover, evidence supports that muscle tissue is catabolized to provide amino acids necessary for wound …
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Proteomic Characterisation of the mdx-4cv mouse model of Duchenne Muscular Dystrophy
… as a stabilising support network during normal muscle excitation-contraction-relaxation cycles. In Duchenne muscular dystrophy, the loss of dystrophin and its associated protein complex leads to membrane instability and micro-rupturing, the influx of excessive levels of calcium ions, the …
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The nature of cachexia in patients with heart failure and stable coronary artery disease
… loss of a percentage of body weight over time. Muscle wasting has been assumed to be the major contributor to this weight loss, and cytokine activation is postulated to be central to the pathogenesis. We hypothesised that elevated circulating cytokines in cachectic heart failure patients would …
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Partial GSK3 knockdown improves muscle performance in mdx mice: investigating the cellular mechanisms
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by an X-linked mutation to the dystrophin gene that primarily affects boys. The absence of functional dystrophin protein leads to muscle wasting and weakness that progressively worsens over time with affected boys typically …
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Assessment of nutritional status in patients with acquired immunodeficiency syndrome (AIDS)
… (AIDS). Estimates of body fat and skeletal muscle were measured using triceps-skinfold, mid-arm circumference, mid-arm muscle area, and creatinine height index. Body weight was compared to standards for height and sex. Serum albumin and transferrin levels were measured to estimate visceral …
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MOTONEURON MAINTENANCE DEFECTS AND NON-CELL AUTONOMOUS CONTRIBUTIONS BY SCHWANN CELLS IN ZEBRAFISH MUTANT AND MORPHANT MODELS FOR SPINAL MUSCULAR ATROPHY
… i.e. motoneuron loss, locomotor deficiencies, muscle wasting and early lethality. Studies in SMA animal models suggested a non-cell autonomous contribution of Schwann cell defects to MN degeneration. Supporting this, I found that restoration of Smn in Schwann cell precursors (SCPs) of smn …
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Effects of acute and chronic exercise on forearm blood flow in patients with chronic heart failure
… blood flow, deconditioning and skeletal muscle atrophy. Initially, a study of the biological and technical reliability of the techniques used in the latter chapters was conducted. Reliability of these techniques has not previously been documented in a population of CHF patients. The …
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Development of a SNP Assay for the Differentiation of Allelic Variations in the mdx Dystrophic Mouse Model
… muscular dystrophy (DMD), a severe and fatal muscle wasting disease. To evaluate possible treatments and to carry out genetic studies, it is essential to distinguish between mice that carry the mutant dystrophic or wt allele(s). The current Amplification-Resistant Mutation System (ARMS) assay …
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Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex in skeletal muscle
… disorder characterized by severe and progressive muscle degeneration, which is caused by mutations in the gene encoding the dystrophin protein. Dystrophin is required for assembly of the dystrophin-glycoprotein complex (DGC) and provides a mechanically strong link between the cytoskeleton and the …
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The role of stress-derived vesicles in the bystander effect and cancer related cachexia
… in the induction of cancer-cachexia, a muscle wasting disease. This disease is common in patients with cancer and is often linked to poor prognosis. In this project the ability of EVs released from heat shocked cells to induce bystander effects has been assessed. EVs released from cancer …
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Transcriptional Regulation of Neurogenic Atrophy-Induced Gene Expression by Muscle Ring Finger-1 and Myogenic Regulatory Factors
Skeletal muscle wasting is a consequence of numerous physiological conditions, including denervation, corticosteroid treatment, immobilization, and aging. The E3 ubiquitin ligases, MuRF1 and MAFbx, are induced under nearly all atrophy conditions and are believed to play a key role in protein …
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Skeletal Muscle Protein Turnover During Cancer Cachexia In the Apc<sup>min/+</sup> Mouse
<p>Cancer cachexia is a complex wasting condition associated with the loss of skeletal muscle and fat mass. Muscle wasting exhibits an imbalance in the rate at which proteins are synthesized and degraded, referred to as protein turnover. Our laboratory has shown the ApcMin/+ mouse, a model of …
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Characterizing PDK4 and PKC-Theta in Pancreatic Cancer and Cachexia
Cachexia is an involuntary wasting syndrome that cannot be reversed by nutritional support. It affects most patients with pancreatic ductal adenocarcinoma (PDAC) and is believed to cause 20% of cancer-associated deaths. Cachectic patients exhibit both metabolic abnormalities and systemic …
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