Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"muscle differentiation"”.
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The role of Calcineurin in skeletal muscle differentiation
… that Calcineurin levels are higher in fast muscle fibers compared to slow-twitch in resting skeletal muscles. Activation of the Calcineurin in 4 skeletal muscle myocytes selectively up-regulates slowfiber- specific gene promoters through a mechanism involving the transcription factor NFATcI. …
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Genomic characterization of Six1 function during skeletal muscle differentiation
… Six1 to Six6). Six1 is important for skeletal muscle development: Six1-/- mouse neonates die at birth because of severe muscle hypoplasia. However, the molecular targets of Six1 are poorly characterized systematically. The Myogenic Regulatory Factors (MRFs) are critical transcription factors in …
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Exogenous leucyl-tRNA synthetase inhibits mouse skeletal muscle differentiation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Regulation of Skeletal Muscle Differentiation by a Rapamycin -Sensitive Signaling Pathway
To gain further insight into myogenic regulation of mTOR, the structure-function relationship of mTOR was examined by a series of truncation and deletion mutants. Strikingly, the results indicate that the C-terminal 1187 amino acids are sufficient for mTOR's myogenic function and the N-terminal …
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The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation
… proliferation, the role of NR4A1 in skeletal muscle differentiation was also explored. We found that <em>NR4A1 </em>increased during the differentiation of human LHCN myoblasts, and that knockdown of <em>NR4A1 </em>impairs differentiation and reduces expression of myogenic markers in LHCN as …
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Genome-wide identification of enhancers, transcription factors, and mechanisms that control skeletal muscle differentiation in cattle
Skeletal muscle development and growth involve significant changes in gene expression. The overall objective of this dissertation project was to identify transcription factors, enhancers, and mechanisms that control gene expression during skeletal muscle development and growth on a genome-wide …
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Keratose Hydrogels Promote Vascular Smooth Muscle Differentiation from c-kit+ Human Cardiac Stem Cells: Underlying Mechanism and Therapeutic Potential
… and uncontrollable in vivo differentiation after transplantation has limited the efficacy of stem cell therapy. Tissue engineering solutions offer potential tools to overcome current limitations of stem cell therapy. Materials derived from natural sources such as keratin from …
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Ruolo della PLCγ1 e della PKCε nel differenziamento miogenico
… transduction pathway for cell proliferation and differentiation. Studies on signalling through the insulin/IGF-1 receptors in muscle differentiation have revealed that PLCγ1 is involved during this process and that both mRNA and protein levels were increased during myogenesis. Based on increasing …
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Manipulating Stiffness of Biomechanical Systems to Train Muscle
… scale soft robots powered by engineered muscle actuators, was developed to provide a binary change in stiffness. Two variations of the design were created, one using elastic 50A resin and the other PDMS. The elastic 50A resin design was fabricated successfully. The design uses a manually …
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The myocyte enhancer factor-2 (MEF2) family mediates complex gene regulation in skeletal and cardiac myocytes
Regulation of striated muscle differentiation and development are complex processes coordinated by an array of transcription factors. MEF2 is a crucial transcription factor required for muscle differentiation, but the roles of the individual MEF2 family members, MEF2A-D, have not been extensively …
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High-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcoma
… as sarcomas that show exclusive evidence of muscle differentiation, but differ in their pathogenesis and prognosis. ARMS typically occurs in adolescents, presents as disease of the extremities, has a higher risk of metastasis or treatment-resistance, and in 75% of cases, is characterized by …
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Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
… upstream activator MEK5 are abundant in skeletal muscle a function of the cascade during muscle differentiation was examined. ERK5 becomes activated upon induction of differentiation in mouse myoblasts. The selective activation of the pathway results in promoter activation of …
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Role of JAK3 in Myogenic Differentiation
Skeletal muscle differentiation is regulated by transcription factors, including members of the myogenic regulatory factors (MRFs) family and many signaling pathways. The JAK1 and JAK2 pathways are known to each have different effects on myoblast proliferation and differentiation; however, the role …
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MOLECULAR DEFECTS OF MEF2 FAMILY PROTEINS AND NAC PROTEINS THAT BLOCK MYOGENESIS AND PROMOTE TUMORIGENESIS IN RHABDOMYOSARCOMA
… RMS cells have many features of skeletal muscle cells, yet do not differentiate. Thus, our studies have focused on the molecular defects present in these cells that block myogenesis. We have found MEF2D is absent in RMS cell lines representing both major subtypes of RMS and primary cells …
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A High-Throughput Approach to Uncover Novel Roles of APOBEC2, a Functional Orphan of the AID/APOBEC Family
… diverse organisms and cellular processes such as muscle biology (in Mus musculus), regeneration (in Danio rerio), and development (in Xenopus laevis). APOBEC2 has also been implicated in cancer. However the enzymatic activity, substrate or physiological target(s) of APOBEC2 are unknown. For this …
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Modeling Time-Varying Networks with Applications to Neural Flow and Genetic Regulation
… or changes in genetic regulation during cell differentiation. Approaches are needed that explicitly model networks as they change in time and that characterize the nature of those changes.</p><p>In this work, we develop a new class of graphical models in which the conditional dependence …
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Characterization of aortic carboxypeptidase-like protein mutations that cause Ehlers-Danlos syndrome
… in collagen polymerization, vascular smooth muscle differentiation, and myofibroblast differentiation. There have been multiple ACLP mutations that have been implicated in EDS. Previous studies have shown an ACLP mutation Asn490_Met495delins, a mutation with intron inclusion in the protein, …
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Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… E18.5. Cell apoptosis, proliferation, and smooth muscle differentiation were unchanged in <em>Yap<sup>+/-</sup>; Taz<sup>-/-</sup> </em>CKO mutants. Comparably, <em>Yap<sup>+/-</sup>; Taz<sup>+/-</sup> </em>double heterozygous hearts exhibited external morphology similar to that of controls, but …
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Characterizing the Mechanisms Regulating Enhancer Commissioning by MyoD in Muscle Cells
… refers to the cellular process required for muscle formation and repair of damaged muscle tissue. During this process, the activation of muscle gene expression is tightly regulated to ensure efficient transitions between cell fates. This activation is promoted by large groups of neighbouring …
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IN-VITRO VASCULARIZED TISSUE EQUIVALENTS FROM HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL AND VASCULAR SMOOTH MUSCLE CELLS
… endothelial cells (ECs) and vascular smooth muscle cells (vSMCs). Human embryonic stem cells (hESCs) are virtually an unlimited source of differentiated cells including ECs and vSMCs. However, current differentiation strategies need improvisation in terms of efficiency, reproducibility, and …
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