Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"muscimol"”.
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Determination of Dissociation Constants for GABAA Receptor Antagonists using Spontaneously Active Neuronal Networks in vitro
… of GABAA antagonists and titrated with muscimol, a GABAA receptor agonist. Muscimol decreased spike activity in a concentration dependent manner with full efficacy (100% spike inhibition) and a 50% inhibitory concentration (IC50) of 0.14 ± 0.05 µM (mean ± SD, n=6). At 10, 20, 40 and 80 …
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Systemic administration of putrescine induces GABA-like behaviors in rats
… compared to effects produced by a GABA agonist, muscimol. Male adult rats were given either saline, putrescine, or muscimol, and later treated with saline or apomorphine. Locomotor and specific activities were time sampled for 45 minutes. Results indicated that putrescine and muscimol had similar …
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A prefrontal source of visual target enhancement in the macaque area V4
… area V4 by recording in V4 with and without muscimol inactivation in the VPA. We report here that neuronal activation in the VPA is necessary for firing rate increases related to target selection in V4. KEYWORDS: feature attention, visual search, muscimol, neurophysiology
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Ovarian Hormone Modulation of Learning Strategy Preferences: A Role for Hippocampal Disinhibition
… intrahippocampal infusions of the GABAA agonist muscimol caused proestrous rats to shift from a place to a response strategy preference (Chapter 3). To evaluate the independent role of estrogen in the muscimol-induced response strategy preference at proestrus, strategy preferences in …
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Regulation of Luteinizing Hormone and Catecholamine Release
… the GABAg agonist, baclofen, the GABA^ agonist, muscimol, or either the GABA^ antagonist, bicuculline, or the putative GABAg antagonist, 5-aminovalerate. Additional experiments tested the effects of the GABA drugs on LH release in ovariectomized, hormonally untreated rats and in response to …
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The synthesis and biochemical and pharmacological evaluation of gamma-aminobutyric acid antagonists
… using (3H)-GABA, the potent GABA agonist (3H)-muscimol also with GABA antagonists using (3H)-bicuculline methobromide and (3H)-dihydropicrotoxinin. Utilising these methods a number of agonists and antagonists have been examined to evaluate their ability to displace the stereospecific binding. …
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Νευροφαρμακολογία και λειτουργική ανατομία των βασικών γαγγλίων του εγκεφάλου: Πειραματική μελέτη σε επίμυες
… intracaudate injections of the GABA agonist muscimol or the GABA antagonist picrotoxin in d-amp treated rate also revealed differences between dorsal and ventral striatum, pointing out a complex interaction between DA receptor subtypes and GABAergic striatal efferents. It is widely accepted …
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Modelling the Neuropsychopharmacology of Obsessive-Compulsive Disorder in the Common Marmoset (Callithrix jacchus)
… reversibly inactivated using the GABAA agonist muscimol. Results indicated dose-related impairments specifically in reversal learning within the putamen, with sparing of discrimination retention. By contrast, similar reversible inactivation of the caudate nucleus produced marked deficits in …
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A Novel Naturalistic Paradigm to Study Aerial Predator-Induced Fear
… amygdala (BLA) was temporarily inactivated with muscimol. With the BLA inactivated no fear responses were seen and the rat efficiently retrieved the pellet during the owl encounter. This novel paradigm provides a new way to investigate innate defense mechanisms rats use to avoid predation.
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Gabapentin Discriminative Stimulus Effects
… mg/kg. The GABA<sub>A </sub>receptor agonist muscimol and NMDA noncompetitive receptor antagonist MK-801 partially substituted for the gabapentin discriminative stimulus. NMDA receptor agonism attenuated the effects of gabapentin. Ethanol partially substituted for gabapentin and potentiated …
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Effects of Whisker-Trimming on GABAA Receptors in S1 Cortex
… marks. In deprived whisker barrel columns, [3H]muscimol binding to GABAA receptors decreased by 12.8% ± 1.2 (P < 0.001) in layers 2/3 and 11.4% ± 1.2 (P<0.001) in layer 4. Altered levels of GABAA α1 subunit (Fritschy et al., 1994) were indicated by reduced optical density of immunostaining, both …
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The Role of GABA in Reproductive Neuroendocrine Systems
… LHRH release from the median eminence, while muscimol could change 5-HIAA release.</p>
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Investigating brain-wide neural mechanisms using fMRI and novel tools
… The tool is a conjugate of the inhibitory drug muscimol to a paramagnetic contrast agent. I show that this reagent allows neurophysiological consequences of local inhibition to be characterized in spatial and temporal dimensions, creating a facile basis for assessing the contributions of …
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How does the primate ventral visual stream causally support core object recognition?
… millimeter-scale regions of IT via injection of muscimol while monkeys performed several interleaved binary object discrimination tasks. We found that inactivating different millimeter-scale regions of primate IT resulted in different patterns of object recognition deficits, each predicted by the …
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An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding
… VTA with direct injections of the GABA agonist, muscimol. This resulted in mice reducing their licking (relative to baseline) of sucralose, but not QHCl or water (i.e., an arrangement of non-caloric stimuli with palatable, aversive, and neutral valence). Muscimol also reduced licking of sucrose …
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The synthesis and pharmacology of gamma-aminobutyric acid receptor mimetics
… using 3H-GABA itself, a potent GABA agonist, 3H-muscimol, and the GABA antagonist, 3H-bicuculline methiodide. Recently, it has been suggested that 1,2,3,6 Tetrahydropyridine-4-carboxylic acid (Isoguvacine) is a potent GABA receptor agonist. It has also been reported to act as a mixed …
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Orbitofrontal Cortex and Social Processing in Rodent Models
… local intracranial injection of GABAA agonist, muscimol, impaired two different measures of SR in which two conspecifics, or members of the same species, one novel and one familiar, were presented and required discrimination. Novelty seeking, decision-making, memory, and gregariousness were …
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Role of rat medial prefrontal cortex in time interval estimation
… as either long or short. Bilateral infusions of muscimol (GABAA receptor agonist) into the mPFC significantly impaired animal’s performance in this task, even when the animals were required to discriminate between only the longest and shortest time intervals. These results show the requirement of …
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The role of ventrolateral prefrontal cortex in performance of spatial self-ordered response sequences in the marmoset
… that local inactivation of vlPFC using muscimol/baclofen infusions impairs sequencing. This effect was shown to be selective to performance of sequences that varied spatially from trial to trial; thus, no effects of vlPFC inactivation were observed for performance of a fixed response …
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Investigation Of Whether Sedentary And Physically Active Conditions Lead To Altered Gabaergic Signaling In The Rvlm
… RVLM was inhibited with 90 nl of 2mM Muscimol and the GABA injections were repeated. There were no significant differences between SED or EX conditions for BP, HR and sSNA responses to GABA before contralateral blockade of RVLM. However, after contralateral blockade of the RVLM, the …
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