Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"muscle regeneration"”.
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Muscle cell-derived cytokines in muscle regeneration
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Cellular and molecular regulation of skeletal muscle regeneration
<p>Skeletal muscle regeneration provides a powerful model to study the cellular and molecular mechanism governing stem cell function since the whole process is mediated by a population of muscle-resident stem cells called satellite cells. The overall aim of this dissertation is to explore the roles …
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The Role of Oxidative Stress in Skeletal Muscle Regeneration
… tissue involves the coordinated activities of muscle precursor cells (MPCs) in response to local and systemic signals. Following tissue injury, the microenvironment, which is characterized by excessive production of reactive oxygen species (ROS), is attenuated. Here we studied the efficacy of …
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The Role of Ring1 and Rnf2 in Skeletal Muscle Regeneration
The skeletal muscle environment is highly complex, with inputs from multiple cell types and environmental challenges in homeostatic and regenerative conditions. Satellite cells, a population of quiescent adult stem cells, maintain the regenerative potential of muscle well into adulthood, but the …
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THE EFFECT OF SDF1α ON SKELETAL MUSCLE REGENERATION AFTER COMPARTMENT SYNDROME INJURY
Introduction: Skeletal muscle dysfunction, whether due to injury, disease or age, can be debilitating to normal life. There are few effective treatments for severe skeletal muscle injuries. SDF1α is a chemokine which promotes migration of stem cells through binding to the CXCR4 receptor and has …
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Development of a fibrin-based muscle construct for soft palate muscle regeneration
Contains fulltext : 244739.pdf (Publisher’s version ) (Open Access)
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T cell mediated satellite cell function: implications for age-associated changes in skeletal muscle regeneration
Sarcopenia is an age-associated loss of skeletal muscle mass and strength. Recent evidence suggests that an age-associated loss of muscle precursor cell (MPC) functionality contributes to sarcopenia. Current research also suggests that T cells of the immune system may influence skeletal muscle …
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Muscle regeneration in the soft palate of the rat. Novel perspectives for cleft palate repair
Contains fulltext : 160825.pdf (Publisher’s version ) (Open Access)
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Functional Genomics Characterization of Six4 During Skeletal Myogenesis
Adult skeletal muscles can regenerate after injury due to the presence of satellite cells, a quiescent population of myogenic progenitor cells characterized by expressing the transcription factor Pax7. Once activated, satellite cells repair the muscle damage and replenish the stem cell niche due to …
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The role of growth factors in the regeneration of skeletal muscle
… the insulin-like growth factor (IGF) axis during regeneration, to determine whether these factors were temporally regulated during regeneration, whether the absence or presence of growth hormone (GH) affected their levels, and lastly, whether the administration of exogenous IGF-II enhanced muscle …
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The role of myostatin during postnatal myogenesis and sarcopenia
… negative regulator of embryonic and postnatal muscle growth. In order to further elucidate the role of myostatin during postnatal growth, several lines of investigation were undertaken in mice. Analysis of myostatin downstream target genes identified several known and unknown genes. From these, …
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Non-canonical functions of leucyl-tRNA synthetase: Mechanism of cell growth and skeletal myogenesis
… growth, myogenic differentiation, and skeletal muscle regeneration. Amino acid availability activates signaling by mTORC1. The class III PI-3-kinase Vps34 mediates amino acid signaling to mTORC1 by regulating lysosomal translocation and activation of the phospholipase PLD1. In collaboration with …
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The Role of Vitamin D in Skeletal Muscle Function and Regeneration
Skeletal muscle is a direct target for the group of seco-steroids collectively termed Vitamin D. Skeletal muscle expresses both CYP27A1 and CYP27B1 encoding for the hydroxylases required to convert Vitamin D to 25[OH]D and subsequently the bioactive 1α-25-dihydroxyvitamin D3 (1α-25[OH]2D3) (Girgis …
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Potential adaptive signaling pathways in the diaphragm of mdx mice treated with micro-dystrophin combined with voluntary running
… were also similar. The diaphragm is an important muscle for endurance exercise. Remarkably, diaphragm power in mdxRGT was depressed compared to mdxGT, suggesting a negative impact of running on GT. To explore mechanisms to explain this decrease, transcriptome profiles for each of the study groups …
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Development and Characterization of Tunable, Bioinspired Electrospun Constructs for Skeletal Muscle Engineering
Volumetric muscle loss, as a result of high intensity sports injury, trauma or tumor ablation, affects more than 250,000 civilians each year in the U.S. alone and accounts for more than 50% of all DoD disabilities. These injuries often leave patients with permanent structural and functional …
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Regulation of skeletal myogenesis by the mTOR signaling network
Skeletal muscle is composed of post-mitotic multinucleated myofibers. During embryonic skeletal myogenesis, cells in somites commit to myogenic lineage and differentiate into myoblasts, which then fuse to form multinucleated myofibers. Post-natal growth, repair, and maintenance of skeletal muscle …
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
… cellular identity. The mechanisms regulating muscle stem and progenitor cell identity have ramifications for understanding all aspects of myogenesis. The epigenetic mechanisms regulating muscle stem cells are therefore important aspects for understanding the regulation of muscle regeneration …
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Impacts of dietary obesity on muscle stem cell behaviors
… in human and animal health. In mouse skeletal muscle, obesity has been shown to impair muscle regeneration after injury, however, the mechanism underlying these changes in satellite cell (SC) biology have yet to be explored. To test the negative impacts of obesity on SC behaviors, we fed …
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The Immediate Early Response of Proliferating Myoblasts to One Bout of Electrical Stimulation
The maintenance of muscle mass is important across the lifespan. The activation of satellite cells, followed by their proliferation and subsequent differentiation is important in this maintenance. Cell cycle arrest must precede differentiation, and preservation of the molecular networks involved …
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