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Showing 1 to 20 of 34 for “"muscle biopsy"”.
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The effects of prolonged exercise on Na+, K+ - ATPase and SR Ca2+ regulation in humans
… changes, but little is known about effects on muscle Na+, K+ATPase activity and sarcoplasmic reticulum (SR) Ca2+ regulation. We therefore investigated whether these processes were impaired during cycling exercise at 74.3±1.2% v02 peak (mean±SEM) continued until fatigue, in eight healthy …
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The effect of oral creatine supplementation on one hour cycling performance and metabolism
… cycle ergometer. Five days later subjects had a muscle biopsy and an indwelling cannula was inserted into a forearm vein before performing a maximal one-hour cycle (T1) during which blood samples were taken at regular intervals. Following the cycle, the subjects each received either Cr or placebo …
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Skeletal Muscle Adaption to 5 days of High-Fat Feeding in Humans
Skeletal muscle is highly involved in macronutrient metabolism. To maintain proper energy metabolism and physiology, skeletal muscle must adapt to nutrient supply. Thus, diet macronutrient composition is an important modulator of skeletal muscle metabolism. Evidence from rodent and human models …
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Comparison of short-term sprint interval versus traditional endurance training on metabolic adaptations in sedentary overweight/obese men
… baseline and 72 h after the final training bout. Muscle biopsy samples were taken from the vastus lateralis at the same time points, and analysed for proteins associated with glucose uptake and mitochondrial function. No significant changes in BMI, body composition,V̇ O2peak, fasting plasma …
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Das T-Zell-Rezeptor-Repertoire bei der Polymyositis
… that destroy HLA class I-expressing skeletal muscle fibres. Recently we demonstrated that the autoaggressive T lymphocytes in PM muscle are clonally expanded. We employed a new PCR-based method to identify and characterize clonally expanded T cell populations. The method (CDR3-Spectratyping) …
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Skin cells as a tool in genetic diagnosis of Duchenne muscular dystrophy
… obtaining an invasive, often distressing, muscle biopsy. This dissertation investigated the utility of human autologous epidermal melanocyte and dermal fibroblast cell cultures for use as a tool for genetic confirmation of D/BMD from a much less invasive shave skin biopsy. Methodologies …
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Dynamic proteome profiling of human muscle responses to high-intensity interval training
Skeletal muscle is the most abundant tissue in the body and it plays a central role in whole-body metabolism. Physical inactivity and obesity are associated with poor metabolic health due to insulin resistance of peripheral tissues, in particular skeletal muscle. Conversely, a physically active …
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Non-Invasive and Invasive Assessment of Carbohydrate Intakes and Muscle Glycogen Utilisation in Rugby League and AFL
The importance of muscle glycogen availability for both endurance and high-intensity intermittent exercise performance has been recognised for several decades. The measurement of muscle glycogen in human skeletal muscle has traditionally been performed through the invasive muscle biopsy technique. …
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Skeletal muscle morphology and function in former elite distance runners : a 20 year follow-up
… and functional characteristics of skeletal muscle. Sixty men (current age = 49.2 ± 2.4 yr.) were first studied between 1966-1974 when they were all highly trained. Based on their training regimens in the interim between testing, subjects were described as highly trained (HI), fitness trained …
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The Effect of Protein Blend Supplementation and Resistance Exercise on Skeletal Muscle Growth and Adaptation
… efficacy of a new protein supplement to improve muscle growth and strength when ingested following exercise. The hypothesis is that novel supplementation of mixed dietary proteins (protein “blend”) with different amino acid release profiles will prolong amino acid levels in the blood leading to …
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The impact of carbohydrate ingestion on the regulation of fat oxidation following exercise
… after, and A h after exercise, subjects had a muscle biopsy taken from the vastus lateralis. Results: Subjects exercised at a similar %VO2peak during both the CHO (71.5 2 I -8% v02peak) and the PLA (72.5 2 1.8%VO2peak) trials. Energy expended during and following exercise was similar between …
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Effects of four weeks of daily soy or dairy milk ingestion on the exercise-induced proteolytic responses in plasma and skeletal muscle in a post-menopausal female population.
Sarcopenia is defined as a loss of muscle mass and muscle strength associated with aging. Changes in muscle function can occur as early as the fourth decade of life. Evidence indicates that the calpain and ubiquitin proteolytic degradation pathways account for the majority of myofibrillar protein …
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HIV-Polymyositis progressing to inclusion body myositis: clues to earlier diagnosis
… as HIV-associated PM (HIV-PM) clinically and on muscle biopsy, change into a treatment-resistant HIV-IBM clinical phenotype. These cases are referred to as HIV-PM/IBM overlap syndrome. In recent years at Groote Schuur Hospital (GSH), we have also encountered patients with HIV-PM/IBM. Aims The …
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The Effects of an Acute Bout of Neuromuscular Electrical Stimulation on Anabolic Signaling of the mTORC1 Pathway in Individuals with Chronic Stroke
… causes limited ability to produce voluntary muscle contraction and movement on one side of the body leading to further muscle wasting and weakness. Neuromuscular electrical stimulation (NMES) is often used to facilitate involuntary muscle contraction; however, the effect of NMES on muscle …
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The fiber type specific response of single muscle fiber contractile performance to endurance and resistance exercise training in healthy, sedentary adults
It is well documented that human skeletal muscle is highly responsive to exercise training. However, the impact of endurance and resistance exercise training on single muscle fiber (SMF) physiology has not been well studied in healthy, sedentary individuals. The current study documented the fiber …
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The Effect of a Probiotic Supplement on Insulin Sensitivity and Skeletal Muscle Substrate Oxidation during High Fat Feeding
… VSL#3 on body weightand composition, skeletal muscle substrate oxidation, and insulin sensitivity and during 4 weeks of high-fat, hypercaloric feeding. We hypothesized that the probiotic would attenuate the body weight and fat gain and adverse changes in insulin sensitivity and substrate …
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Non-lethal methods for assessing the health and status of fish species of conservation concern.
… studies from non-lethally collected fin, muscle biopsy, and pectoral fin rays, and compares these benchmark values to those from lethally collected fillets and otoliths. Specifically, the endpoints measured were stable isotopes of nitrogen (δ15 N) and carbon (δ13 C), mercury (Hg), and age …
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The Role and Appraisal of Online Videos in Postgraduate Health Education
… tools. A video in the processing of a skeletal muscle biopsy was created, and the barriers and facilitators to this process were identified. A rubric was developed to assess the quality of online videos used to teach procedural skills, with good content validity. EFA, CFA and reliability testing …
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The Role of High Saturated Fatty Acid Diets on Skeletal Muscle Metabolism and Inflammation
… if the metabolic adaptive response in skeletal muscle to a single, high fat meal was altered by 5 days of high saturated fat feeding. Twelve college-age, non-obese males were studied and skeletal muscle samples were obtained prior to and concluding the consumption of a high SFA diet. In a subset …
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Plasma Extracellular Vessicles, Exercise Resistnace and Cancer
… of EVs released from platelets, adipocytes, muscle cells, and hepatocytes, with the goal of identifying tissue-specific EV markers. Further, we applied the SEC-MS approach to evaluate the effects of endurance and resistance exercise on EV proteomic cargo in human plasma. A prerequisite to …
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