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Showing 1 to 20 of 20 for “"muscle injury"”.
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The acute effects of two different training models on markers of inflammatory activation and skeletal muscle injury in patients with chronic heart failure
… systems and the catabolism of skeletal muscle. Although exercise training is important in the management of HF, acute bouts of exercise may lead to increases in proinflammatory cytokines. It is believed that the skeletal muscle abnormalities associated with HF may increase the risk of …
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Design of a rodent dynamometer
… of velocity, acceleration, and position on muscle injury. However, the effect of constant force on muscle injury in animals has not yet been studied.;A computer-controlled dynamometer was designed which could perform isometric, isovelocity, and isotonic testing on both male and female rats. …
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Effects of low and high intensity exercises on serum mean values of myoglobin and heart-type fatty acid-binding protein in athletes
In current study we reviewed some muscle injury markers published in recent decades, firstly. Creatine kinase (CK) and myoglobin (Mb) are routinely used to evaluate the injuries in laboratory tests. High CK activity is detectable in muscle, heart and brain. CK-MM is the main isoenzyme in muscle. It …
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Analysis of the biochemical mechanisms of heterotopic ossification following musculoskeletal trauma
… a stimulating event, such as musculoskeletal injury, releases a combination of circulating factors that promote heterotopic ossification, likely through the activation of the BMP-2 receptor is a primary pathway leading to heterotopic ossification. However, further research must confirm the …
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N-ethylmaleimide sensitive factor (NSF) is a regulator of plasma membrane rupture and necrotic cell death
… Nsf knockout mice and induced skeletal muscle injury via cardiotoxin injection. Loss of NSF protected against sarcolemmal rupture and myocyte death. Complementarily, cardiomyocyte-specific deletion of Nsf protected against ischemia-reperfusion injury. The SNARE complex regulator, NSF, is …
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Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
… oculis homeobox family has been tied to skeletal muscle formation. Work completed thus far has allowed our research team to identify the precise mechanism by which Six1 regulates the expression of MyoD, a key myogenic gene, in muscle stem cells. Furthermore, loss-of-function of this protein, …
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The Effects of Chronic Prophylactic Naproxen Sodium on Skeletal Muscle Adaptation to Resistance Exercise in Recreationally-Trained College-Aged Males
Resistance exercise causes exercise-induced muscle injury (EIMI), triggering an acute local inflammatory response associated with delayed-onset muscle soreness (DOMS). DOMS is characterized by a predictable discomfort and decreased level of muscle performance and is believed to be the product of …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
Satellite cells are normally a quiescent skeletal muscle stem cell pool that upon activation rapidly proliferate and differentiate to repair damaged muscle fibers. The paired box transcription factor 7 (Pax7) is the canonical biomarker for quiescent, activated, and proliferating satellite cells and …
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Exercise and free radical induced damage to human skeletal muscle
… free radical induced damage to human skeletal muscle, with a review of related literature. It has been proposed muscle adapts to eccentric exercise by increasing its resting length. The first study investigated the effects of manipulating knee extensor (KE) length during eccentric actions, on …
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The impact of spinal stabilization exercises on pain, disability, and physical functional after lumbar spinal fusion
… have been developed in an attempt to reduce muscle injury, some damage is unavoidable. Research on postoperative rehabilitation has not kept pace with the increased utilization of LSF in the United States over the past three decades, and there is a lack of high-quality evidence to answer …
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Analytical validation and evaluation of the effects of intramuscular injections on acute phase proteins in horses
… HAP were observed. These findings indicate that muscle injury caused by PPG injections may result in increased CK and AST activity and increased plasma concentration of a subset of APP including FIB and SAA.
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The Effects of Exercise-Induced Muscle Damage With or Without Omega-3 Supplementation on Inflammation, Muscle Function and Recovery in Healthy Physically Active Younger and Older Adults
… exercise is associated with reductions in muscle force output, muscle pain, avoidance of repeated loading and a transient inflammatory response. Whilst exercise-induced muscle damage (EIMD) is well defined in the literature in healthy younger populations, research into older individuals is …
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Longissimus muscle fatigue and injury response due to electrical stimulation with varied work/rest ratios
<p>LONGISSIMUS MUSCLE FATIGUE AND INJURY RESPONSE DUE TO ELECTRICAL STIMULATION WITH VARIED WORK/REST RATIOS</p> <p>BY</p> <p>PETER WAWROW</p> <p>May 2011</p> <p>Advisor: John Cavanaugh, MD</p> <p>Major: Biomedical Engineering</p> <p>Degree: Doctor of Philosophy</p> <p>The estimated yearly cost of …
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In Vitro Equine Flexor Tendonitis: New Model Development and Therapeutic Investigation
… serum (ACS) in humans for treatment of muscle injury has been shown to speed tissue regeneration. ACS produced from human blood has been shown to contain significantly increased levels of III growth factors that may improve tendon fibril formation and strength. We propose to investigate …
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Investigating the use of omega three fish oils as protective agents against cytokine-induced skeletal muscle damage
IntroductionMuscle injury and disease impacts on the lives of adults and children, contributing tosevere morbidity and increased mortality e.g. Muscular dystrophy affects over 70,000people UK wide (Muscular Dystrophy UK). Treatment of muscle disorders contributeto unemployment rates and cost the …
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Muscle-derived cytokines: novel regulators of skeletal myogenesis
Mature skeletal muscle has a uniquely robust capacity for regeneration. This ability is due in large part to the resident population of muscle stem cells in the tissue, known as satellite cells. These adult stem cells reside in a quiescent state near the basal lamina of skeletal myofibers, but are …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… Guillain-Barre syndrome and myositis-like muscle injury [2, 4–8], suggesting detrimental effects of SARS-CoV-2 on both the central and peripheral nervous system (CNS, PNS). Multiple studies have shown neuroinflammation in patients with COVID-19, which may underlie these neurological and …
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The effect of whey protein-polyphenol on the recovery of muscle function and strength following eccentric exercise- the myogenic and neural contributions to eccentric exercise.
… intramuscular forces generated in lengthened muscle, especially in individuals unaccustomed to such exercise. Despite the typical characteristics of exercise-induced muscle damage (EIMD), the complete mechanistic underpinning of EIMD remains to be fully determined, particularly with respect to …
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An investigation into the novel effects of melatonin treatment on differentiated C2C12 myotubes in the absence and presence of pathology
… oxidative stress, mitochondrial dysfunction and injury-related damage to skeletal muscle. However, despite its promising therapeutic potential, much remains unknown with regard to its impact on healthy or pathologically challenged skeletal muscle. Principle Findings for paper 1: MEL at the higher …
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Muscle damage and the repeated bout effect in male bodybuilders following unaccustomed resistance exercise
This study investigated muscle damage of bodybuilders who performed an unaccustomed intense resistive exercise bout. Ten male bodybuilders (age: 23 ± 2 y, height: 177.6 ± 6.3 cm, body mass: 85.7 ± 8.1 kg) with a minimum of 4-years resistance training experience performed 17 exercises targeting the …